Rapid Microwave-Assisted Synthesis of CuSe Nanoparticles for High-Sensitivity Serotonin Biosensing in Serum
In this study, a simple and effective approach was developed for the quantitative detection of serotonin. Hexagonal copper selenide nanostructures (CuSe) were employed to modify a disposable screen-printed carbon electrode (SPCE), and their ability to electrochemically detect serotonin in serum samp...
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MDPI AG
2025-07-01
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| Series: | Chemosensors |
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| Online Access: | https://www.mdpi.com/2227-9040/13/7/264 |
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| author | Sankar Sekar Ramalingam Manikandan Shiva Kumar Arumugasamy Saravanan Sekar Youngmin Lee Seung-Cheol Chang Sejoon Lee |
| author_facet | Sankar Sekar Ramalingam Manikandan Shiva Kumar Arumugasamy Saravanan Sekar Youngmin Lee Seung-Cheol Chang Sejoon Lee |
| author_sort | Sankar Sekar |
| collection | DOAJ |
| description | In this study, a simple and effective approach was developed for the quantitative detection of serotonin. Hexagonal copper selenide nanostructures (CuSe) were employed to modify a disposable screen-printed carbon electrode (SPCE), and their ability to electrochemically detect serotonin in serum samples was investigated. The fabricated CuSe nanostructures exhibited an interconnected, cluster-like morphology composed of irregularly shaped particles with a distinct hexagonal crystal structure. The electrochemical results revealed that the CuSe/SPCE sensor showed better electrochemical activity and good analytical sensing performance towards serotonin detection. The sensor exhibited a linear response in the concentration range of 10 to 1000 nM, with an excellent correlation coefficient (R<sup>2</sup> = 0.9998) and a low detection limit of 3 nM. Furthermore, the CuSe/SPCE showed better selectivity, impressive sensitivity (12.45 µM/µA cm<sup>−2</sup>), and good reproducibility toward serotonin detection, making it a promising electrochemical biosensor for serotonin detection in various real biological samples. |
| format | Article |
| id | doaj-art-c674e9b1bacb456ca0b6703bbd3ae582 |
| institution | Kabale University |
| issn | 2227-9040 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Chemosensors |
| spelling | doaj-art-c674e9b1bacb456ca0b6703bbd3ae5822025-08-20T03:58:25ZengMDPI AGChemosensors2227-90402025-07-0113726410.3390/chemosensors13070264Rapid Microwave-Assisted Synthesis of CuSe Nanoparticles for High-Sensitivity Serotonin Biosensing in SerumSankar Sekar0Ramalingam Manikandan1Shiva Kumar Arumugasamy2Saravanan Sekar3Youngmin Lee4Seung-Cheol Chang5Sejoon Lee6Division of System Semiconductor, Dongguk University-Seoul, Seoul 04620, Republic of KoreaDepartment of Cogno-Mechatronics Engineering, College of Nanoscience and Nanotechnology, Pusan National University, Busan 46241, Republic of KoreaDepartment of Chemical and Biochemical Engineering, Dongguk University-Seoul, Seoul 04620, Republic of KoreaDepartment of Mechanical Engineering, K. Ramakrishnan College of Technology, Trichy 621112, IndiaDivision of System Semiconductor, Dongguk University-Seoul, Seoul 04620, Republic of KoreaDepartment of Cogno-Mechatronics Engineering, College of Nanoscience and Nanotechnology, Pusan National University, Busan 46241, Republic of KoreaDivision of System Semiconductor, Dongguk University-Seoul, Seoul 04620, Republic of KoreaIn this study, a simple and effective approach was developed for the quantitative detection of serotonin. Hexagonal copper selenide nanostructures (CuSe) were employed to modify a disposable screen-printed carbon electrode (SPCE), and their ability to electrochemically detect serotonin in serum samples was investigated. The fabricated CuSe nanostructures exhibited an interconnected, cluster-like morphology composed of irregularly shaped particles with a distinct hexagonal crystal structure. The electrochemical results revealed that the CuSe/SPCE sensor showed better electrochemical activity and good analytical sensing performance towards serotonin detection. The sensor exhibited a linear response in the concentration range of 10 to 1000 nM, with an excellent correlation coefficient (R<sup>2</sup> = 0.9998) and a low detection limit of 3 nM. Furthermore, the CuSe/SPCE showed better selectivity, impressive sensitivity (12.45 µM/µA cm<sup>−2</sup>), and good reproducibility toward serotonin detection, making it a promising electrochemical biosensor for serotonin detection in various real biological samples.https://www.mdpi.com/2227-9040/13/7/264CuSe nanoparticlesserotoninbiosensorsynergistic effectserum samples |
| spellingShingle | Sankar Sekar Ramalingam Manikandan Shiva Kumar Arumugasamy Saravanan Sekar Youngmin Lee Seung-Cheol Chang Sejoon Lee Rapid Microwave-Assisted Synthesis of CuSe Nanoparticles for High-Sensitivity Serotonin Biosensing in Serum Chemosensors CuSe nanoparticles serotonin biosensor synergistic effect serum samples |
| title | Rapid Microwave-Assisted Synthesis of CuSe Nanoparticles for High-Sensitivity Serotonin Biosensing in Serum |
| title_full | Rapid Microwave-Assisted Synthesis of CuSe Nanoparticles for High-Sensitivity Serotonin Biosensing in Serum |
| title_fullStr | Rapid Microwave-Assisted Synthesis of CuSe Nanoparticles for High-Sensitivity Serotonin Biosensing in Serum |
| title_full_unstemmed | Rapid Microwave-Assisted Synthesis of CuSe Nanoparticles for High-Sensitivity Serotonin Biosensing in Serum |
| title_short | Rapid Microwave-Assisted Synthesis of CuSe Nanoparticles for High-Sensitivity Serotonin Biosensing in Serum |
| title_sort | rapid microwave assisted synthesis of cuse nanoparticles for high sensitivity serotonin biosensing in serum |
| topic | CuSe nanoparticles serotonin biosensor synergistic effect serum samples |
| url | https://www.mdpi.com/2227-9040/13/7/264 |
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