Charting the state of GEMs in microalgae: progress, challenges, and innovations
Genome-scale metabolic models (GEMs) provide a systems-level framework for understanding and engineering microalgal metabolism. This review explores the evolution of GEMs in microalgae, highlighting advances in light modeling, automation, and multi-omics integration. Special emphasis is placed on Ch...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-06-01
|
| Series: | Frontiers in Plant Science |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fpls.2025.1614397/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849468936503951360 |
|---|---|
| author | Jacob Tamburro Nanette R. Boyle Nanette R. Boyle |
| author_facet | Jacob Tamburro Nanette R. Boyle Nanette R. Boyle |
| author_sort | Jacob Tamburro |
| collection | DOAJ |
| description | Genome-scale metabolic models (GEMs) provide a systems-level framework for understanding and engineering microalgal metabolism. This review explores the evolution of GEMs in microalgae, highlighting advances in light modeling, automation, and multi-omics integration. Special emphasis is placed on Chlamydomonas reinhardtii as a model species. Limitations of current models, particularly for microalgae, are discussed, alongside promising developments in dynamic modeling and machine learning. Together, these innovations chart a path toward more predictive, adaptable GEMs that can accelerate biotechnological applications of microalgae in sustainable production systems. |
| format | Article |
| id | doaj-art-c6374c39dc8e4fb89074f3f97bf4cc2b |
| institution | Kabale University |
| issn | 1664-462X |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Plant Science |
| spelling | doaj-art-c6374c39dc8e4fb89074f3f97bf4cc2b2025-08-20T03:25:42ZengFrontiers Media S.A.Frontiers in Plant Science1664-462X2025-06-011610.3389/fpls.2025.16143971614397Charting the state of GEMs in microalgae: progress, challenges, and innovationsJacob Tamburro0Nanette R. Boyle1Nanette R. Boyle2Quantitative Biosciences & Engineering, Colorado School of Mines, Golden, CO, United StatesQuantitative Biosciences & Engineering, Colorado School of Mines, Golden, CO, United StatesChemical & Biological Engineering, Colorado School of Mines, Golden, CO, United StatesGenome-scale metabolic models (GEMs) provide a systems-level framework for understanding and engineering microalgal metabolism. This review explores the evolution of GEMs in microalgae, highlighting advances in light modeling, automation, and multi-omics integration. Special emphasis is placed on Chlamydomonas reinhardtii as a model species. Limitations of current models, particularly for microalgae, are discussed, alongside promising developments in dynamic modeling and machine learning. Together, these innovations chart a path toward more predictive, adaptable GEMs that can accelerate biotechnological applications of microalgae in sustainable production systems.https://www.frontiersin.org/articles/10.3389/fpls.2025.1614397/fullmetabolic fluxalgaephotosynthesismodelingmetabolism |
| spellingShingle | Jacob Tamburro Nanette R. Boyle Nanette R. Boyle Charting the state of GEMs in microalgae: progress, challenges, and innovations Frontiers in Plant Science metabolic flux algae photosynthesis modeling metabolism |
| title | Charting the state of GEMs in microalgae: progress, challenges, and innovations |
| title_full | Charting the state of GEMs in microalgae: progress, challenges, and innovations |
| title_fullStr | Charting the state of GEMs in microalgae: progress, challenges, and innovations |
| title_full_unstemmed | Charting the state of GEMs in microalgae: progress, challenges, and innovations |
| title_short | Charting the state of GEMs in microalgae: progress, challenges, and innovations |
| title_sort | charting the state of gems in microalgae progress challenges and innovations |
| topic | metabolic flux algae photosynthesis modeling metabolism |
| url | https://www.frontiersin.org/articles/10.3389/fpls.2025.1614397/full |
| work_keys_str_mv | AT jacobtamburro chartingthestateofgemsinmicroalgaeprogresschallengesandinnovations AT nanetterboyle chartingthestateofgemsinmicroalgaeprogresschallengesandinnovations AT nanetterboyle chartingthestateofgemsinmicroalgaeprogresschallengesandinnovations |