Blood-brain barrier disruption and increased free water are associated with worse cognitive performance in patients with chronic cerebrovascular disease

Blood-brain barrier disruption and increased free water are associated with worse cognitive performance in patients with chronic cerebrovascular disease

Progression of cerebral small vessel disease (CSVD) is associated with cognitive decline. Blood-brain barrier disruption (BBBD) and fluid extravasation to the interstitial space may contribute to progression of white matter hyperintensities (WMH). We hypothesized that increased free water (FW) would...

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Bibliographic Details
Main Authors:	Kyle C. Kern, Marwah S. Zagzoug, Rebecca F. Gottesman, Clinton B. Wright, Richard Leigh
Format:	Article
Language:	English
Published:	Elsevier 2024-01-01
Series:	NeuroImage: Clinical
Subjects:	Magnetic resonance imaging Blood-brain barrier Diffusion tensor imaging Free water Dementia Vascular
Online Access:	http://www.sciencedirect.com/science/article/pii/S2213158224001475
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