Rapid Microwave-Assisted Synthesis of CuSe Nanoparticles for High-Sensitivity Serotonin Biosensing in Serum
In this study, a simple and effective approach was developed for the quantitative detection of serotonin. Hexagonal copper selenide nanostructures (CuSe) were employed to modify a disposable screen-printed carbon electrode (SPCE), and their ability to electrochemically detect serotonin in serum samp...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-07-01
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| Series: | Chemosensors |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-9040/13/7/264 |
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| Summary: | In this study, a simple and effective approach was developed for the quantitative detection of serotonin. Hexagonal copper selenide nanostructures (CuSe) were employed to modify a disposable screen-printed carbon electrode (SPCE), and their ability to electrochemically detect serotonin in serum samples was investigated. The fabricated CuSe nanostructures exhibited an interconnected, cluster-like morphology composed of irregularly shaped particles with a distinct hexagonal crystal structure. The electrochemical results revealed that the CuSe/SPCE sensor showed better electrochemical activity and good analytical sensing performance towards serotonin detection. The sensor exhibited a linear response in the concentration range of 10 to 1000 nM, with an excellent correlation coefficient (R<sup>2</sup> = 0.9998) and a low detection limit of 3 nM. Furthermore, the CuSe/SPCE showed better selectivity, impressive sensitivity (12.45 µM/µA cm<sup>−2</sup>), and good reproducibility toward serotonin detection, making it a promising electrochemical biosensor for serotonin detection in various real biological samples. |
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| ISSN: | 2227-9040 |