Clinical Implications of Antinuclear Antibody (ANA) and Anti-Ro/Anti-La Antibody Profile in Patients with Primary Sjögren’s Syndrome: A Multicenter Cross-Sectional Study of a National Egyptian Cohort
Tamer A Gheita,1 Yasser Emad,1 Hanan Mohamed Saadany,2 Amira M Ibrahim,3 Rawhya R El Shereef,4 Khaled Abdelgalil,5 Faten Ismail,4 Wael A Abady,6 Shereen Elwan,2 Eiman Abdellatif,7 Fatma Mohammed,8 Omnia ElBayumi,9 Osman Hammam,10 Samar Tharwat,11 Nevin Hammam12 1Rheumatology Department, Faculty of M...
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Dove Medical Press
2025-07-01
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| Series: | Open Access Rheumatology: Research and Reviews |
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| Online Access: | https://www.dovepress.com/clinical-implications-of-antinuclear-antibody-ana-and-anti-roanti-la-a-peer-reviewed-fulltext-article-OARRR |
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| author | Gheita TA Emad Y Saadany HM Ibrahim AM El Shereef RR Abdelgalil K Ismail F Abady WA Elwan S Abdellatif E Mohammed F ElBayumi O Hammam O Tharwat S Hammam N |
| author_facet | Gheita TA Emad Y Saadany HM Ibrahim AM El Shereef RR Abdelgalil K Ismail F Abady WA Elwan S Abdellatif E Mohammed F ElBayumi O Hammam O Tharwat S Hammam N |
| author_sort | Gheita TA |
| collection | DOAJ |
| description | Tamer A Gheita,1 Yasser Emad,1 Hanan Mohamed Saadany,2 Amira M Ibrahim,3 Rawhya R El Shereef,4 Khaled Abdelgalil,5 Faten Ismail,4 Wael A Abady,6 Shereen Elwan,2 Eiman Abdellatif,7 Fatma Mohammed,8 Omnia ElBayumi,9 Osman Hammam,10 Samar Tharwat,11 Nevin Hammam12 1Rheumatology Department, Faculty of Medicine, Cairo University, Cairo, Egypt; 2Rheumatology Department, Faculty of Medicine, Tanta University, Gharbia, Egypt; 3Rheumatology Department, Faculty of Medicine, Kafr El-Sheikh University, Kafr El-Sheikh, Egypt; 4Rheumatology Department, Faculty of Medicine, Minia University, Minia, Egypt; 5Rheumatology Department, Faculty of Medicine, Aswan University, Aswan, Egypt; 6Rheumatology Department, Faculty of Medicine, South Valley University, Qena, Egypt; 7Ophthalmology Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt; 8Faculty of Medicine, Aswan University, Aswan, Egypt; 9Faculty of Medicine, Cairo University, Cairo, Egypt; 10Department of Rheumatology and Rehabilitation, Faculty of Medicine, New Valley University, New Valley, Egypt; 11Internal Medicine Department, Rheumatology Unit, Faculty of Medicine, Mansoura University, Dakahlia, Egypt; 12Rheumatology Department, Faculty of Medicine, Assiut University, Assiut, EgyptCorrespondence: Tamer A Gheita, Rheumatology Department, Faculty of Medicine, Cairo University, Cairo, 11956, Egypt, Tel +2 01004567975, Email gheitamer@kasralainy.edu.eg; gheitamer@hotmail.comBackground: Primary Sjögren’s Syndrome (pSS) is a systemic autoimmune disease that predominantly impacts the exocrine glands. It is characterized by a diverse clinical manifestation and the existence of various autoantibodies. There is a lack of studies assessing the primary pSS phenome driven by anti-Sjögren syndrome autoantibodies in Africa, particularly in Egypt.Objective: This study aims to evaluate the clinical implications of antinuclear antibodies (ANA) and anti-Ro/anti-La autoantibodies in an Egyptian national cohort of pSS patients.Methods: We conducted a cross-sectional analysis of pSS patients, comparing clinical manifestations and disease severity based on serological profiles.Results: A total of 301 pSS patients (mean age: 45.6± 10.2 years; F:M ratio 7.4:1) were included. Patients with positive ANA (59.5%) had a higher prevalence of anti-Ro (p=0.001) and anti-La (p=0.0001) antibodies, along with lower rates of dry eyes (p=0.04) and enlarged parotid glands (p=0.001). Corticosteroid and azathioprine use was more frequent in ANA-positive patients (p=0.017, p=0.003). Double-positive anti-Ro/anti-La patients exhibited higher rates of dry mouth (p=0.045), articular manifestations (p< 0.0001), fibromyalgia (p=0.001), RF positivity (p< 0.001), and C4 consumption (p< 0.001).Conclusion: Patients with pSS exhibit distinct clinical and laboratory profiles based on their autoantibody status, emphasizing the importance of immunological assessment for disease management.Keywords: primary Sjögren’s syndrome, antinuclear antibody, anti-Ro, anti-La, Egypt |
| format | Article |
| id | doaj-art-c66d7929338a443caafd8d16088f68e5 |
| institution | DOAJ |
| issn | 1179-156X |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Open Access Rheumatology: Research and Reviews |
| spelling | doaj-art-c66d7929338a443caafd8d16088f68e52025-08-20T03:13:30ZengDove Medical PressOpen Access Rheumatology: Research and Reviews1179-156X2025-07-01Volume 17Issue 1135146104779Clinical Implications of Antinuclear Antibody (ANA) and Anti-Ro/Anti-La Antibody Profile in Patients with Primary Sj&ouml;gren&rsquo;s Syndrome: A Multicenter Cross-Sectional Study of a National Egyptian CohortGheita TA0Emad YSaadany HM1Ibrahim AM2El Shereef RR3Abdelgalil KIsmail FAbady WA4Elwan S5Abdellatif E6Mohammed FElBayumi O7Hammam O8Tharwat S9Hammam N10RheumatologyRheumatologyRheumatologyRheumatologyRheumatology DepartmentPhysical medicine, Rheumatology and RehabilitationOphthalmologyKasr AlAinyRheumatology and RehabilitationRheumatology and Immunology unit (Internal Medicine Department )Rheumatology and RehabilitationTamer A Gheita,1 Yasser Emad,1 Hanan Mohamed Saadany,2 Amira M Ibrahim,3 Rawhya R El Shereef,4 Khaled Abdelgalil,5 Faten Ismail,4 Wael A Abady,6 Shereen Elwan,2 Eiman Abdellatif,7 Fatma Mohammed,8 Omnia ElBayumi,9 Osman Hammam,10 Samar Tharwat,11 Nevin Hammam12 1Rheumatology Department, Faculty of Medicine, Cairo University, Cairo, Egypt; 2Rheumatology Department, Faculty of Medicine, Tanta University, Gharbia, Egypt; 3Rheumatology Department, Faculty of Medicine, Kafr El-Sheikh University, Kafr El-Sheikh, Egypt; 4Rheumatology Department, Faculty of Medicine, Minia University, Minia, Egypt; 5Rheumatology Department, Faculty of Medicine, Aswan University, Aswan, Egypt; 6Rheumatology Department, Faculty of Medicine, South Valley University, Qena, Egypt; 7Ophthalmology Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt; 8Faculty of Medicine, Aswan University, Aswan, Egypt; 9Faculty of Medicine, Cairo University, Cairo, Egypt; 10Department of Rheumatology and Rehabilitation, Faculty of Medicine, New Valley University, New Valley, Egypt; 11Internal Medicine Department, Rheumatology Unit, Faculty of Medicine, Mansoura University, Dakahlia, Egypt; 12Rheumatology Department, Faculty of Medicine, Assiut University, Assiut, EgyptCorrespondence: Tamer A Gheita, Rheumatology Department, Faculty of Medicine, Cairo University, Cairo, 11956, Egypt, Tel +2 01004567975, Email gheitamer@kasralainy.edu.eg; gheitamer@hotmail.comBackground: Primary Sjögren’s Syndrome (pSS) is a systemic autoimmune disease that predominantly impacts the exocrine glands. It is characterized by a diverse clinical manifestation and the existence of various autoantibodies. There is a lack of studies assessing the primary pSS phenome driven by anti-Sjögren syndrome autoantibodies in Africa, particularly in Egypt.Objective: This study aims to evaluate the clinical implications of antinuclear antibodies (ANA) and anti-Ro/anti-La autoantibodies in an Egyptian national cohort of pSS patients.Methods: We conducted a cross-sectional analysis of pSS patients, comparing clinical manifestations and disease severity based on serological profiles.Results: A total of 301 pSS patients (mean age: 45.6± 10.2 years; F:M ratio 7.4:1) were included. Patients with positive ANA (59.5%) had a higher prevalence of anti-Ro (p=0.001) and anti-La (p=0.0001) antibodies, along with lower rates of dry eyes (p=0.04) and enlarged parotid glands (p=0.001). Corticosteroid and azathioprine use was more frequent in ANA-positive patients (p=0.017, p=0.003). Double-positive anti-Ro/anti-La patients exhibited higher rates of dry mouth (p=0.045), articular manifestations (p< 0.0001), fibromyalgia (p=0.001), RF positivity (p< 0.001), and C4 consumption (p< 0.001).Conclusion: Patients with pSS exhibit distinct clinical and laboratory profiles based on their autoantibody status, emphasizing the importance of immunological assessment for disease management.Keywords: primary Sjögren’s syndrome, antinuclear antibody, anti-Ro, anti-La, Egypthttps://www.dovepress.com/clinical-implications-of-antinuclear-antibody-ana-and-anti-roanti-la-a-peer-reviewed-fulltext-article-OARRRPrimary Sjögren's SyndromeAntinuclear antibodyAnti-Roanti-LaEgypt |
| spellingShingle | Gheita TA Emad Y Saadany HM Ibrahim AM El Shereef RR Abdelgalil K Ismail F Abady WA Elwan S Abdellatif E Mohammed F ElBayumi O Hammam O Tharwat S Hammam N Clinical Implications of Antinuclear Antibody (ANA) and Anti-Ro/Anti-La Antibody Profile in Patients with Primary Sj&ouml;gren&rsquo;s Syndrome: A Multicenter Cross-Sectional Study of a National Egyptian Cohort Open Access Rheumatology: Research and Reviews Primary Sjögren's Syndrome Antinuclear antibody Anti-Ro anti-La Egypt |
| title | Clinical Implications of Antinuclear Antibody (ANA) and Anti-Ro/Anti-La Antibody Profile in Patients with Primary Sj&ouml;gren&rsquo;s Syndrome: A Multicenter Cross-Sectional Study of a National Egyptian Cohort |
| title_full | Clinical Implications of Antinuclear Antibody (ANA) and Anti-Ro/Anti-La Antibody Profile in Patients with Primary Sj&ouml;gren&rsquo;s Syndrome: A Multicenter Cross-Sectional Study of a National Egyptian Cohort |
| title_fullStr | Clinical Implications of Antinuclear Antibody (ANA) and Anti-Ro/Anti-La Antibody Profile in Patients with Primary Sj&ouml;gren&rsquo;s Syndrome: A Multicenter Cross-Sectional Study of a National Egyptian Cohort |
| title_full_unstemmed | Clinical Implications of Antinuclear Antibody (ANA) and Anti-Ro/Anti-La Antibody Profile in Patients with Primary Sj&ouml;gren&rsquo;s Syndrome: A Multicenter Cross-Sectional Study of a National Egyptian Cohort |
| title_short | Clinical Implications of Antinuclear Antibody (ANA) and Anti-Ro/Anti-La Antibody Profile in Patients with Primary Sj&ouml;gren&rsquo;s Syndrome: A Multicenter Cross-Sectional Study of a National Egyptian Cohort |
| title_sort | clinical implications of antinuclear antibody ana and anti ro anti la antibody profile in patients with primary sj amp ouml gren amp rsquo s syndrome a multicenter cross sectional study of a national egyptian cohort |
| topic | Primary Sjögren's Syndrome Antinuclear antibody Anti-Ro anti-La Egypt |
| url | https://www.dovepress.com/clinical-implications-of-antinuclear-antibody-ana-and-anti-roanti-la-a-peer-reviewed-fulltext-article-OARRR |
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