G-quadruplex forming sequences in the genome of all known human viruses: A comprehensive guide.
G-quadruplexes are non-canonical nucleic-acid structures that control transcription, replication, and recombination in organisms. G-quadruplexes are present in eukaryotes, prokaryotes, and viruses. In the latter, mounting evidence indicates their key biological activity. Since data on viruses are sc...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2018-12-01
|
| Series: | PLoS Computational Biology |
| Online Access: | https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1006675&type=printable |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849702131249971200 |
|---|---|
| author | Enrico Lavezzo Michele Berselli Ilaria Frasson Rosalba Perrone Giorgio Palù Alessandra R Brazzale Sara N Richter Stefano Toppo |
| author_facet | Enrico Lavezzo Michele Berselli Ilaria Frasson Rosalba Perrone Giorgio Palù Alessandra R Brazzale Sara N Richter Stefano Toppo |
| author_sort | Enrico Lavezzo |
| collection | DOAJ |
| description | G-quadruplexes are non-canonical nucleic-acid structures that control transcription, replication, and recombination in organisms. G-quadruplexes are present in eukaryotes, prokaryotes, and viruses. In the latter, mounting evidence indicates their key biological activity. Since data on viruses are scattered, we here present a comprehensive analysis of potential quadruplex-forming sequences (PQS) in the genome of all known viruses that can infect humans. We show that occurrence and location of PQSs are features characteristic of each virus class and family. Our statistical analysis proves that their presence within the viral genome is orderly arranged, as indicated by the possibility to correctly assign up to two-thirds of viruses to their exact class based on the PQS classification. For each virus we provide: i) the list of all PQS present in the genome (positive and negative strands), ii) their position in the viral genome, iii) the degree of conservation among strains of each PQS in its genome context, iv) the statistical significance of PQS abundance. This information is accessible from a database to allow the easy navigation of the results: http://www.medcomp.medicina.unipd.it/main_site/doku.php?id=g4virus. The availability of these data will greatly expedite research on G-quadruplex in viruses, with the possibility to accelerate finding therapeutic opportunities to numerous and some fearsome human diseases. |
| format | Article |
| id | doaj-art-c648b46eb4964041aafca1d8e2d27290 |
| institution | DOAJ |
| issn | 1553-734X 1553-7358 |
| language | English |
| publishDate | 2018-12-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Computational Biology |
| spelling | doaj-art-c648b46eb4964041aafca1d8e2d272902025-08-20T03:17:44ZengPublic Library of Science (PLoS)PLoS Computational Biology1553-734X1553-73582018-12-011412e100667510.1371/journal.pcbi.1006675G-quadruplex forming sequences in the genome of all known human viruses: A comprehensive guide.Enrico LavezzoMichele BerselliIlaria FrassonRosalba PerroneGiorgio PalùAlessandra R BrazzaleSara N RichterStefano ToppoG-quadruplexes are non-canonical nucleic-acid structures that control transcription, replication, and recombination in organisms. G-quadruplexes are present in eukaryotes, prokaryotes, and viruses. In the latter, mounting evidence indicates their key biological activity. Since data on viruses are scattered, we here present a comprehensive analysis of potential quadruplex-forming sequences (PQS) in the genome of all known viruses that can infect humans. We show that occurrence and location of PQSs are features characteristic of each virus class and family. Our statistical analysis proves that their presence within the viral genome is orderly arranged, as indicated by the possibility to correctly assign up to two-thirds of viruses to their exact class based on the PQS classification. For each virus we provide: i) the list of all PQS present in the genome (positive and negative strands), ii) their position in the viral genome, iii) the degree of conservation among strains of each PQS in its genome context, iv) the statistical significance of PQS abundance. This information is accessible from a database to allow the easy navigation of the results: http://www.medcomp.medicina.unipd.it/main_site/doku.php?id=g4virus. The availability of these data will greatly expedite research on G-quadruplex in viruses, with the possibility to accelerate finding therapeutic opportunities to numerous and some fearsome human diseases.https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1006675&type=printable |
| spellingShingle | Enrico Lavezzo Michele Berselli Ilaria Frasson Rosalba Perrone Giorgio Palù Alessandra R Brazzale Sara N Richter Stefano Toppo G-quadruplex forming sequences in the genome of all known human viruses: A comprehensive guide. PLoS Computational Biology |
| title | G-quadruplex forming sequences in the genome of all known human viruses: A comprehensive guide. |
| title_full | G-quadruplex forming sequences in the genome of all known human viruses: A comprehensive guide. |
| title_fullStr | G-quadruplex forming sequences in the genome of all known human viruses: A comprehensive guide. |
| title_full_unstemmed | G-quadruplex forming sequences in the genome of all known human viruses: A comprehensive guide. |
| title_short | G-quadruplex forming sequences in the genome of all known human viruses: A comprehensive guide. |
| title_sort | g quadruplex forming sequences in the genome of all known human viruses a comprehensive guide |
| url | https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1006675&type=printable |
| work_keys_str_mv | AT enricolavezzo gquadruplexformingsequencesinthegenomeofallknownhumanvirusesacomprehensiveguide AT micheleberselli gquadruplexformingsequencesinthegenomeofallknownhumanvirusesacomprehensiveguide AT ilariafrasson gquadruplexformingsequencesinthegenomeofallknownhumanvirusesacomprehensiveguide AT rosalbaperrone gquadruplexformingsequencesinthegenomeofallknownhumanvirusesacomprehensiveguide AT giorgiopalu gquadruplexformingsequencesinthegenomeofallknownhumanvirusesacomprehensiveguide AT alessandrarbrazzale gquadruplexformingsequencesinthegenomeofallknownhumanvirusesacomprehensiveguide AT saranrichter gquadruplexformingsequencesinthegenomeofallknownhumanvirusesacomprehensiveguide AT stefanotoppo gquadruplexformingsequencesinthegenomeofallknownhumanvirusesacomprehensiveguide |