Myeloid Neoplasms in the Guise of Nutritional Deficiency
The classic BCR-ABL-negative myeloproliferative neoplasms (MPNs) which include polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF) are among the most frequent hematologic neoplasms. Because of their relatively smooth clinical course, it is likely that many of thes...
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Wiley
2012-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2012/826939 |
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| author | Veda Parthasarathy |
| author_facet | Veda Parthasarathy |
| author_sort | Veda Parthasarathy |
| collection | DOAJ |
| description | The classic BCR-ABL-negative myeloproliferative neoplasms (MPNs) which include polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF) are among the most frequent hematologic neoplasms. Because of their relatively smooth clinical course, it is likely that many of these MPNs actually go undetected. Considering the high prevalence of iron, folic-acid, and vitamin B12 deficiencies in developing countries, their coexistence with MPN can be expected frequently. In such situations where both disorders coexist, MPN is often overlooked. This causes considerable diagnostic delay. In this paper, two cases of PMF and one case of PV where the diagnosis of MPN was delayed for about 3 years are discussed. Presence of concomitant vitamin B12, folate, and iron deficiencies perhaps camouflaged the underlying MPN. Bearing in mind the possibility of MPN, even in the setting of apparent nutritional deficiency and performing a bone marrow evaluation, is the crucial step in unveiling the hidden MPN. |
| format | Article |
| id | doaj-art-c64bf1fa1147483a9db6fcde68514563 |
| institution | OA Journals |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-c64bf1fa1147483a9db6fcde685145632025-08-20T02:19:15ZengWileyCase Reports in Hematology2090-65602090-65792012-01-01201210.1155/2012/826939826939Myeloid Neoplasms in the Guise of Nutritional DeficiencyVeda Parthasarathy0Department of Pathology, ESI-PGIMSR, 10 Sri Devi Krupa, 1st Main, 1st Block, RT Nagar, Bangalore 560032, IndiaThe classic BCR-ABL-negative myeloproliferative neoplasms (MPNs) which include polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF) are among the most frequent hematologic neoplasms. Because of their relatively smooth clinical course, it is likely that many of these MPNs actually go undetected. Considering the high prevalence of iron, folic-acid, and vitamin B12 deficiencies in developing countries, their coexistence with MPN can be expected frequently. In such situations where both disorders coexist, MPN is often overlooked. This causes considerable diagnostic delay. In this paper, two cases of PMF and one case of PV where the diagnosis of MPN was delayed for about 3 years are discussed. Presence of concomitant vitamin B12, folate, and iron deficiencies perhaps camouflaged the underlying MPN. Bearing in mind the possibility of MPN, even in the setting of apparent nutritional deficiency and performing a bone marrow evaluation, is the crucial step in unveiling the hidden MPN.http://dx.doi.org/10.1155/2012/826939 |
| spellingShingle | Veda Parthasarathy Myeloid Neoplasms in the Guise of Nutritional Deficiency Case Reports in Hematology |
| title | Myeloid Neoplasms in the Guise of Nutritional Deficiency |
| title_full | Myeloid Neoplasms in the Guise of Nutritional Deficiency |
| title_fullStr | Myeloid Neoplasms in the Guise of Nutritional Deficiency |
| title_full_unstemmed | Myeloid Neoplasms in the Guise of Nutritional Deficiency |
| title_short | Myeloid Neoplasms in the Guise of Nutritional Deficiency |
| title_sort | myeloid neoplasms in the guise of nutritional deficiency |
| url | http://dx.doi.org/10.1155/2012/826939 |
| work_keys_str_mv | AT vedaparthasarathy myeloidneoplasmsintheguiseofnutritionaldeficiency |