Human dental follicle stem cell-derived exosomes reduce root resorption by inhibiting periodontal ligament cell pyroptosis

Human dental follicle stem cell-derived exosomes reduce root resorption by inhibiting periodontal ligament cell pyroptosis

Abstract Background To explore the therapeutic effects and mechanisms of the exosomes derived from dental follicle stem cells (DFSC-Exos) in reducing osteoclastogenesis and root resorption (RR) by inhibiting periodontal ligament cell (PDLC) pyroptosis. Methods DFSC-Exos, with force stimulation (Forc...

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Bibliographic Details
Main Authors: Xinyi Li, Xinyang Liu, Jianing Zhou, Ping Zhang, Song Chen, Ding Bai
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Stem Cell Research & Therapy
Subjects:
Periodontal ligament
Exosome
Pyroptosis
Root resorption
Osteoclastogenesis
Macrophage activation
Online Access:https://doi.org/10.1186/s13287-025-04216-6
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