Underestimated Incidence Rate of Pertussis in the Community: Results from Active Population-Based Surveillance in Yiwu, China
Background: The resurgence of pertussis in China underscores the urgency of active surveillance to complement the passive surveillance system. Methods: Active surveillance for pertussis was conducted from 1 June 2021 to 31 May 2022, at Yiwu, Zhejiang province of China. Patients with suspected pertus...
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2024-10-01
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| author | Hanying Dai Hanqing He Juan Xu Yao Zhu Tao Fu Bohan Chen Jie Li Yuan Gao Aiping Qin Maojun Zhang Zhujun Shao |
| author_facet | Hanying Dai Hanqing He Juan Xu Yao Zhu Tao Fu Bohan Chen Jie Li Yuan Gao Aiping Qin Maojun Zhang Zhujun Shao |
| author_sort | Hanying Dai |
| collection | DOAJ |
| description | Background: The resurgence of pertussis in China underscores the urgency of active surveillance to complement the passive surveillance system. Methods: Active surveillance for pertussis was conducted from 1 June 2021 to 31 May 2022, at Yiwu, Zhejiang province of China. Patients with suspected pertussis were further confirmed as pertussis cases by PCR and culture. The incidence rate of pertussis in the community was estimated. Results: The overall estimated incidence of pertussis was 108.3 per 100,000 (95% CrI: 91.7–126.4). Children aged 4–5 years had the highest incidence (1154.3 per 100,000 [95% CrI: 817.4–1553.5]), followed by infants aged 1 year (836.1 per 100,000 [95% CrI: 434.0–1308.8]). Infants aged 0–4 months had the highest hospitalization rate among the pertussis patients (>50.0%). Although the incidence was low in elderly aged ≥ 60 years, the hospitalization rate was rather high (6.7%). Conclusion: Active surveillance in this study revealed a higher burden of pertussis in Yiwu, China, compared to passive surveillance. Children aged 4–5 years are the dominant population group at risk of pertussis. Infants aged ≤ 4 months are the most vulnerable pertussis patients that require hospitalization treatment. Our results highlight the urgency of large-scale active surveillance of pertussis in China. |
| format | Article |
| id | doaj-art-c64524e04e50494fab952ccc43f3fd1a |
| institution | DOAJ |
| issn | 2076-2607 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | MDPI AG |
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| series | Microorganisms |
| spelling | doaj-art-c64524e04e50494fab952ccc43f3fd1a2025-08-20T02:48:06ZengMDPI AGMicroorganisms2076-26072024-10-011211218610.3390/microorganisms12112186Underestimated Incidence Rate of Pertussis in the Community: Results from Active Population-Based Surveillance in Yiwu, ChinaHanying Dai0Hanqing He1Juan Xu2Yao Zhu3Tao Fu4Bohan Chen5Jie Li6Yuan Gao7Aiping Qin8Maojun Zhang9Zhujun Shao10National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, ChinaZhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310000, ChinaNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, ChinaZhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310000, ChinaYiwu District Center for Disease Control and Prevention, Jinhua 321000, ChinaNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, ChinaNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, ChinaNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, ChinaNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, ChinaNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, ChinaNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, ChinaBackground: The resurgence of pertussis in China underscores the urgency of active surveillance to complement the passive surveillance system. Methods: Active surveillance for pertussis was conducted from 1 June 2021 to 31 May 2022, at Yiwu, Zhejiang province of China. Patients with suspected pertussis were further confirmed as pertussis cases by PCR and culture. The incidence rate of pertussis in the community was estimated. Results: The overall estimated incidence of pertussis was 108.3 per 100,000 (95% CrI: 91.7–126.4). Children aged 4–5 years had the highest incidence (1154.3 per 100,000 [95% CrI: 817.4–1553.5]), followed by infants aged 1 year (836.1 per 100,000 [95% CrI: 434.0–1308.8]). Infants aged 0–4 months had the highest hospitalization rate among the pertussis patients (>50.0%). Although the incidence was low in elderly aged ≥ 60 years, the hospitalization rate was rather high (6.7%). Conclusion: Active surveillance in this study revealed a higher burden of pertussis in Yiwu, China, compared to passive surveillance. Children aged 4–5 years are the dominant population group at risk of pertussis. Infants aged ≤ 4 months are the most vulnerable pertussis patients that require hospitalization treatment. Our results highlight the urgency of large-scale active surveillance of pertussis in China.https://www.mdpi.com/2076-2607/12/11/2186pertussisactive surveillanceincidencehospitalization rateChina |
| spellingShingle | Hanying Dai Hanqing He Juan Xu Yao Zhu Tao Fu Bohan Chen Jie Li Yuan Gao Aiping Qin Maojun Zhang Zhujun Shao Underestimated Incidence Rate of Pertussis in the Community: Results from Active Population-Based Surveillance in Yiwu, China Microorganisms pertussis active surveillance incidence hospitalization rate China |
| title | Underestimated Incidence Rate of Pertussis in the Community: Results from Active Population-Based Surveillance in Yiwu, China |
| title_full | Underestimated Incidence Rate of Pertussis in the Community: Results from Active Population-Based Surveillance in Yiwu, China |
| title_fullStr | Underestimated Incidence Rate of Pertussis in the Community: Results from Active Population-Based Surveillance in Yiwu, China |
| title_full_unstemmed | Underestimated Incidence Rate of Pertussis in the Community: Results from Active Population-Based Surveillance in Yiwu, China |
| title_short | Underestimated Incidence Rate of Pertussis in the Community: Results from Active Population-Based Surveillance in Yiwu, China |
| title_sort | underestimated incidence rate of pertussis in the community results from active population based surveillance in yiwu china |
| topic | pertussis active surveillance incidence hospitalization rate China |
| url | https://www.mdpi.com/2076-2607/12/11/2186 |
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