mRNA-Based Biomarker Identification for Targeted Therapy Development in Pancreatic Cancer
Pancreatic cancer is one of the highly malignant cancers that have poor prognosis and limited treatment options. The development of targeted therapies is important for improving patient outcomes. In this study, we analyzed the datasets from the GEO database to identify potential mRNA biomarkers for...
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MDPI AG
2025-03-01
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| Series: | Biology and Life Sciences Forum |
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| Online Access: | https://www.mdpi.com/2673-9976/43/1/2 |
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| author | Saima Firdaus Rafat Parveen |
| author_facet | Saima Firdaus Rafat Parveen |
| author_sort | Saima Firdaus |
| collection | DOAJ |
| description | Pancreatic cancer is one of the highly malignant cancers that have poor prognosis and limited treatment options. The development of targeted therapies is important for improving patient outcomes. In this study, we analyzed the datasets from the GEO database to identify potential mRNA biomarkers for pancreatic cancer. Differentially expressed gene (DEG) analysis was performed in R to identify genes that expressed differentially between tumor and normal samples. TFF1 and LAMC2 emerged as key candidate genes for pancreatic cancer among the identified DEGs. Additionally drugs approved by the FDA were repurposed as an inhibitor against key genes. These findings suggest that these genes play a significant role in pancreatic cancer progression and have the potential to serve as molecular elements for targeted therapies. |
| format | Article |
| id | doaj-art-c6462c8e36f5497e89eaacbbe99e2e3f |
| institution | OA Journals |
| issn | 2673-9976 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biology and Life Sciences Forum |
| spelling | doaj-art-c6462c8e36f5497e89eaacbbe99e2e3f2025-08-20T02:24:42ZengMDPI AGBiology and Life Sciences Forum2673-99762025-03-01431210.3390/blsf2025043002mRNA-Based Biomarker Identification for Targeted Therapy Development in Pancreatic CancerSaima Firdaus0Rafat Parveen1Department of Computer Science, Jamia Millia Islamia, New Delhi 110025, IndiaDepartment of Computer Science, Jamia Millia Islamia, New Delhi 110025, IndiaPancreatic cancer is one of the highly malignant cancers that have poor prognosis and limited treatment options. The development of targeted therapies is important for improving patient outcomes. In this study, we analyzed the datasets from the GEO database to identify potential mRNA biomarkers for pancreatic cancer. Differentially expressed gene (DEG) analysis was performed in R to identify genes that expressed differentially between tumor and normal samples. TFF1 and LAMC2 emerged as key candidate genes for pancreatic cancer among the identified DEGs. Additionally drugs approved by the FDA were repurposed as an inhibitor against key genes. These findings suggest that these genes play a significant role in pancreatic cancer progression and have the potential to serve as molecular elements for targeted therapies.https://www.mdpi.com/2673-9976/43/1/2pancreatic cancerbiomarkermRNA-based biomarkertarget therapypersonalized treatment |
| spellingShingle | Saima Firdaus Rafat Parveen mRNA-Based Biomarker Identification for Targeted Therapy Development in Pancreatic Cancer Biology and Life Sciences Forum pancreatic cancer biomarker mRNA-based biomarker target therapy personalized treatment |
| title | mRNA-Based Biomarker Identification for Targeted Therapy Development in Pancreatic Cancer |
| title_full | mRNA-Based Biomarker Identification for Targeted Therapy Development in Pancreatic Cancer |
| title_fullStr | mRNA-Based Biomarker Identification for Targeted Therapy Development in Pancreatic Cancer |
| title_full_unstemmed | mRNA-Based Biomarker Identification for Targeted Therapy Development in Pancreatic Cancer |
| title_short | mRNA-Based Biomarker Identification for Targeted Therapy Development in Pancreatic Cancer |
| title_sort | mrna based biomarker identification for targeted therapy development in pancreatic cancer |
| topic | pancreatic cancer biomarker mRNA-based biomarker target therapy personalized treatment |
| url | https://www.mdpi.com/2673-9976/43/1/2 |
| work_keys_str_mv | AT saimafirdaus mrnabasedbiomarkeridentificationfortargetedtherapydevelopmentinpancreaticcancer AT rafatparveen mrnabasedbiomarkeridentificationfortargetedtherapydevelopmentinpancreaticcancer |