Role of high-dose chemotherapy with hemopoietic stem cell transplantation in the treatment of multiple myeloma
Treatment results in a group of patients with multiple myeloma (n=18) treated with melfalan (200 mg/m2) followed by autologous peripheral blood stem cell transplantation as a second-line therapy are presented. Thirteen patients received one course of high-dose chemotherapy (HDCT), 5 had 2 courses. B...
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| Format: | Article |
| Language: | Russian |
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ABV-press
2022-11-01
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| Series: | Онкогематология |
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| Online Access: | https://oncohematology.abvpress.ru/ongm/article/view/746 |
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| author | S. V. Minenko A. Yu. Popov N. V. Zhukov O. M. Votyakova V. V. Ptushkin |
| author_facet | S. V. Minenko A. Yu. Popov N. V. Zhukov O. M. Votyakova V. V. Ptushkin |
| author_sort | S. V. Minenko |
| collection | DOAJ |
| description | Treatment results in a group of patients with multiple myeloma (n=18) treated with melfalan (200 mg/m2) followed by autologous peripheral blood stem cell transplantation as a second-line therapy are presented. Thirteen patients received one course of high-dose chemotherapy (HDCT), 5 had 2 courses. Before HDCT all treated patients achieved a partial remission (15 patients after 3 courses VAD, 3 patients after 3 courses of VAD and 2 courses of velcade- doxorubicin- prednisolone). The median time to disease progression was 33.1 (range 26—40) months; that of overall survival was 55.4 (range 29— 40) months. |
| format | Article |
| id | doaj-art-c64ef0ba59af417a864c050ffaaa530e |
| institution | DOAJ |
| issn | 1818-8346 2413-4023 |
| language | Russian |
| publishDate | 2022-11-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Онкогематология |
| spelling | doaj-art-c64ef0ba59af417a864c050ffaaa530e2025-08-20T03:21:28ZrusABV-pressОнкогематология1818-83462413-40232022-11-0104111610.17650/1818-8346-2008-0-4-11-16624Role of high-dose chemotherapy with hemopoietic stem cell transplantation in the treatment of multiple myelomaS. V. Minenko0A. Yu. Popov1N. V. Zhukov2O. M. Votyakova3V. V. Ptushkin4Federal Research Centre of Pediatric Hematology, Oncology and ImmunologyFederal Research Centre of Pediatric Hematology, Oncology and ImmunologyFederal Research Centre of Pediatric Hematology, Oncology and ImmunologyN.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical SciencesFederal Research Centre of Pediatric Hematology, Oncology and ImmunologyTreatment results in a group of patients with multiple myeloma (n=18) treated with melfalan (200 mg/m2) followed by autologous peripheral blood stem cell transplantation as a second-line therapy are presented. Thirteen patients received one course of high-dose chemotherapy (HDCT), 5 had 2 courses. Before HDCT all treated patients achieved a partial remission (15 patients after 3 courses VAD, 3 patients after 3 courses of VAD and 2 courses of velcade- doxorubicin- prednisolone). The median time to disease progression was 33.1 (range 26—40) months; that of overall survival was 55.4 (range 29— 40) months.https://oncohematology.abvpress.ru/ongm/article/view/746multiple myelomahigh-dose chemotherapyautologous peripheral blood stem cell transplantation |
| spellingShingle | S. V. Minenko A. Yu. Popov N. V. Zhukov O. M. Votyakova V. V. Ptushkin Role of high-dose chemotherapy with hemopoietic stem cell transplantation in the treatment of multiple myeloma Онкогематология multiple myeloma high-dose chemotherapy autologous peripheral blood stem cell transplantation |
| title | Role of high-dose chemotherapy with hemopoietic stem cell transplantation in the treatment of multiple myeloma |
| title_full | Role of high-dose chemotherapy with hemopoietic stem cell transplantation in the treatment of multiple myeloma |
| title_fullStr | Role of high-dose chemotherapy with hemopoietic stem cell transplantation in the treatment of multiple myeloma |
| title_full_unstemmed | Role of high-dose chemotherapy with hemopoietic stem cell transplantation in the treatment of multiple myeloma |
| title_short | Role of high-dose chemotherapy with hemopoietic stem cell transplantation in the treatment of multiple myeloma |
| title_sort | role of high dose chemotherapy with hemopoietic stem cell transplantation in the treatment of multiple myeloma |
| topic | multiple myeloma high-dose chemotherapy autologous peripheral blood stem cell transplantation |
| url | https://oncohematology.abvpress.ru/ongm/article/view/746 |
| work_keys_str_mv | AT svminenko roleofhighdosechemotherapywithhemopoieticstemcelltransplantationinthetreatmentofmultiplemyeloma AT ayupopov roleofhighdosechemotherapywithhemopoieticstemcelltransplantationinthetreatmentofmultiplemyeloma AT nvzhukov roleofhighdosechemotherapywithhemopoieticstemcelltransplantationinthetreatmentofmultiplemyeloma AT omvotyakova roleofhighdosechemotherapywithhemopoieticstemcelltransplantationinthetreatmentofmultiplemyeloma AT vvptushkin roleofhighdosechemotherapywithhemopoieticstemcelltransplantationinthetreatmentofmultiplemyeloma |