Efficacy of Heptral® in the treatment of hepatic toxicity induced by cytostatic chemotherapy
The efficacy of Heptral® (ademethionine) was evaluated in the treatment of chemotherapy-induced hepatotoxicity in 19 patients with various malignancies. Four-week administration of oral Heptral® 400 mg twice daily was shown to reduce the level of transaminases to normal values in 10 of 12 patients w...
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| Format: | Article |
| Language: | Russian |
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ABV-press
2014-08-01
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| Series: | Опухоли женской репродуктивной системы |
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| Online Access: | https://ojrs.abvpress.ru/ojrs/article/view/230 |
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| author | A. V. Snegovoy L. V. Manzyuk |
| author_facet | A. V. Snegovoy L. V. Manzyuk |
| author_sort | A. V. Snegovoy |
| collection | DOAJ |
| description | The efficacy of Heptral® (ademethionine) was evaluated in the treatment of chemotherapy-induced hepatotoxicity in 19 patients with various malignancies. Four-week administration of oral Heptral® 400 mg twice daily was shown to reduce the level of transaminases to normal values in 10 of 12 patients with grade 1 toxicity. Longer (2-to-4 month) use of Heptral® was required to normalize the level of transminases in grade 2 hepatotoxicity. The chemotherapy regimen was not changed during the use of this drug. |
| format | Article |
| id | doaj-art-c670bbcd60514a7fae019329ff436e4e |
| institution | DOAJ |
| issn | 1994-4098 1999-8627 |
| language | Russian |
| publishDate | 2014-08-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Опухоли женской репродуктивной системы |
| spelling | doaj-art-c670bbcd60514a7fae019329ff436e4e2025-08-20T03:02:01ZrusABV-pressОпухоли женской репродуктивной системы1994-40981999-86272014-08-0102475210.17650/1994-4098-2010-0-2-47-52246Efficacy of Heptral® in the treatment of hepatic toxicity induced by cytostatic chemotherapyA. V. Snegovoy0L. V. Manzyuk1N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, MoscowN.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, MoscowThe efficacy of Heptral® (ademethionine) was evaluated in the treatment of chemotherapy-induced hepatotoxicity in 19 patients with various malignancies. Four-week administration of oral Heptral® 400 mg twice daily was shown to reduce the level of transaminases to normal values in 10 of 12 patients with grade 1 toxicity. Longer (2-to-4 month) use of Heptral® was required to normalize the level of transminases in grade 2 hepatotoxicity. The chemotherapy regimen was not changed during the use of this drug.https://ojrs.abvpress.ru/ojrs/article/view/230chemotherapyhepatotoxicitytransaminaseademethionine |
| spellingShingle | A. V. Snegovoy L. V. Manzyuk Efficacy of Heptral® in the treatment of hepatic toxicity induced by cytostatic chemotherapy Опухоли женской репродуктивной системы chemotherapy hepatotoxicity transaminase ademethionine |
| title | Efficacy of Heptral® in the treatment of hepatic toxicity induced by cytostatic chemotherapy |
| title_full | Efficacy of Heptral® in the treatment of hepatic toxicity induced by cytostatic chemotherapy |
| title_fullStr | Efficacy of Heptral® in the treatment of hepatic toxicity induced by cytostatic chemotherapy |
| title_full_unstemmed | Efficacy of Heptral® in the treatment of hepatic toxicity induced by cytostatic chemotherapy |
| title_short | Efficacy of Heptral® in the treatment of hepatic toxicity induced by cytostatic chemotherapy |
| title_sort | efficacy of heptral r in the treatment of hepatic toxicity induced by cytostatic chemotherapy |
| topic | chemotherapy hepatotoxicity transaminase ademethionine |
| url | https://ojrs.abvpress.ru/ojrs/article/view/230 |
| work_keys_str_mv | AT avsnegovoy efficacyofheptralinthetreatmentofhepatictoxicityinducedbycytostaticchemotherapy AT lvmanzyuk efficacyofheptralinthetreatmentofhepatictoxicityinducedbycytostaticchemotherapy |