Intelligent peptide‐based nanomaterials for targeted antibacterial therapy: Design, properties and applications
Abstract Bacterial infections pose a major threat to human health as well as livestock production. Traditional antibiotics face significant limitations in the complex in vivo environment, including toxic side effects, non‐specific accumulation, and poor pharmacokinetic profiles, posing considerable...
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| Format: | Article |
| Language: | English |
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Wiley
2025-08-01
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| Series: | Responsive Materials |
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| Online Access: | https://doi.org/10.1002/rpm.20240043 |
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| _version_ | 1849406587176747008 |
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| author | Chenlong Zhou Qi Tang Shuaikang Yang Guanghui Zhao Tao Wang Zhenduo Chen Yucheng Zhang Peng Tan Xi Ma |
| author_facet | Chenlong Zhou Qi Tang Shuaikang Yang Guanghui Zhao Tao Wang Zhenduo Chen Yucheng Zhang Peng Tan Xi Ma |
| author_sort | Chenlong Zhou |
| collection | DOAJ |
| description | Abstract Bacterial infections pose a major threat to human health as well as livestock production. Traditional antibiotics face significant limitations in the complex in vivo environment, including toxic side effects, non‐specific accumulation, and poor pharmacokinetic profiles, posing considerable challenges to effective antibacterial therapy. In this context, intelligent peptide‐based nanomaterials (IPBNs), which can specifically respond to pathological features or external stimuli to target the infection microenvironment are becoming emerging alternatives in the field of antibacterial therapy. However, a comprehensive summary of recent advances in IPBNs for antibacterial applications is still lacking. To this end, we first introduce the non‐covalent interactions that drive the stimuli‐responsive behavior of IPBNs. Subsequently, the response mechanisms and design strategies of IPBNs for different stimuli, including endogenous stimuli, exogenous stimuli, and multiple stimuli, are systematically discussed. In addition, a description of applications related to antimicrobial therapy is included. Finally, the biological properties, challenges, and future development trends of IPBNs are discussed. Overall, this review provides a comprehensive overview of IPBNs from the perspectives of design, mechanisms, properties and applications, aiming to promote more development work and explore their potential in fields such as biomedicine and animal husbandry. |
| format | Article |
| id | doaj-art-c64567c6f03b4c27a67c17eef25b8d64 |
| institution | Kabale University |
| issn | 2834-8966 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Responsive Materials |
| spelling | doaj-art-c64567c6f03b4c27a67c17eef25b8d642025-08-20T03:36:19ZengWileyResponsive Materials2834-89662025-08-0133n/an/a10.1002/rpm.20240043Intelligent peptide‐based nanomaterials for targeted antibacterial therapy: Design, properties and applicationsChenlong Zhou0Qi Tang1Shuaikang Yang2Guanghui Zhao3Tao Wang4Zhenduo Chen5Yucheng Zhang6Peng Tan7Xi Ma8State Key Laboratory of Animal Nutrition College of Animal Science and Technology China Agricultural University Beijing ChinaState Key Laboratory of Animal Nutrition College of Animal Science and Technology China Agricultural University Beijing ChinaSchool of Life Sciences Henan University Kaifeng ChinaState Key Laboratory of Animal Nutrition College of Animal Science and Technology China Agricultural University Beijing ChinaState Key Laboratory of Animal Nutrition College of Animal Science and Technology China Agricultural University Beijing ChinaCollege of Animal Science Fujian Agriculture and Forestry University Fuzhou ChinaState Key Laboratory of Animal Nutrition College of Animal Science and Technology China Agricultural University Beijing ChinaState Key Laboratory of Animal Nutrition College of Animal Science and Technology China Agricultural University Beijing ChinaState Key Laboratory of Animal Nutrition College of Animal Science and Technology China Agricultural University Beijing ChinaAbstract Bacterial infections pose a major threat to human health as well as livestock production. Traditional antibiotics face significant limitations in the complex in vivo environment, including toxic side effects, non‐specific accumulation, and poor pharmacokinetic profiles, posing considerable challenges to effective antibacterial therapy. In this context, intelligent peptide‐based nanomaterials (IPBNs), which can specifically respond to pathological features or external stimuli to target the infection microenvironment are becoming emerging alternatives in the field of antibacterial therapy. However, a comprehensive summary of recent advances in IPBNs for antibacterial applications is still lacking. To this end, we first introduce the non‐covalent interactions that drive the stimuli‐responsive behavior of IPBNs. Subsequently, the response mechanisms and design strategies of IPBNs for different stimuli, including endogenous stimuli, exogenous stimuli, and multiple stimuli, are systematically discussed. In addition, a description of applications related to antimicrobial therapy is included. Finally, the biological properties, challenges, and future development trends of IPBNs are discussed. Overall, this review provides a comprehensive overview of IPBNs from the perspectives of design, mechanisms, properties and applications, aiming to promote more development work and explore their potential in fields such as biomedicine and animal husbandry.https://doi.org/10.1002/rpm.20240043bacterial infectionmicroenvironmentself‐assemblystimuli‐responsivestructural transformation |
| spellingShingle | Chenlong Zhou Qi Tang Shuaikang Yang Guanghui Zhao Tao Wang Zhenduo Chen Yucheng Zhang Peng Tan Xi Ma Intelligent peptide‐based nanomaterials for targeted antibacterial therapy: Design, properties and applications Responsive Materials bacterial infection microenvironment self‐assembly stimuli‐responsive structural transformation |
| title | Intelligent peptide‐based nanomaterials for targeted antibacterial therapy: Design, properties and applications |
| title_full | Intelligent peptide‐based nanomaterials for targeted antibacterial therapy: Design, properties and applications |
| title_fullStr | Intelligent peptide‐based nanomaterials for targeted antibacterial therapy: Design, properties and applications |
| title_full_unstemmed | Intelligent peptide‐based nanomaterials for targeted antibacterial therapy: Design, properties and applications |
| title_short | Intelligent peptide‐based nanomaterials for targeted antibacterial therapy: Design, properties and applications |
| title_sort | intelligent peptide based nanomaterials for targeted antibacterial therapy design properties and applications |
| topic | bacterial infection microenvironment self‐assembly stimuli‐responsive structural transformation |
| url | https://doi.org/10.1002/rpm.20240043 |
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