Intensity-Modulated Radiotherapy for a Rendu-Osler-Weber Disease Patient with Recurrent Severe Epistaxis: A Case Report
We present a case of a Rendu-Osler-Weber disease patient with recurrent life threatening epistaxis demanding multiple blood transfusions despite of repetitive endoscopic laser and electrocoagulations, endovascular embolisation, septodermoplasty, and long-term intranasal dressings. As alternative tre...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2010-01-01
|
| Series: | Case Reports in Medicine |
| Online Access: | http://dx.doi.org/10.1155/2010/321835 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832563592435597312 |
|---|---|
| author | Maximilian Niyazi Marco-Domenico Caversaccio Patrick Dubach Andreas Geretschläger Andreas Arnold Claus Belka Daniel M. Aebersold Norbert M. Blumstein |
| author_facet | Maximilian Niyazi Marco-Domenico Caversaccio Patrick Dubach Andreas Geretschläger Andreas Arnold Claus Belka Daniel M. Aebersold Norbert M. Blumstein |
| author_sort | Maximilian Niyazi |
| collection | DOAJ |
| description | We present a case of a Rendu-Osler-Weber disease patient with recurrent life threatening epistaxis demanding multiple blood transfusions despite of repetitive endoscopic laser and electrocoagulations, endovascular embolisation, septodermoplasty, and long-term intranasal dressings. As alternative treatment modalities repeatedly failed and the patient became almost permanently dependent on nasal dressing, we performed a highly conformal intensity-modulated radiotherapy of the nasal cavity; a total dose of 50 Gy in 2 Gy single fractions was applied. The therapy was very well tolerated, no acute toxicities occurred. Two weeks after the last radiation dose had been applied, the nasal dressing could be removed without problems. Endoscopical control revealed an almost avascular white mucosa without any trace of bleeding spots; previously existing hemangiomas and crusts had disappeared. After a 1-year-follow up, the patient had no significant recurrent epistaxis. |
| format | Article |
| id | doaj-art-c6527a1f4a5e42d78d7e564c350a68d2 |
| institution | Kabale University |
| issn | 1687-9627 1687-9635 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Medicine |
| spelling | doaj-art-c6527a1f4a5e42d78d7e564c350a68d22025-02-03T01:13:07ZengWileyCase Reports in Medicine1687-96271687-96352010-01-01201010.1155/2010/321835321835Intensity-Modulated Radiotherapy for a Rendu-Osler-Weber Disease Patient with Recurrent Severe Epistaxis: A Case ReportMaximilian Niyazi0Marco-Domenico Caversaccio1Patrick Dubach2Andreas Geretschläger3Andreas Arnold4Claus Belka5Daniel M. Aebersold6Norbert M. Blumstein7Department of Radiation Oncology, Ludwig-Maximilians-University München, Marchioninistr. 15, 81377 München, GermanyDepartment of Otolaryngology, Head and Neck Surgery, Inselspital, Bern University Hospital, University of Bern, CH-3010 Bern, SwitzerlandDepartment of Otolaryngology, Head and Neck Surgery, Inselspital, Bern University Hospital, University of Bern, CH-3010 Bern, SwitzerlandDepartment of Radiation Oncology, Inselspital, Bern University Hospital, University of Bern, CH-3010 Bern, SwitzerlandDepartment of Otolaryngology, Head and Neck Surgery, Inselspital, Bern University Hospital, University of Bern, CH-3010 Bern, SwitzerlandDepartment of Radiation Oncology, Ludwig-Maximilians-University München, Marchioninistr. 15, 81377 München, GermanyDepartment of Radiation Oncology, Inselspital, Bern University Hospital, University of Bern, CH-3010 Bern, SwitzerlandDepartment of Radiation Oncology, Inselspital, Bern University Hospital, University of Bern, CH-3010 Bern, SwitzerlandWe present a case of a Rendu-Osler-Weber disease patient with recurrent life threatening epistaxis demanding multiple blood transfusions despite of repetitive endoscopic laser and electrocoagulations, endovascular embolisation, septodermoplasty, and long-term intranasal dressings. As alternative treatment modalities repeatedly failed and the patient became almost permanently dependent on nasal dressing, we performed a highly conformal intensity-modulated radiotherapy of the nasal cavity; a total dose of 50 Gy in 2 Gy single fractions was applied. The therapy was very well tolerated, no acute toxicities occurred. Two weeks after the last radiation dose had been applied, the nasal dressing could be removed without problems. Endoscopical control revealed an almost avascular white mucosa without any trace of bleeding spots; previously existing hemangiomas and crusts had disappeared. After a 1-year-follow up, the patient had no significant recurrent epistaxis.http://dx.doi.org/10.1155/2010/321835 |
| spellingShingle | Maximilian Niyazi Marco-Domenico Caversaccio Patrick Dubach Andreas Geretschläger Andreas Arnold Claus Belka Daniel M. Aebersold Norbert M. Blumstein Intensity-Modulated Radiotherapy for a Rendu-Osler-Weber Disease Patient with Recurrent Severe Epistaxis: A Case Report Case Reports in Medicine |
| title | Intensity-Modulated Radiotherapy for a Rendu-Osler-Weber Disease Patient with Recurrent Severe Epistaxis: A Case Report |
| title_full | Intensity-Modulated Radiotherapy for a Rendu-Osler-Weber Disease Patient with Recurrent Severe Epistaxis: A Case Report |
| title_fullStr | Intensity-Modulated Radiotherapy for a Rendu-Osler-Weber Disease Patient with Recurrent Severe Epistaxis: A Case Report |
| title_full_unstemmed | Intensity-Modulated Radiotherapy for a Rendu-Osler-Weber Disease Patient with Recurrent Severe Epistaxis: A Case Report |
| title_short | Intensity-Modulated Radiotherapy for a Rendu-Osler-Weber Disease Patient with Recurrent Severe Epistaxis: A Case Report |
| title_sort | intensity modulated radiotherapy for a rendu osler weber disease patient with recurrent severe epistaxis a case report |
| url | http://dx.doi.org/10.1155/2010/321835 |
| work_keys_str_mv | AT maximilianniyazi intensitymodulatedradiotherapyforarenduoslerweberdiseasepatientwithrecurrentsevereepistaxisacasereport AT marcodomenicocaversaccio intensitymodulatedradiotherapyforarenduoslerweberdiseasepatientwithrecurrentsevereepistaxisacasereport AT patrickdubach intensitymodulatedradiotherapyforarenduoslerweberdiseasepatientwithrecurrentsevereepistaxisacasereport AT andreasgeretschlager intensitymodulatedradiotherapyforarenduoslerweberdiseasepatientwithrecurrentsevereepistaxisacasereport AT andreasarnold intensitymodulatedradiotherapyforarenduoslerweberdiseasepatientwithrecurrentsevereepistaxisacasereport AT clausbelka intensitymodulatedradiotherapyforarenduoslerweberdiseasepatientwithrecurrentsevereepistaxisacasereport AT danielmaebersold intensitymodulatedradiotherapyforarenduoslerweberdiseasepatientwithrecurrentsevereepistaxisacasereport AT norbertmblumstein intensitymodulatedradiotherapyforarenduoslerweberdiseasepatientwithrecurrentsevereepistaxisacasereport |