Serum trimethylamine N-oxide and its precursors are associated with the occurrence of mild cognition impairment as well as changes in neurocognitive status
BackgroundThis study aims to examine the association between gut microbe-dependent trimethylamine N-oxide (TMAO) and its precursors (choline, betaine, and carnitine) levels and mild cognition impairment (MCI), alongside changes in the Chinese version of the Montreal Cognitive Assessment-Basic (ΔMoCA...
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Frontiers Media S.A.
2024-11-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2024.1461942/full |
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| author | He Bai Yao Zhang Peiying Tian Yani Wu Ruiheng Peng Bin Liang Wenli Ruan Enmao Cai Ying Lu Mingfeng Ma Liqiang Zheng Liqiang Zheng |
| author_facet | He Bai Yao Zhang Peiying Tian Yani Wu Ruiheng Peng Bin Liang Wenli Ruan Enmao Cai Ying Lu Mingfeng Ma Liqiang Zheng Liqiang Zheng |
| author_sort | He Bai |
| collection | DOAJ |
| description | BackgroundThis study aims to examine the association between gut microbe-dependent trimethylamine N-oxide (TMAO) and its precursors (choline, betaine, and carnitine) levels and mild cognition impairment (MCI), alongside changes in the Chinese version of the Montreal Cognitive Assessment-Basic (ΔMoCA-BC) score in rural adults.MethodsDrawing data from a large-scale epidemiological study conducted in rural areas of Fuxin County, Liaoning Province, China. 1,535 participants free from brain-related ailments were initially surveyed. MCI was assessed through the MoCA-BC score. Logistic regression models and restricted cubic spline were used to investigate the association between TMAO and its precursors levels and MCI. Additionally, the association between TMAO and its precursors levels and ΔMoCA-BC was analyzed using a generalized linear model in the longitudinal study.ResultsThe average age of the study participants was 58.6 ± 9.4 years and the prevalence rate of MCI was 34.5%. With the second quartile as the reference in the logistic regression model, the OR for risk of MCI in the highest quartile for TMAO, betaine, and carnitine was 1.685 (95% CI: 1.232–2.303, p = 0.001), 2.367 (95% CI: 1.722–3.255, p < 0.001), and 2.239 (95% CI: 1.742–3.295, p < 0.001), respectively. The OR of choline for the highest versus lowest quartile was 2.711 (95% CI: 2.012–3.817, p < 0.001) for the risk of MCI. We find a J-shaped association between betaine (Pnon-linear = 0.001) and carnitine (Pnon-linear = 0.003) levels and MCI. Furthermore, TMAO and its precursors levels were associated with ΔMoCA-BC in the third and fourth quartiles group (All p < 0.05).ConclusionThe findings suggest the existence of an optimal concentration range for serum levels of TMAO, betaine, and carnitine that mitigates MCI risk, paving the way for enhanced dietary interventions aimed at preventing and treating MCI. |
| format | Article |
| id | doaj-art-c66831db4f45423ebb47f7b031221be2 |
| institution | Kabale University |
| issn | 2296-861X |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Nutrition |
| spelling | doaj-art-c66831db4f45423ebb47f7b031221be22024-11-28T04:20:59ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2024-11-011110.3389/fnut.2024.14619421461942Serum trimethylamine N-oxide and its precursors are associated with the occurrence of mild cognition impairment as well as changes in neurocognitive statusHe Bai0Yao Zhang1Peiying Tian2Yani Wu3Ruiheng Peng4Bin Liang5Wenli Ruan6Enmao Cai7Ying Lu8Mingfeng Ma9Liqiang Zheng10Liqiang Zheng11School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Endocrinology, Shengjing Hospital of China Medical University, Shenyang, ChinaDepartment of Gastroenterology, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, ChinaSchool of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaSchool of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Cardiovascular Medicine, Second Hospital of Shanxi Medical University, Taiyuan, ChinaDepartment of Physical and Chemical, Changning District Center for Disease Control and Prevention, Shanghai, ChinaDepartment of Physical and Chemical, Changning District Center for Disease Control and Prevention, Shanghai, ChinaDepartment of Physical and Chemical, Changning District Center for Disease Control and Prevention, Shanghai, ChinaDepartment of Cardiovascular Medicine, Fenyang Hospital of Shanxi Province, Fenyang, ChinaSchool of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaMinistry of Education-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaBackgroundThis study aims to examine the association between gut microbe-dependent trimethylamine N-oxide (TMAO) and its precursors (choline, betaine, and carnitine) levels and mild cognition impairment (MCI), alongside changes in the Chinese version of the Montreal Cognitive Assessment-Basic (ΔMoCA-BC) score in rural adults.MethodsDrawing data from a large-scale epidemiological study conducted in rural areas of Fuxin County, Liaoning Province, China. 1,535 participants free from brain-related ailments were initially surveyed. MCI was assessed through the MoCA-BC score. Logistic regression models and restricted cubic spline were used to investigate the association between TMAO and its precursors levels and MCI. Additionally, the association between TMAO and its precursors levels and ΔMoCA-BC was analyzed using a generalized linear model in the longitudinal study.ResultsThe average age of the study participants was 58.6 ± 9.4 years and the prevalence rate of MCI was 34.5%. With the second quartile as the reference in the logistic regression model, the OR for risk of MCI in the highest quartile for TMAO, betaine, and carnitine was 1.685 (95% CI: 1.232–2.303, p = 0.001), 2.367 (95% CI: 1.722–3.255, p < 0.001), and 2.239 (95% CI: 1.742–3.295, p < 0.001), respectively. The OR of choline for the highest versus lowest quartile was 2.711 (95% CI: 2.012–3.817, p < 0.001) for the risk of MCI. We find a J-shaped association between betaine (Pnon-linear = 0.001) and carnitine (Pnon-linear = 0.003) levels and MCI. Furthermore, TMAO and its precursors levels were associated with ΔMoCA-BC in the third and fourth quartiles group (All p < 0.05).ConclusionThe findings suggest the existence of an optimal concentration range for serum levels of TMAO, betaine, and carnitine that mitigates MCI risk, paving the way for enhanced dietary interventions aimed at preventing and treating MCI.https://www.frontiersin.org/articles/10.3389/fnut.2024.1461942/fulltrimethylamine N-oxideTMAOmild cognition impairmentMCIMoCA-BCcholine |
| spellingShingle | He Bai Yao Zhang Peiying Tian Yani Wu Ruiheng Peng Bin Liang Wenli Ruan Enmao Cai Ying Lu Mingfeng Ma Liqiang Zheng Liqiang Zheng Serum trimethylamine N-oxide and its precursors are associated with the occurrence of mild cognition impairment as well as changes in neurocognitive status Frontiers in Nutrition trimethylamine N-oxide TMAO mild cognition impairment MCI MoCA-BC choline |
| title | Serum trimethylamine N-oxide and its precursors are associated with the occurrence of mild cognition impairment as well as changes in neurocognitive status |
| title_full | Serum trimethylamine N-oxide and its precursors are associated with the occurrence of mild cognition impairment as well as changes in neurocognitive status |
| title_fullStr | Serum trimethylamine N-oxide and its precursors are associated with the occurrence of mild cognition impairment as well as changes in neurocognitive status |
| title_full_unstemmed | Serum trimethylamine N-oxide and its precursors are associated with the occurrence of mild cognition impairment as well as changes in neurocognitive status |
| title_short | Serum trimethylamine N-oxide and its precursors are associated with the occurrence of mild cognition impairment as well as changes in neurocognitive status |
| title_sort | serum trimethylamine n oxide and its precursors are associated with the occurrence of mild cognition impairment as well as changes in neurocognitive status |
| topic | trimethylamine N-oxide TMAO mild cognition impairment MCI MoCA-BC choline |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2024.1461942/full |
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