Single component organic photosensitizer for tumor Photodynamic/Photothermal immunotherapy via apoptosis and pyroptosis
Pyroptosis is the programmed cell death of inflammation and an effective way to eliminate tumors. However, how to trigger the pyroptosis of tumor cells is a great challenge. Herein, a JNC nanoparticles (NPs) synchronous shared fluorescence imaging (FLI), oxygen-dependent reduction type Ⅰ photodynami...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-03-01
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| Series: | Materials & Design |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S026412752500067X |
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| author | Miao-Yan Xu Jie Zeng Xin-Hao Han Duo-Duo Wei Bing Fan Xin‑Hui Qu Shaorong Huang Xiao-Jian Han |
| author_facet | Miao-Yan Xu Jie Zeng Xin-Hao Han Duo-Duo Wei Bing Fan Xin‑Hui Qu Shaorong Huang Xiao-Jian Han |
| author_sort | Miao-Yan Xu |
| collection | DOAJ |
| description | Pyroptosis is the programmed cell death of inflammation and an effective way to eliminate tumors. However, how to trigger the pyroptosis of tumor cells is a great challenge. Herein, a JNC nanoparticles (NPs) synchronous shared fluorescence imaging (FLI), oxygen-dependent reduction type Ⅰ photodynamic therapy (PDT) and high-efficiency photothermal therapy (PTT) were prepared. Furthermore, JNC NPs + Laser has excellent tumor killing ability in vitro and in vivo. The mechanism of cell death induced by JNC NPs + Laser was closely related to mitochondrial apoptosis and pyroptosis. Moreover, JNC NPs + Laser can induce immunogenic cell death (ICD) to improve the maturation of dendritic cells (DCs) and present antigens to T cells, which high-effectively eliminate tumor lung metastasis. This finding provided a single component organic photosensitizer for tumor photodynamic/photothermal immunotherapy via apoptosis and pyroptosis. |
| format | Article |
| id | doaj-art-c664c3bf4ee54eecb221428bba8f40e0 |
| institution | Kabale University |
| issn | 0264-1275 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials & Design |
| spelling | doaj-art-c664c3bf4ee54eecb221428bba8f40e02025-01-31T05:10:04ZengElsevierMaterials & Design0264-12752025-03-01251113647Single component organic photosensitizer for tumor Photodynamic/Photothermal immunotherapy via apoptosis and pyroptosisMiao-Yan Xu0Jie Zeng1Xin-Hao Han2Duo-Duo Wei3Bing Fan4Xin‑Hui Qu5Shaorong Huang6Xiao-Jian Han7Institute of Geriatrics, Jiangxi Provincial People’s Hospital, the First Affiliated Hospital of Nanchang Medical College, Nanchang 330006, Jiangxi, People's Republic of China; School of Pharmacy, Jiangxi Medical College, Nanchang University, Nanchang 330006, Jiangxi, People's Republic of ChinaInstitute of Geriatrics, Jiangxi Provincial People’s Hospital, the First Affiliated Hospital of Nanchang Medical College, Nanchang 330006, Jiangxi, People's Republic of China; School of Pharmacy, Jiangxi Medical College, Nanchang University, Nanchang 330006, Jiangxi, People's Republic of ChinaInstitute of Geriatrics, Jiangxi Provincial People’s Hospital, the First Affiliated Hospital of Nanchang Medical College, Nanchang 330006, Jiangxi, People's Republic of ChinaInstitute of Geriatrics, Jiangxi Provincial People’s Hospital, the First Affiliated Hospital of Nanchang Medical College, Nanchang 330006, Jiangxi, People's Republic of China; School of Pharmacy, Jiangxi Medical College, Nanchang University, Nanchang 330006, Jiangxi, People's Republic of ChinaDepartment of Radiology, Jiangxi Provincial People’s Hospital, the First Affiliated Hospital of Nanchang Medical College, Nanchang 330006, Jiangxi, People's Republic of ChinaThe Second Department of Neurology, Jiangxi Provincial People’s Hospital, the First Affiliated Hospital of Nanchang Medical College, Nanchang 330006, Jiangxi, People's Republic of ChinaInstitute of Geriatrics, Jiangxi Provincial People’s Hospital, the First Affiliated Hospital of Nanchang Medical College, Nanchang 330006, Jiangxi, People's Republic of China; Corresponding authors.Institute of Geriatrics, Jiangxi Provincial People’s Hospital, the First Affiliated Hospital of Nanchang Medical College, Nanchang 330006, Jiangxi, People's Republic of China; The Second Department of Neurology, Jiangxi Provincial People’s Hospital, the First Affiliated Hospital of Nanchang Medical College, Nanchang 330006, Jiangxi, People's Republic of China; Corresponding authors.Pyroptosis is the programmed cell death of inflammation and an effective way to eliminate tumors. However, how to trigger the pyroptosis of tumor cells is a great challenge. Herein, a JNC nanoparticles (NPs) synchronous shared fluorescence imaging (FLI), oxygen-dependent reduction type Ⅰ photodynamic therapy (PDT) and high-efficiency photothermal therapy (PTT) were prepared. Furthermore, JNC NPs + Laser has excellent tumor killing ability in vitro and in vivo. The mechanism of cell death induced by JNC NPs + Laser was closely related to mitochondrial apoptosis and pyroptosis. Moreover, JNC NPs + Laser can induce immunogenic cell death (ICD) to improve the maturation of dendritic cells (DCs) and present antigens to T cells, which high-effectively eliminate tumor lung metastasis. This finding provided a single component organic photosensitizer for tumor photodynamic/photothermal immunotherapy via apoptosis and pyroptosis.http://www.sciencedirect.com/science/article/pii/S026412752500067XPhotosensitizersPhotothermal therapyType Ι photodynamic therapyPyroptosisImmunotherapy |
| spellingShingle | Miao-Yan Xu Jie Zeng Xin-Hao Han Duo-Duo Wei Bing Fan Xin‑Hui Qu Shaorong Huang Xiao-Jian Han Single component organic photosensitizer for tumor Photodynamic/Photothermal immunotherapy via apoptosis and pyroptosis Materials & Design Photosensitizers Photothermal therapy Type Ι photodynamic therapy Pyroptosis Immunotherapy |
| title | Single component organic photosensitizer for tumor Photodynamic/Photothermal immunotherapy via apoptosis and pyroptosis |
| title_full | Single component organic photosensitizer for tumor Photodynamic/Photothermal immunotherapy via apoptosis and pyroptosis |
| title_fullStr | Single component organic photosensitizer for tumor Photodynamic/Photothermal immunotherapy via apoptosis and pyroptosis |
| title_full_unstemmed | Single component organic photosensitizer for tumor Photodynamic/Photothermal immunotherapy via apoptosis and pyroptosis |
| title_short | Single component organic photosensitizer for tumor Photodynamic/Photothermal immunotherapy via apoptosis and pyroptosis |
| title_sort | single component organic photosensitizer for tumor photodynamic photothermal immunotherapy via apoptosis and pyroptosis |
| topic | Photosensitizers Photothermal therapy Type Ι photodynamic therapy Pyroptosis Immunotherapy |
| url | http://www.sciencedirect.com/science/article/pii/S026412752500067X |
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