Influence of kaempferol against garri meal tainted with vacuum gas oil induced nephro- and neurotoxicity
The present study investigated the defensive effect of kaempferol in the tissues of Wistar rats fed with vacuum gas oil polluted garri diet. The rats (30) were grouped into six (n = 5): Group 1: Control: Fried garri normal diet (FGND). Group 2 and 3 were given FGND and treated with 50 and 100 mg/kg...
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Elsevier
2024-12-01
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| Series: | Food Chemistry Advances |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772753X24001898 |
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| author | Joel Okpoghono Busade Adebayo Agbetuyi Toritseju Eyide Innocent Onyesom |
| author_facet | Joel Okpoghono Busade Adebayo Agbetuyi Toritseju Eyide Innocent Onyesom |
| author_sort | Joel Okpoghono |
| collection | DOAJ |
| description | The present study investigated the defensive effect of kaempferol in the tissues of Wistar rats fed with vacuum gas oil polluted garri diet. The rats (30) were grouped into six (n = 5): Group 1: Control: Fried garri normal diet (FGND). Group 2 and 3 were given FGND and treated with 50 and 100 mg/kg b. wt of kaempferol. Group 4: Fried garri diet with vacuum gas oil (FGD-VGO) only. Group 5 and 6 were given FGD-VGO then treated with 50 and 100 mg/kg b. wt. of kaempferol. The rats were euthanized using carbon dioxide after experimental period of 28 days. The tissues (kidney and brain) were excised for biochemical assays. The results indicated a significant decrease in antioxidant markers (superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione-s-transferase, GST), Na+/K+-ATPase, percentage of fragmented deoxyribonucleic acid (DNA) and increase malondialdehyde (MDA) in the tissues of rats in group 4 compared to the other groups. However, treatment with kaempferol significantly decreased MDA level and increased antioxidant markers in the tissues of rats fed FGD-VGO. In conclusion, the data obtained may point out to kaempferol playing a crucial role as an antioxidant against garri meal tainted with vacuum gas oil in Wistar rats. |
| format | Article |
| id | doaj-art-c671aa8df5a748c4a10c0f97debfcea4 |
| institution | OA Journals |
| issn | 2772-753X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
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| series | Food Chemistry Advances |
| spelling | doaj-art-c671aa8df5a748c4a10c0f97debfcea42025-08-20T02:38:39ZengElsevierFood Chemistry Advances2772-753X2024-12-01510079410.1016/j.focha.2024.100794Influence of kaempferol against garri meal tainted with vacuum gas oil induced nephro- and neurotoxicityJoel Okpoghono0Busade Adebayo Agbetuyi1Toritseju Eyide2Innocent Onyesom3Department of Biochemistry, Delta State University of Science and Technology, Ozoro, Delta State, Nigeria; Corresponding author.Department of Chemical Science, Novena University, Ogume, Delta State, NigeriaDepartment of Chemical Science, Novena University, Ogume, Delta State, NigeriaDepartment of Medical Biochemistry, Delta State University, Abraka, Delta State, NigeriaThe present study investigated the defensive effect of kaempferol in the tissues of Wistar rats fed with vacuum gas oil polluted garri diet. The rats (30) were grouped into six (n = 5): Group 1: Control: Fried garri normal diet (FGND). Group 2 and 3 were given FGND and treated with 50 and 100 mg/kg b. wt of kaempferol. Group 4: Fried garri diet with vacuum gas oil (FGD-VGO) only. Group 5 and 6 were given FGD-VGO then treated with 50 and 100 mg/kg b. wt. of kaempferol. The rats were euthanized using carbon dioxide after experimental period of 28 days. The tissues (kidney and brain) were excised for biochemical assays. The results indicated a significant decrease in antioxidant markers (superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione-s-transferase, GST), Na+/K+-ATPase, percentage of fragmented deoxyribonucleic acid (DNA) and increase malondialdehyde (MDA) in the tissues of rats in group 4 compared to the other groups. However, treatment with kaempferol significantly decreased MDA level and increased antioxidant markers in the tissues of rats fed FGD-VGO. In conclusion, the data obtained may point out to kaempferol playing a crucial role as an antioxidant against garri meal tainted with vacuum gas oil in Wistar rats.http://www.sciencedirect.com/science/article/pii/S2772753X24001898Cassava mealFragmented DNAHydrocarbonsOxidative stressVacuum gas oil |
| spellingShingle | Joel Okpoghono Busade Adebayo Agbetuyi Toritseju Eyide Innocent Onyesom Influence of kaempferol against garri meal tainted with vacuum gas oil induced nephro- and neurotoxicity Food Chemistry Advances Cassava meal Fragmented DNA Hydrocarbons Oxidative stress Vacuum gas oil |
| title | Influence of kaempferol against garri meal tainted with vacuum gas oil induced nephro- and neurotoxicity |
| title_full | Influence of kaempferol against garri meal tainted with vacuum gas oil induced nephro- and neurotoxicity |
| title_fullStr | Influence of kaempferol against garri meal tainted with vacuum gas oil induced nephro- and neurotoxicity |
| title_full_unstemmed | Influence of kaempferol against garri meal tainted with vacuum gas oil induced nephro- and neurotoxicity |
| title_short | Influence of kaempferol against garri meal tainted with vacuum gas oil induced nephro- and neurotoxicity |
| title_sort | influence of kaempferol against garri meal tainted with vacuum gas oil induced nephro and neurotoxicity |
| topic | Cassava meal Fragmented DNA Hydrocarbons Oxidative stress Vacuum gas oil |
| url | http://www.sciencedirect.com/science/article/pii/S2772753X24001898 |
| work_keys_str_mv | AT joelokpoghono influenceofkaempferolagainstgarrimealtaintedwithvacuumgasoilinducednephroandneurotoxicity AT busadeadebayoagbetuyi influenceofkaempferolagainstgarrimealtaintedwithvacuumgasoilinducednephroandneurotoxicity AT toritsejueyide influenceofkaempferolagainstgarrimealtaintedwithvacuumgasoilinducednephroandneurotoxicity AT innocentonyesom influenceofkaempferolagainstgarrimealtaintedwithvacuumgasoilinducednephroandneurotoxicity |