DON-Apt19S bioactive scaffold transplantation promotes in situ spinal cord repair in rats with transected spinal cord injury by effectively recruiting endogenous neural stem cells and mesenchymal stem cells

The spinal cord's limited regeneration is attributed to the scarcity of endogenous stem cells and a poor post-injury microenvironment in adult mammals. To overcome these challenges, we transplanted a DNA aptamer 19S (Apt19S) sustained-release decellularized optic nerve (DON) scaffold (DON-A) in...

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Bibliographic Details
Main Authors:	Bi-Qin Lai, Rong-Jie Wu, Chuang-Ran Wu, Hai-Yang Yu, Jing Xu, Shang-Bin Yang, Zheng-Hong Chen, Xing Li, Yi-Nan Guo, Yue Yang, Ming-Tian Che, Ting-Ting Wu, Guang-Tao Fu, Yu-Hui Yang, Zhen Chen, Nan Hua, Rui Liu, Qiu-Jian Zheng, Yuan-Feng Chen
Format:	Article
Language:	English
Published:	Elsevier 2025-06-01
Series:	Materials Today Bio
Subjects:	Spinal cord injury In situ repair Endogenous stem cells Neurogenesis Revascularization
Online Access:	http://www.sciencedirect.com/science/article/pii/S2590006425003138
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DON-Apt19S bioactive scaffold transplantation promotes in situ spinal cord repair in rats with transected spinal cord injury by effectively recruiting endogenous neural stem cells and mesenchymal stem cells

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