The role of tRNA-Derived small RNAs (tsRNAs) in pancreatic cancer and acute pancreatitis
tRNA-derived small RNAs (tsRNAs), encompassing tRNA fragments (tRFs) and tRNA-derived stress-induced RNAs (tiRNAs), represent a category of non-coding small RNAs (sncRNAs) that are increasingly recognized for their diverse biological functions. These functions include gene silencing, ribosome biogen...
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KeAi Communications Co., Ltd.
2025-04-01
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| Series: | Non-coding RNA Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2468054024001756 |
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| author | Yan Pan Xiaowei Ying Xueting Zhang Hongting Jiang Junjie Yan Shiwei Duan |
| author_facet | Yan Pan Xiaowei Ying Xueting Zhang Hongting Jiang Junjie Yan Shiwei Duan |
| author_sort | Yan Pan |
| collection | DOAJ |
| description | tRNA-derived small RNAs (tsRNAs), encompassing tRNA fragments (tRFs) and tRNA-derived stress-induced RNAs (tiRNAs), represent a category of non-coding small RNAs (sncRNAs) that are increasingly recognized for their diverse biological functions. These functions include gene silencing, ribosome biogenesis, retrotransposition, and epigenetics. tsRNAs have been identified as key players in the progression of various tumors, yet their specific roles in pancreatic cancer (PC) and acute pancreatitis (AP) remain largely unexplored. Pancreatic cancer, particularly pancreatic ductal adenocarcinoma, is notorious for its high mortality rate and extremely low patient survival rate, primarily due to challenges in early diagnosis. Similarly, acute pancreatitis is a complex and significant disease. This article reviews the roles of 18 tsRNAs in PC and AP, focusing on their mechanisms of action and potential clinical applications in these two diseases. These tsRNAs influence the progression of pancreatic cancer and acute pancreatitis by modulating various pathways, including ZBP1/NLRP3, Hippo, PI3K/AKT, glycolysis/gluconeogenesis, and Wnt signaling. Notably, the dysregulation of tsRNAs is closely linked to critical clinical factors in pancreatic cancer and acute pancreatitis, such as lymph node metastasis, tumor-node-metastasis (TNM) stage, overall survival (OS), and disease-free survival (DFS). This article not only elucidates the mechanisms by which tsRNAs affect pancreatic cancer and acute pancreatitis but also explores their potential as biomarkers and therapeutic targets for pancreatic cancer. The insights provided here offer valuable references for future research, highlighting the importance of tsRNAs in the diagnosis and treatment of these challenging diseases. |
| format | Article |
| id | doaj-art-c649def9d8cb4d51a2411022d00efb39 |
| institution | DOAJ |
| issn | 2468-0540 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Non-coding RNA Research |
| spelling | doaj-art-c649def9d8cb4d51a2411022d00efb392025-08-20T02:55:32ZengKeAi Communications Co., Ltd.Non-coding RNA Research2468-05402025-04-011120020810.1016/j.ncrna.2024.12.011The role of tRNA-Derived small RNAs (tsRNAs) in pancreatic cancer and acute pancreatitisYan Pan0Xiaowei Ying1Xueting Zhang2Hongting Jiang3Junjie Yan4Shiwei Duan5Department of Integrative Oncology, The First People's Hospital of Fuyang, Fuyang First Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, China; Corresponding author.Department of Clinical Medicine, School of Medicine, Hangzhou City University, Hangzhou, Zhejiang, ChinaDepartment of Clinical Medicine, School of Medicine, Hangzhou City University, Hangzhou, Zhejiang, ChinaDepartment of Clinical Medicine, School of Medicine, Hangzhou City University, Hangzhou, Zhejiang, ChinaDepartment of Clinical Medicine, School of Medicine, Hangzhou City University, Hangzhou, Zhejiang, ChinaDepartment of Clinical Medicine, School of Medicine, Hangzhou City University, Hangzhou, Zhejiang, China; Corresponding author.tRNA-derived small RNAs (tsRNAs), encompassing tRNA fragments (tRFs) and tRNA-derived stress-induced RNAs (tiRNAs), represent a category of non-coding small RNAs (sncRNAs) that are increasingly recognized for their diverse biological functions. These functions include gene silencing, ribosome biogenesis, retrotransposition, and epigenetics. tsRNAs have been identified as key players in the progression of various tumors, yet their specific roles in pancreatic cancer (PC) and acute pancreatitis (AP) remain largely unexplored. Pancreatic cancer, particularly pancreatic ductal adenocarcinoma, is notorious for its high mortality rate and extremely low patient survival rate, primarily due to challenges in early diagnosis. Similarly, acute pancreatitis is a complex and significant disease. This article reviews the roles of 18 tsRNAs in PC and AP, focusing on their mechanisms of action and potential clinical applications in these two diseases. These tsRNAs influence the progression of pancreatic cancer and acute pancreatitis by modulating various pathways, including ZBP1/NLRP3, Hippo, PI3K/AKT, glycolysis/gluconeogenesis, and Wnt signaling. Notably, the dysregulation of tsRNAs is closely linked to critical clinical factors in pancreatic cancer and acute pancreatitis, such as lymph node metastasis, tumor-node-metastasis (TNM) stage, overall survival (OS), and disease-free survival (DFS). This article not only elucidates the mechanisms by which tsRNAs affect pancreatic cancer and acute pancreatitis but also explores their potential as biomarkers and therapeutic targets for pancreatic cancer. The insights provided here offer valuable references for future research, highlighting the importance of tsRNAs in the diagnosis and treatment of these challenging diseases.http://www.sciencedirect.com/science/article/pii/S2468054024001756tsRNAsPancreatic cancerAcute pancreatitisGene regulationBiomarkers |
| spellingShingle | Yan Pan Xiaowei Ying Xueting Zhang Hongting Jiang Junjie Yan Shiwei Duan The role of tRNA-Derived small RNAs (tsRNAs) in pancreatic cancer and acute pancreatitis Non-coding RNA Research tsRNAs Pancreatic cancer Acute pancreatitis Gene regulation Biomarkers |
| title | The role of tRNA-Derived small RNAs (tsRNAs) in pancreatic cancer and acute pancreatitis |
| title_full | The role of tRNA-Derived small RNAs (tsRNAs) in pancreatic cancer and acute pancreatitis |
| title_fullStr | The role of tRNA-Derived small RNAs (tsRNAs) in pancreatic cancer and acute pancreatitis |
| title_full_unstemmed | The role of tRNA-Derived small RNAs (tsRNAs) in pancreatic cancer and acute pancreatitis |
| title_short | The role of tRNA-Derived small RNAs (tsRNAs) in pancreatic cancer and acute pancreatitis |
| title_sort | role of trna derived small rnas tsrnas in pancreatic cancer and acute pancreatitis |
| topic | tsRNAs Pancreatic cancer Acute pancreatitis Gene regulation Biomarkers |
| url | http://www.sciencedirect.com/science/article/pii/S2468054024001756 |
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