Insights into Siglec‐7 Binding to Gangliosides: NMR Protein Assignment and the Impact of Ligand Flexibility

Insights into Siglec‐7 Binding to Gangliosides: NMR Protein Assignment and the Impact of Ligand Flexibility

Abstract Gangliosides, sialylated glycosphingolipids abundant in the nervous system, play crucial roles in neurotransmission, interaction with regulatory proteins, cell–cell recognition, and signaling. Altered gangliosides expression has been correlated with pathological processes, including cancer,...

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Main Authors: Cristina Di Carluccio, Luis Padilla‐Cortés, Marta Tiemblo‐Martìn, Giulia Roxana Gheorghita, Rosario Oliva, Linda Cerofolini, Alessandro Antonio Masi, Celeste Abreu, Hsin‐Kai Tseng, Antonio Molinaro, Pompea Del Vecchio, Ondřej Vaněk, Chun‐Cheng Lin, Roberta Marchetti, Marco Fragai, Alba Silipo
Format: Article
Language:English
Published: Wiley 2025-06-01
Series:Advanced Science
Subjects:
gangliosides
NMR
siglec‐7
structural biology
Online Access:https://doi.org/10.1002/advs.202415782
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