Seroepidemiology of SARS-CoV-2 in a cohort of pregnant women and their infants in Uganda and Malawi.
<h4>Background</h4>Data on SARS-CoV-2 infection in pregnancy and infancy has accumulated throughout the course of the pandemic, though evidence regarding asymptomatic SARS-CoV-2 infection and adverse birth outcomes are scarce. Limited information is available from countries in sub-Sahara...
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Public Library of Science (PLoS)
2024-01-01
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| author | Lauren Hookham Liberty Cantrell Stephen Cose Bridget Freyne Luis Gadama Esther Imede Kondwani Kawaza Samantha Lissauer Phillipa Musoke Victoria Nankabirwa Musa Sekikubo Halvor Sommerfelt Merryn Voysey Kirsty Le Doare periCOVID Consortium |
| author_facet | Lauren Hookham Liberty Cantrell Stephen Cose Bridget Freyne Luis Gadama Esther Imede Kondwani Kawaza Samantha Lissauer Phillipa Musoke Victoria Nankabirwa Musa Sekikubo Halvor Sommerfelt Merryn Voysey Kirsty Le Doare periCOVID Consortium |
| author_sort | Lauren Hookham |
| collection | DOAJ |
| description | <h4>Background</h4>Data on SARS-CoV-2 infection in pregnancy and infancy has accumulated throughout the course of the pandemic, though evidence regarding asymptomatic SARS-CoV-2 infection and adverse birth outcomes are scarce. Limited information is available from countries in sub-Saharan Africa (SSA). The pregnant woman and infant COVID in Africa study (PeriCOVID Africa) is a South-South-North partnership involving hospitals and health centres in five countries: Malawi, Uganda, Mozambique, The Gambia, and Kenya. The study leveraged data from three ongoing prospective cohort studies: Preparing for Group B Streptococcal Vaccines (GBS PREPARE), SARS-CoV-2 infection and COVID-19 in women and their infants in Kampala and Mukono (COMAC) and Pregnancy Care Integrating Translational Science Everywhere (PRECISE). In this paper we describe the seroepidemiology of SARS-CoV-2 infection in pregnant women enrolled in sites in Uganda and Malawi, and the impact of SARS-CoV-2 infection on pregnancy and infant outcomes.<h4>Outcome</h4>Seroprevalence of SARS-CoV-2 antibodies in maternal blood, reported as the proportion of seropositive women by study site and wave of COVID-19 within each country.<h4>Methods</h4>The PeriCOVID study was a prospective mother-infant cohort study that recruited pregnant women at any gestation antenatally or on the day of delivery. Maternal and cord blood samples were tested for SARS-CoV-2 antibodies using Wantai and Euroimmune ELISA. In periCOVID Uganda and Malawi nose and throat swabs for SARS-Cov-2 RT-PCR were obtained.<h4>Results</h4>In total, 1379 women were enrolled, giving birth to 1387 infants. Overall, 63% of pregnant women had a SARS-CoV-2 positive serology. Over subsequent waves (delta and omicron), in the absence of vaccination, seropositivity rose from 20% to over 80%. The placental transfer GMR was 1.7, indicating active placental transfer of anti-spike IgG. There was no association between SARS-CoV-2 antibody positivity and adverse pregnancy or infancy outcomes. |
| format | Article |
| id | doaj-art-c673b8e9537d4fb88d87e21ffb020b43 |
| institution | OA Journals |
| issn | 1932-6203 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Public Library of Science (PLoS) |
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| spelling | doaj-art-c673b8e9537d4fb88d87e21ffb020b432025-08-20T02:31:41ZengPublic Library of Science (PLoS)PLoS ONE1932-62032024-01-01193e029091310.1371/journal.pone.0290913Seroepidemiology of SARS-CoV-2 in a cohort of pregnant women and their infants in Uganda and Malawi.Lauren HookhamLiberty CantrellStephen CoseBridget FreyneLuis GadamaEsther ImedeKondwani KawazaSamantha LissauerPhillipa MusokeVictoria NankabirwaMusa SekikuboHalvor SommerfeltMerryn VoyseyKirsty Le DoareperiCOVID Consortium<h4>Background</h4>Data on SARS-CoV-2 infection in pregnancy and infancy has accumulated throughout the course of the pandemic, though evidence regarding asymptomatic SARS-CoV-2 infection and adverse birth outcomes are scarce. Limited information is available from countries in sub-Saharan Africa (SSA). The pregnant woman and infant COVID in Africa study (PeriCOVID Africa) is a South-South-North partnership involving hospitals and health centres in five countries: Malawi, Uganda, Mozambique, The Gambia, and Kenya. The study leveraged data from three ongoing prospective cohort studies: Preparing for Group B Streptococcal Vaccines (GBS PREPARE), SARS-CoV-2 infection and COVID-19 in women and their infants in Kampala and Mukono (COMAC) and Pregnancy Care Integrating Translational Science Everywhere (PRECISE). In this paper we describe the seroepidemiology of SARS-CoV-2 infection in pregnant women enrolled in sites in Uganda and Malawi, and the impact of SARS-CoV-2 infection on pregnancy and infant outcomes.<h4>Outcome</h4>Seroprevalence of SARS-CoV-2 antibodies in maternal blood, reported as the proportion of seropositive women by study site and wave of COVID-19 within each country.<h4>Methods</h4>The PeriCOVID study was a prospective mother-infant cohort study that recruited pregnant women at any gestation antenatally or on the day of delivery. Maternal and cord blood samples were tested for SARS-CoV-2 antibodies using Wantai and Euroimmune ELISA. In periCOVID Uganda and Malawi nose and throat swabs for SARS-Cov-2 RT-PCR were obtained.<h4>Results</h4>In total, 1379 women were enrolled, giving birth to 1387 infants. Overall, 63% of pregnant women had a SARS-CoV-2 positive serology. Over subsequent waves (delta and omicron), in the absence of vaccination, seropositivity rose from 20% to over 80%. The placental transfer GMR was 1.7, indicating active placental transfer of anti-spike IgG. There was no association between SARS-CoV-2 antibody positivity and adverse pregnancy or infancy outcomes.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0290913&type=printable |
| spellingShingle | Lauren Hookham Liberty Cantrell Stephen Cose Bridget Freyne Luis Gadama Esther Imede Kondwani Kawaza Samantha Lissauer Phillipa Musoke Victoria Nankabirwa Musa Sekikubo Halvor Sommerfelt Merryn Voysey Kirsty Le Doare periCOVID Consortium Seroepidemiology of SARS-CoV-2 in a cohort of pregnant women and their infants in Uganda and Malawi. PLoS ONE |
| title | Seroepidemiology of SARS-CoV-2 in a cohort of pregnant women and their infants in Uganda and Malawi. |
| title_full | Seroepidemiology of SARS-CoV-2 in a cohort of pregnant women and their infants in Uganda and Malawi. |
| title_fullStr | Seroepidemiology of SARS-CoV-2 in a cohort of pregnant women and their infants in Uganda and Malawi. |
| title_full_unstemmed | Seroepidemiology of SARS-CoV-2 in a cohort of pregnant women and their infants in Uganda and Malawi. |
| title_short | Seroepidemiology of SARS-CoV-2 in a cohort of pregnant women and their infants in Uganda and Malawi. |
| title_sort | seroepidemiology of sars cov 2 in a cohort of pregnant women and their infants in uganda and malawi |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0290913&type=printable |
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