Enterovirus D68-associated respiratory and neurological illness in Spain, 2014–2018
During 2014, enterovirus D68 (EV-D68) outbreaks were described globally, causing severe respiratory diseases in children and, in some cases, subsequent paralysis. In this study, the type characterization of enterovirus (EV) detected in respiratory illnesses and the epidemiology and clinical associat...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2019-01-01
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| Series: | Emerging Microbes and Infections |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/22221751.2019.1668243 |
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| author | Rubén González-Sanz Irene Taravillo Jordi Reina Ana Navascués Antonio Moreno-Docón Maitane Aranzamendi María Pilar Romero Margarita del Cuerpo Carmen Pérez-González Sonia Pérez-Castro Almudena Otero María Cabrerizo |
| author_facet | Rubén González-Sanz Irene Taravillo Jordi Reina Ana Navascués Antonio Moreno-Docón Maitane Aranzamendi María Pilar Romero Margarita del Cuerpo Carmen Pérez-González Sonia Pérez-Castro Almudena Otero María Cabrerizo |
| author_sort | Rubén González-Sanz |
| collection | DOAJ |
| description | During 2014, enterovirus D68 (EV-D68) outbreaks were described globally, causing severe respiratory diseases in children and, in some cases, subsequent paralysis. In this study, the type characterization of enterovirus (EV) detected in respiratory illnesses and the epidemiology and clinical association of EV-D68 infections in Spain over a five-year period were described. A total of 546 EV-positive samples from hospitalized patients with respiratory infections were included. EV-D68 was the most frequently detected type (46.6%, 191/410 typed EV). Other EV from species A (25.1%), B (27.8%) and C (0.5%) were also identified. EV-D68 infections were more associated with bronchitis while EV-A/B types were more frequent in upper respiratory illness (p < 0.01). EV-D68 was also detected in patients with neurological symptoms (nine meningitis/meningoencephalitis and eight acute flaccid paralysis cases). Phylogenetic analysis of 3′-VP1 region showed most Spanish EV-D68 sequences from 2014 to 2016 belonged to subclades B2/B3, as other American and European strains circulating during the same period. However, those detected in 2017 and 2018 clustered to the emerged subclade D1. In summary, different EV can cause respiratory infections but EV-D68 was the most prevalent, with several strains circulating in Spain at least since 2014. Association between EV-D68 infection and neurological disease was also described. |
| format | Article |
| id | doaj-art-c662ebf19d5c4abcb2fe4741af042c4c |
| institution | OA Journals |
| issn | 2222-1751 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Emerging Microbes and Infections |
| spelling | doaj-art-c662ebf19d5c4abcb2fe4741af042c4c2025-08-20T02:26:09ZengTaylor & Francis GroupEmerging Microbes and Infections2222-17512019-01-01811438144410.1080/22221751.2019.1668243Enterovirus D68-associated respiratory and neurological illness in Spain, 2014–2018Rubén González-Sanz0Irene Taravillo1Jordi Reina2Ana Navascués3Antonio Moreno-Docón4Maitane Aranzamendi5María Pilar Romero6Margarita del Cuerpo7Carmen Pérez-González8Sonia Pérez-Castro9Almudena Otero10María Cabrerizo11Enterovirus Unit, National Centre for Microbiology, Instituto de Salud Carlos III, Madrid, SpainEnterovirus Unit, National Centre for Microbiology, Instituto de Salud Carlos III, Madrid, SpainHospital Son Espases, Palma de Mallorca, SpainComplejo Hospitalario de Navarra, Navarra, SpainHospital Virgen de la Arrixaca, Murcia, SpainHospital Universitario Cruces, Biocruces Bizkaia Health Research Institute, Bilbao, SpainHospital La Paz, Madrid, SpainHospital Santa Creu i Sant Pau, Barcelona, SpainHospital Dr. Negrín, Las Palmas de Gran Canaria, SpainServicio de Microbiología, Complexo Hospitalario Universitario de Vigo (CHUVI), Sergas, Vigo, SpainEnterovirus Unit, National Centre for Microbiology, Instituto de Salud Carlos III, Madrid, SpainEnterovirus Unit, National Centre for Microbiology, Instituto de Salud Carlos III, Madrid, SpainDuring 2014, enterovirus D68 (EV-D68) outbreaks were described globally, causing severe respiratory diseases in children and, in some cases, subsequent paralysis. In this study, the type characterization of enterovirus (EV) detected in respiratory illnesses and the epidemiology and clinical association of EV-D68 infections in Spain over a five-year period were described. A total of 546 EV-positive samples from hospitalized patients with respiratory infections were included. EV-D68 was the most frequently detected type (46.6%, 191/410 typed EV). Other EV from species A (25.1%), B (27.8%) and C (0.5%) were also identified. EV-D68 infections were more associated with bronchitis while EV-A/B types were more frequent in upper respiratory illness (p < 0.01). EV-D68 was also detected in patients with neurological symptoms (nine meningitis/meningoencephalitis and eight acute flaccid paralysis cases). Phylogenetic analysis of 3′-VP1 region showed most Spanish EV-D68 sequences from 2014 to 2016 belonged to subclades B2/B3, as other American and European strains circulating during the same period. However, those detected in 2017 and 2018 clustered to the emerged subclade D1. In summary, different EV can cause respiratory infections but EV-D68 was the most prevalent, with several strains circulating in Spain at least since 2014. Association between EV-D68 infection and neurological disease was also described.https://www.tandfonline.com/doi/10.1080/22221751.2019.1668243Enterovirusenterovirus D68respiratory infectionsacute flaccid paralysisphylogenetic analysis |
| spellingShingle | Rubén González-Sanz Irene Taravillo Jordi Reina Ana Navascués Antonio Moreno-Docón Maitane Aranzamendi María Pilar Romero Margarita del Cuerpo Carmen Pérez-González Sonia Pérez-Castro Almudena Otero María Cabrerizo Enterovirus D68-associated respiratory and neurological illness in Spain, 2014–2018 Emerging Microbes and Infections Enterovirus enterovirus D68 respiratory infections acute flaccid paralysis phylogenetic analysis |
| title | Enterovirus D68-associated respiratory and neurological illness in Spain, 2014–2018 |
| title_full | Enterovirus D68-associated respiratory and neurological illness in Spain, 2014–2018 |
| title_fullStr | Enterovirus D68-associated respiratory and neurological illness in Spain, 2014–2018 |
| title_full_unstemmed | Enterovirus D68-associated respiratory and neurological illness in Spain, 2014–2018 |
| title_short | Enterovirus D68-associated respiratory and neurological illness in Spain, 2014–2018 |
| title_sort | enterovirus d68 associated respiratory and neurological illness in spain 2014 2018 |
| topic | Enterovirus enterovirus D68 respiratory infections acute flaccid paralysis phylogenetic analysis |
| url | https://www.tandfonline.com/doi/10.1080/22221751.2019.1668243 |
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