PPARs, Cardiovascular Metabolism, and Function: Near- or Far-from-Equilibrium Pathways
Peroxisome proliferator-activated receptors (PPAR α, β/δ and γ) play a key role in metabolic regulatory processes and gene regulation of cellular metabolism, particularly in the cardiovascular system. Moreover, PPARs have various extra metabolic roles, in circadian rhythms, inflammation and oxidativ...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2010-01-01
|
| Series: | PPAR Research |
| Online Access: | http://dx.doi.org/10.1155/2010/783273 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832565531587117056 |
|---|---|
| author | Yves Lecarpentier Victor Claes Jean-Louis Hébert |
| author_facet | Yves Lecarpentier Victor Claes Jean-Louis Hébert |
| author_sort | Yves Lecarpentier |
| collection | DOAJ |
| description | Peroxisome proliferator-activated receptors (PPAR α, β/δ and γ) play a key role in metabolic regulatory processes and gene regulation of cellular metabolism, particularly in the cardiovascular system. Moreover, PPARs have various extra metabolic roles, in circadian rhythms, inflammation and oxidative stress. In this review, we focus mainly on the effects of PPARs on some thermodynamic processes, which can behave either near equilibrium, or far-from-equilibrium. New functions of PPARs are reported in the arrhythmogenic right ventricular cardiomyopathy, a human genetic heart disease. It is now possible to link the genetic desmosomal abnormalitiy to the presence of fat in the right ventricle, partly due to an overexpression of PPARγ. Moreover, PPARs are directly or indirectly involved in cellular oscillatory processes such as the Wnt-b-catenin pathway, circadian rhythms of arterial blood pressure and cardiac frequency and glycolysis metabolic pathway. Dysfunction of clock genes and PPARγ may lead to hyperphagia, obesity, metabolic syndrome, myocardial infarction and sudden cardiac death, In pathological conditions, regulatory processes of the cardiovascular system may bifurcate towards new states, such as those encountered in hypertension, type 2 diabetes, and heart failure. Numerous of these oscillatory mechanisms, organized in time and space, behave far from equilibrium and are “dissipative structures”. |
| format | Article |
| id | doaj-art-c6766407e35e40af9d87d0a8e249b3e8 |
| institution | Kabale University |
| issn | 1687-4757 1687-4765 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | PPAR Research |
| spelling | doaj-art-c6766407e35e40af9d87d0a8e249b3e82025-02-03T01:07:30ZengWileyPPAR Research1687-47571687-47652010-01-01201010.1155/2010/783273783273PPARs, Cardiovascular Metabolism, and Function: Near- or Far-from-Equilibrium PathwaysYves Lecarpentier0Victor Claes1Jean-Louis Hébert2Service de Physiologie, Hôpital de Bicêtre, Assistance Publique-Hôpitaux de Paris, 94275 Le Kremlin-Bicêtre, FranceDepartment of Pharmaceutical Sciences, University of Antwerpen, 2670, Wilrijk, BelgiumService de Physiologie, Hôpital de Bicêtre, Assistance Publique-Hôpitaux de Paris, 94275 Le Kremlin-Bicêtre, FrancePeroxisome proliferator-activated receptors (PPAR α, β/δ and γ) play a key role in metabolic regulatory processes and gene regulation of cellular metabolism, particularly in the cardiovascular system. Moreover, PPARs have various extra metabolic roles, in circadian rhythms, inflammation and oxidative stress. In this review, we focus mainly on the effects of PPARs on some thermodynamic processes, which can behave either near equilibrium, or far-from-equilibrium. New functions of PPARs are reported in the arrhythmogenic right ventricular cardiomyopathy, a human genetic heart disease. It is now possible to link the genetic desmosomal abnormalitiy to the presence of fat in the right ventricle, partly due to an overexpression of PPARγ. Moreover, PPARs are directly or indirectly involved in cellular oscillatory processes such as the Wnt-b-catenin pathway, circadian rhythms of arterial blood pressure and cardiac frequency and glycolysis metabolic pathway. Dysfunction of clock genes and PPARγ may lead to hyperphagia, obesity, metabolic syndrome, myocardial infarction and sudden cardiac death, In pathological conditions, regulatory processes of the cardiovascular system may bifurcate towards new states, such as those encountered in hypertension, type 2 diabetes, and heart failure. Numerous of these oscillatory mechanisms, organized in time and space, behave far from equilibrium and are “dissipative structures”.http://dx.doi.org/10.1155/2010/783273 |
| spellingShingle | Yves Lecarpentier Victor Claes Jean-Louis Hébert PPARs, Cardiovascular Metabolism, and Function: Near- or Far-from-Equilibrium Pathways PPAR Research |
| title | PPARs, Cardiovascular Metabolism, and Function: Near- or Far-from-Equilibrium Pathways |
| title_full | PPARs, Cardiovascular Metabolism, and Function: Near- or Far-from-Equilibrium Pathways |
| title_fullStr | PPARs, Cardiovascular Metabolism, and Function: Near- or Far-from-Equilibrium Pathways |
| title_full_unstemmed | PPARs, Cardiovascular Metabolism, and Function: Near- or Far-from-Equilibrium Pathways |
| title_short | PPARs, Cardiovascular Metabolism, and Function: Near- or Far-from-Equilibrium Pathways |
| title_sort | ppars cardiovascular metabolism and function near or far from equilibrium pathways |
| url | http://dx.doi.org/10.1155/2010/783273 |
| work_keys_str_mv | AT yveslecarpentier pparscardiovascularmetabolismandfunctionnearorfarfromequilibriumpathways AT victorclaes pparscardiovascularmetabolismandfunctionnearorfarfromequilibriumpathways AT jeanlouishebert pparscardiovascularmetabolismandfunctionnearorfarfromequilibriumpathways |