Pemphigoid Gestationis after Spontaneous Expulsion of a Massive Complete Hydatidiform Mole
Pemphigoid gestationis (PG) is a rare, perinatal, autoimmune, and blistering dermatosis. Only few cases of PG involving hydatidiform moles have been reported. Complete hydatidiform moles are usually evacuated by dilatation and curettage. We report a patient with a massive complete hydatidiform mole...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Case Reports in Obstetrics and Gynecology |
| Online Access: | http://dx.doi.org/10.1155/2013/267268 |
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| author | Naoki Matsumoto Marie Osada Kou Kaneko Ken Ohara Daito Noguchi Haruhiko Udagawa Nagazumi Suzuki Chieko Matsumoto Sachio Takahashi |
| author_facet | Naoki Matsumoto Marie Osada Kou Kaneko Ken Ohara Daito Noguchi Haruhiko Udagawa Nagazumi Suzuki Chieko Matsumoto Sachio Takahashi |
| author_sort | Naoki Matsumoto |
| collection | DOAJ |
| description | Pemphigoid gestationis (PG) is a rare, perinatal, autoimmune, and blistering dermatosis. Only few cases of PG involving hydatidiform moles have been reported. Complete hydatidiform moles are usually evacuated by dilatation and curettage. We report a patient with a massive complete hydatidiform mole that underwent spontaneous expulsion; she subsequently developed PG. A 19-year-old unmarried nulligravid woman was referred to our hospital following excessive vaginal bleeding after an uncertain amenorrheal period. The patient presented with preshock vital signs, severe anemia, and a positive urine pregnancy test. Imaging examinations revealed a massive intrauterine mass (19 × 15 × 10 cm), suggesting a complete hydatidiform mole. She was hospitalized and treated with blood transfusion. Sixteen hours after hospitalization, the massive molar mass underwent spontaneous expulsion and bleeding ceased. Three days after the expulsion, she developed pruritic skin lesions including papules, erythemas, and bullae, which spread over her entire body. Skin biopsy revealed PG and subepidermal blister formation and linear complement C3 deposition along the basement membrane zone, and the serum anti-BP180 antibody level was found to be high on measurement. She was effectively treated with 50 mg/day of oral prednisolone. Her skin lesions disappeared, leaving pigmentation. |
| format | Article |
| id | doaj-art-c64be2deac8d4abca4802206ed7424b7 |
| institution | DOAJ |
| issn | 2090-6684 2090-6692 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Obstetrics and Gynecology |
| spelling | doaj-art-c64be2deac8d4abca4802206ed7424b72025-08-20T03:23:22ZengWileyCase Reports in Obstetrics and Gynecology2090-66842090-66922013-01-01201310.1155/2013/267268267268Pemphigoid Gestationis after Spontaneous Expulsion of a Massive Complete Hydatidiform MoleNaoki Matsumoto0Marie Osada1Kou Kaneko2Ken Ohara3Daito Noguchi4Haruhiko Udagawa5Nagazumi Suzuki6Chieko Matsumoto7Sachio Takahashi8Department of Obstetrics and Gynecology, Fukaya Red Cross Hospital, 5-8-1 Kamishibachonishi, Fukaya City, Saitama 366-0052, JapanDepartment of Obstetrics and Gynecology, Fukaya Red Cross Hospital, 5-8-1 Kamishibachonishi, Fukaya City, Saitama 366-0052, JapanDepartment of Pathology, Fukaya Red Cross Hospital, 5-8-1 Kamishibachonishi, Fukaya City, Saitama 366-0052, JapanDepartment of Obstetrics and Gynecology, Saitama Medical Center, Saitama Medical University, 1981 Kamoda, Kawagoe City, Saitama 350-8550, JapanDepartment of Obstetrics and Gynecology, Fukaya Red Cross Hospital, 5-8-1 Kamishibachonishi, Fukaya City, Saitama 366-0052, JapanDepartment of Obstetrics and Gynecology, Fukaya Red Cross Hospital, 5-8-1 Kamishibachonishi, Fukaya City, Saitama 366-0052, JapanDepartment of Obstetrics and Gynecology, Fukaya Red Cross Hospital, 5-8-1 Kamishibachonishi, Fukaya City, Saitama 366-0052, JapanDepartment of Obstetrics and Gynecology, Fukaya Red Cross Hospital, 5-8-1 Kamishibachonishi, Fukaya City, Saitama 366-0052, JapanDepartment of Obstetrics and Gynecology, Fukaya Red Cross Hospital, 5-8-1 Kamishibachonishi, Fukaya City, Saitama 366-0052, JapanPemphigoid gestationis (PG) is a rare, perinatal, autoimmune, and blistering dermatosis. Only few cases of PG involving hydatidiform moles have been reported. Complete hydatidiform moles are usually evacuated by dilatation and curettage. We report a patient with a massive complete hydatidiform mole that underwent spontaneous expulsion; she subsequently developed PG. A 19-year-old unmarried nulligravid woman was referred to our hospital following excessive vaginal bleeding after an uncertain amenorrheal period. The patient presented with preshock vital signs, severe anemia, and a positive urine pregnancy test. Imaging examinations revealed a massive intrauterine mass (19 × 15 × 10 cm), suggesting a complete hydatidiform mole. She was hospitalized and treated with blood transfusion. Sixteen hours after hospitalization, the massive molar mass underwent spontaneous expulsion and bleeding ceased. Three days after the expulsion, she developed pruritic skin lesions including papules, erythemas, and bullae, which spread over her entire body. Skin biopsy revealed PG and subepidermal blister formation and linear complement C3 deposition along the basement membrane zone, and the serum anti-BP180 antibody level was found to be high on measurement. She was effectively treated with 50 mg/day of oral prednisolone. Her skin lesions disappeared, leaving pigmentation.http://dx.doi.org/10.1155/2013/267268 |
| spellingShingle | Naoki Matsumoto Marie Osada Kou Kaneko Ken Ohara Daito Noguchi Haruhiko Udagawa Nagazumi Suzuki Chieko Matsumoto Sachio Takahashi Pemphigoid Gestationis after Spontaneous Expulsion of a Massive Complete Hydatidiform Mole Case Reports in Obstetrics and Gynecology |
| title | Pemphigoid Gestationis after Spontaneous Expulsion of a Massive Complete Hydatidiform Mole |
| title_full | Pemphigoid Gestationis after Spontaneous Expulsion of a Massive Complete Hydatidiform Mole |
| title_fullStr | Pemphigoid Gestationis after Spontaneous Expulsion of a Massive Complete Hydatidiform Mole |
| title_full_unstemmed | Pemphigoid Gestationis after Spontaneous Expulsion of a Massive Complete Hydatidiform Mole |
| title_short | Pemphigoid Gestationis after Spontaneous Expulsion of a Massive Complete Hydatidiform Mole |
| title_sort | pemphigoid gestationis after spontaneous expulsion of a massive complete hydatidiform mole |
| url | http://dx.doi.org/10.1155/2013/267268 |
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