T-PLL Presenting with an Indolent Course
T-cell prolymphocytic leukemia (T-PLL) is a rare, mature T-cell leukemia which usually presents with aggressive behavior. We report an asymptomatic T-PLL patient diagnosed by clinical features, lymphocyte morphology, and flow cytometry. Incidentally, she was found to have lymphocytosis and lymphaden...
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| Format: | Article |
| Language: | English |
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Wiley
2024-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2024/7310135 |
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| _version_ | 1832546219277156352 |
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| author | Arsa Thammahong Narittee Sukswai Chantana Polprasert |
| author_facet | Arsa Thammahong Narittee Sukswai Chantana Polprasert |
| author_sort | Arsa Thammahong |
| collection | DOAJ |
| description | T-cell prolymphocytic leukemia (T-PLL) is a rare, mature T-cell leukemia which usually presents with aggressive behavior. We report an asymptomatic T-PLL patient diagnosed by clinical features, lymphocyte morphology, and flow cytometry. Incidentally, she was found to have lymphocytosis and lymphadenopathy. Flow cytometry from blood revealed an abnormally increased CD4+ T-cell population. T-cell receptor clonality assessment by next-generation sequencing revealed a dominant clone in the ß-chain constant region. No pathogenic mutations in 25 lymphoma-related genes were found. Due to her asymptomatic T-PLL disease, we observed her clinical situation and blood count every three months for at least one year. |
| format | Article |
| id | doaj-art-c65d2e4b81e04a13851cf522bd203005 |
| institution | Kabale University |
| issn | 2090-6579 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-c65d2e4b81e04a13851cf522bd2030052025-02-03T07:23:37ZengWileyCase Reports in Hematology2090-65792024-01-01202410.1155/2024/7310135T-PLL Presenting with an Indolent CourseArsa Thammahong0Narittee Sukswai1Chantana Polprasert2Department of MedicinePrecision Pathology of Neoplasia Research GroupDepartment of MedicineT-cell prolymphocytic leukemia (T-PLL) is a rare, mature T-cell leukemia which usually presents with aggressive behavior. We report an asymptomatic T-PLL patient diagnosed by clinical features, lymphocyte morphology, and flow cytometry. Incidentally, she was found to have lymphocytosis and lymphadenopathy. Flow cytometry from blood revealed an abnormally increased CD4+ T-cell population. T-cell receptor clonality assessment by next-generation sequencing revealed a dominant clone in the ß-chain constant region. No pathogenic mutations in 25 lymphoma-related genes were found. Due to her asymptomatic T-PLL disease, we observed her clinical situation and blood count every three months for at least one year.http://dx.doi.org/10.1155/2024/7310135 |
| spellingShingle | Arsa Thammahong Narittee Sukswai Chantana Polprasert T-PLL Presenting with an Indolent Course Case Reports in Hematology |
| title | T-PLL Presenting with an Indolent Course |
| title_full | T-PLL Presenting with an Indolent Course |
| title_fullStr | T-PLL Presenting with an Indolent Course |
| title_full_unstemmed | T-PLL Presenting with an Indolent Course |
| title_short | T-PLL Presenting with an Indolent Course |
| title_sort | t pll presenting with an indolent course |
| url | http://dx.doi.org/10.1155/2024/7310135 |
| work_keys_str_mv | AT arsathammahong tpllpresentingwithanindolentcourse AT naritteesukswai tpllpresentingwithanindolentcourse AT chantanapolprasert tpllpresentingwithanindolentcourse |