Clinical Implications of Antinuclear Antibody (ANA) and Anti-Ro/Anti-La Antibody Profile in Patients with Primary Sjögren’s Syndrome: A Multicenter Cross-Sectional Study of a National Egyptian Cohort
Tamer A Gheita,1 Yasser Emad,1 Hanan Mohamed Saadany,2 Amira M Ibrahim,3 Rawhya R El Shereef,4 Khaled Abdelgalil,5 Faten Ismail,4 Wael A Abady,6 Shereen Elwan,2 Eiman Abdellatif,7 Fatma Mohammed,8 Omnia ElBayumi,9 Osman Hammam,10 Samar Tharwat,11 Nevin Hammam12 1Rheumatology Department, Faculty of M...
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| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2025-07-01
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| Series: | Open Access Rheumatology: Research and Reviews |
| Subjects: | |
| Online Access: | https://www.dovepress.com/clinical-implications-of-antinuclear-antibody-ana-and-anti-roanti-la-a-peer-reviewed-fulltext-article-OARRR |
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| Summary: | Tamer A Gheita,1 Yasser Emad,1 Hanan Mohamed Saadany,2 Amira M Ibrahim,3 Rawhya R El Shereef,4 Khaled Abdelgalil,5 Faten Ismail,4 Wael A Abady,6 Shereen Elwan,2 Eiman Abdellatif,7 Fatma Mohammed,8 Omnia ElBayumi,9 Osman Hammam,10 Samar Tharwat,11 Nevin Hammam12 1Rheumatology Department, Faculty of Medicine, Cairo University, Cairo, Egypt; 2Rheumatology Department, Faculty of Medicine, Tanta University, Gharbia, Egypt; 3Rheumatology Department, Faculty of Medicine, Kafr El-Sheikh University, Kafr El-Sheikh, Egypt; 4Rheumatology Department, Faculty of Medicine, Minia University, Minia, Egypt; 5Rheumatology Department, Faculty of Medicine, Aswan University, Aswan, Egypt; 6Rheumatology Department, Faculty of Medicine, South Valley University, Qena, Egypt; 7Ophthalmology Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt; 8Faculty of Medicine, Aswan University, Aswan, Egypt; 9Faculty of Medicine, Cairo University, Cairo, Egypt; 10Department of Rheumatology and Rehabilitation, Faculty of Medicine, New Valley University, New Valley, Egypt; 11Internal Medicine Department, Rheumatology Unit, Faculty of Medicine, Mansoura University, Dakahlia, Egypt; 12Rheumatology Department, Faculty of Medicine, Assiut University, Assiut, EgyptCorrespondence: Tamer A Gheita, Rheumatology Department, Faculty of Medicine, Cairo University, Cairo, 11956, Egypt, Tel +2 01004567975, Email gheitamer@kasralainy.edu.eg; gheitamer@hotmail.comBackground: Primary Sjögren’s Syndrome (pSS) is a systemic autoimmune disease that predominantly impacts the exocrine glands. It is characterized by a diverse clinical manifestation and the existence of various autoantibodies. There is a lack of studies assessing the primary pSS phenome driven by anti-Sjögren syndrome autoantibodies in Africa, particularly in Egypt.Objective: This study aims to evaluate the clinical implications of antinuclear antibodies (ANA) and anti-Ro/anti-La autoantibodies in an Egyptian national cohort of pSS patients.Methods: We conducted a cross-sectional analysis of pSS patients, comparing clinical manifestations and disease severity based on serological profiles.Results: A total of 301 pSS patients (mean age: 45.6± 10.2 years; F:M ratio 7.4:1) were included. Patients with positive ANA (59.5%) had a higher prevalence of anti-Ro (p=0.001) and anti-La (p=0.0001) antibodies, along with lower rates of dry eyes (p=0.04) and enlarged parotid glands (p=0.001). Corticosteroid and azathioprine use was more frequent in ANA-positive patients (p=0.017, p=0.003). Double-positive anti-Ro/anti-La patients exhibited higher rates of dry mouth (p=0.045), articular manifestations (p< 0.0001), fibromyalgia (p=0.001), RF positivity (p< 0.001), and C4 consumption (p< 0.001).Conclusion: Patients with pSS exhibit distinct clinical and laboratory profiles based on their autoantibody status, emphasizing the importance of immunological assessment for disease management.Keywords: primary Sjögren’s syndrome, antinuclear antibody, anti-Ro, anti-La, Egypt |
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| ISSN: | 1179-156X |