Vaccines for African swine fever: an update
African swine fever (ASF) is a fatal infectious disease of swine caused by the African swine fever virus (ASFV). Currently, the disease is listed as a legally notifiable disease that must be reported to the World Organization for Animal Health (WOAH). The economic losses to the global pig industry h...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-04-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2023.1139494/full |
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| author | Hongliang Zhang Saisai Zhao Saisai Zhao Haojie Zhang Zhihua Qin Hu Shan Xiulei Cai |
| author_facet | Hongliang Zhang Saisai Zhao Saisai Zhao Haojie Zhang Zhihua Qin Hu Shan Xiulei Cai |
| author_sort | Hongliang Zhang |
| collection | DOAJ |
| description | African swine fever (ASF) is a fatal infectious disease of swine caused by the African swine fever virus (ASFV). Currently, the disease is listed as a legally notifiable disease that must be reported to the World Organization for Animal Health (WOAH). The economic losses to the global pig industry have been insurmountable since the outbreak of ASF. Control and eradication of ASF are very critical during the current pandemic. Vaccination is the optimal strategy to prevent and control the ASF epidemic, but since inactivated ASFV vaccines have poor immune protection and there aren’t enough cell lines for efficient in vitro ASFV replication, an ASF vaccine with high immunoprotective potential still remains to be explored. Knowledge of the course of disease evolution, the way of virus transmission, and the breakthrough point of vaccine design will facilitate the development of an ASF vaccine. In this review, the paper aims to highlight the recent advances and breakthroughs in the epidemic and transmission of ASF, virus mutation, and the development of vaccines in recent years, focusing on future directions and trends. |
| format | Article |
| id | doaj-art-c642241ef7cd44a3af2eeee7df85b6a8 |
| institution | OA Journals |
| issn | 1664-302X |
| language | English |
| publishDate | 2023-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj-art-c642241ef7cd44a3af2eeee7df85b6a82025-08-20T02:30:49ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2023-04-011410.3389/fmicb.2023.11394941139494Vaccines for African swine fever: an updateHongliang Zhang0Saisai Zhao1Saisai Zhao2Haojie Zhang3Zhihua Qin4Hu Shan5Xiulei Cai6Shandong Collaborative Innovation Center for Development of Veterinary Pharmaceuticals, College of Veterinary Medicine, Qingdao Agricultural University, Qingdao, ChinaShandong Collaborative Innovation Center for Development of Veterinary Pharmaceuticals, College of Veterinary Medicine, Qingdao Agricultural University, Qingdao, ChinaCollege of Animal Science and Technology, Shandong Agricultural University, Tai’an, ChinaShandong Collaborative Innovation Center for Development of Veterinary Pharmaceuticals, College of Veterinary Medicine, Qingdao Agricultural University, Qingdao, ChinaShandong Collaborative Innovation Center for Development of Veterinary Pharmaceuticals, College of Veterinary Medicine, Qingdao Agricultural University, Qingdao, ChinaShandong Collaborative Innovation Center for Development of Veterinary Pharmaceuticals, College of Veterinary Medicine, Qingdao Agricultural University, Qingdao, ChinaShandong Collaborative Innovation Center for Development of Veterinary Pharmaceuticals, College of Veterinary Medicine, Qingdao Agricultural University, Qingdao, ChinaAfrican swine fever (ASF) is a fatal infectious disease of swine caused by the African swine fever virus (ASFV). Currently, the disease is listed as a legally notifiable disease that must be reported to the World Organization for Animal Health (WOAH). The economic losses to the global pig industry have been insurmountable since the outbreak of ASF. Control and eradication of ASF are very critical during the current pandemic. Vaccination is the optimal strategy to prevent and control the ASF epidemic, but since inactivated ASFV vaccines have poor immune protection and there aren’t enough cell lines for efficient in vitro ASFV replication, an ASF vaccine with high immunoprotective potential still remains to be explored. Knowledge of the course of disease evolution, the way of virus transmission, and the breakthrough point of vaccine design will facilitate the development of an ASF vaccine. In this review, the paper aims to highlight the recent advances and breakthroughs in the epidemic and transmission of ASF, virus mutation, and the development of vaccines in recent years, focusing on future directions and trends.https://www.frontiersin.org/articles/10.3389/fmicb.2023.1139494/fullAfrican swine fever virusepidemic and spreadvaccineprogressreview |
| spellingShingle | Hongliang Zhang Saisai Zhao Saisai Zhao Haojie Zhang Zhihua Qin Hu Shan Xiulei Cai Vaccines for African swine fever: an update Frontiers in Microbiology African swine fever virus epidemic and spread vaccine progress review |
| title | Vaccines for African swine fever: an update |
| title_full | Vaccines for African swine fever: an update |
| title_fullStr | Vaccines for African swine fever: an update |
| title_full_unstemmed | Vaccines for African swine fever: an update |
| title_short | Vaccines for African swine fever: an update |
| title_sort | vaccines for african swine fever an update |
| topic | African swine fever virus epidemic and spread vaccine progress review |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2023.1139494/full |
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