Comparison of Mortality Prediction Between the Model for End-Stage Liver Disease-3.0 (MELD-3.0) and the Model for End-Stage Liver Disease-Lactate (MELD-La) in Korean Patients with Liver Cirrhosis
<i>Background and Objectives</i>: The Model for End-Stage Liver Disease (MELD) score has widely been used for mortality prediction in liver cirrhosis (LC) patients and transplantation allocation. There have been recent modifications of MELD scores, such as MELD-Lactate (MELD-La) and MELD...
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MDPI AG
2025-03-01
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| author | Seung-Kang Yoo Jeong-Han Kim Won-Hyeok Choe So-Young Kwon |
| author_facet | Seung-Kang Yoo Jeong-Han Kim Won-Hyeok Choe So-Young Kwon |
| author_sort | Seung-Kang Yoo |
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| description | <i>Background and Objectives</i>: The Model for End-Stage Liver Disease (MELD) score has widely been used for mortality prediction in liver cirrhosis (LC) patients and transplantation allocation. There have been recent modifications of MELD scores, such as MELD-Lactate (MELD-La) and MELD-3.0. The goal of this study was to compare MELD, MELD-La, and MELD-3.0 in predicting mortality among LC patients in Korea. <i>Materials and Methods</i>: This is a retrospective, single-centered study in which LC patients admitted to Konkuk University Hospital between January 2011 and December 2022 were enrolled and reviewed. Predictive values for 1- and 3-month mortality for MELD, MELD-La, and MELD-3.0 were calculated using the area under the receiver operating characteristic (AUROC) curve. Differences between AUROCs were statistically analyzed using DeLong’s test. <i>Results</i>: A total of 1152 patients were initially included in this study. Among them, 165 (14.3%) patients died within one month, and 211 (19.7%) died within three months. The AUROCs for 1-month mortality of MELD, MELD-La, and MELD-3.0 were 0.808, 0.79, and 0.807, respectively. For the 3-month mortality of MELD, MELD-La, and MELD-3.0, the AUROCs were 0.805, 0.753, and 0.817, respectively. Multiple comparisons of ROC curves demonstrated that MELD and MELD-3.0 reflected the 3-month mortality prediction of LC patients better than MELD-La (<i>p</i> = 0.0018, <i>p</i> = 0.0003, respectively). <i>Conclusions</i>: This study demonstrated that MELD and MELD-3.0 outperformed MELD-La in predicting the 3-month mortality for LC patients. However, there was no significant difference between MELD and MELD-3.0 in predicting LC patient mortality. |
| format | Article |
| id | doaj-art-c63151cb230b4c008df36860255b5ed9 |
| institution | OA Journals |
| issn | 1010-660X 1648-9144 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | MDPI AG |
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| series | Medicina |
| spelling | doaj-art-c63151cb230b4c008df36860255b5ed92025-08-20T01:49:00ZengMDPI AGMedicina1010-660X1648-91442025-03-0161349410.3390/medicina61030494Comparison of Mortality Prediction Between the Model for End-Stage Liver Disease-3.0 (MELD-3.0) and the Model for End-Stage Liver Disease-Lactate (MELD-La) in Korean Patients with Liver CirrhosisSeung-Kang Yoo0Jeong-Han Kim1Won-Hyeok Choe2So-Young Kwon3Department of Internal Medicine, Konkuk University Medical Center, Seoul 05030, Republic of KoreaDepartment of Internal Medicine, Konkuk University Medical Center, Seoul 05030, Republic of KoreaDepartment of Internal Medicine, Konkuk University Medical Center, Seoul 05030, Republic of KoreaDepartment of Internal Medicine, Konkuk University Medical Center, Seoul 05030, Republic of Korea<i>Background and Objectives</i>: The Model for End-Stage Liver Disease (MELD) score has widely been used for mortality prediction in liver cirrhosis (LC) patients and transplantation allocation. There have been recent modifications of MELD scores, such as MELD-Lactate (MELD-La) and MELD-3.0. The goal of this study was to compare MELD, MELD-La, and MELD-3.0 in predicting mortality among LC patients in Korea. <i>Materials and Methods</i>: This is a retrospective, single-centered study in which LC patients admitted to Konkuk University Hospital between January 2011 and December 2022 were enrolled and reviewed. Predictive values for 1- and 3-month mortality for MELD, MELD-La, and MELD-3.0 were calculated using the area under the receiver operating characteristic (AUROC) curve. Differences between AUROCs were statistically analyzed using DeLong’s test. <i>Results</i>: A total of 1152 patients were initially included in this study. Among them, 165 (14.3%) patients died within one month, and 211 (19.7%) died within three months. The AUROCs for 1-month mortality of MELD, MELD-La, and MELD-3.0 were 0.808, 0.79, and 0.807, respectively. For the 3-month mortality of MELD, MELD-La, and MELD-3.0, the AUROCs were 0.805, 0.753, and 0.817, respectively. Multiple comparisons of ROC curves demonstrated that MELD and MELD-3.0 reflected the 3-month mortality prediction of LC patients better than MELD-La (<i>p</i> = 0.0018, <i>p</i> = 0.0003, respectively). <i>Conclusions</i>: This study demonstrated that MELD and MELD-3.0 outperformed MELD-La in predicting the 3-month mortality for LC patients. However, there was no significant difference between MELD and MELD-3.0 in predicting LC patient mortality.https://www.mdpi.com/1648-9144/61/3/494MELDMELD-lactateMELD-3.0mortality predictionliver cirrhosis |
| spellingShingle | Seung-Kang Yoo Jeong-Han Kim Won-Hyeok Choe So-Young Kwon Comparison of Mortality Prediction Between the Model for End-Stage Liver Disease-3.0 (MELD-3.0) and the Model for End-Stage Liver Disease-Lactate (MELD-La) in Korean Patients with Liver Cirrhosis Medicina MELD MELD-lactate MELD-3.0 mortality prediction liver cirrhosis |
| title | Comparison of Mortality Prediction Between the Model for End-Stage Liver Disease-3.0 (MELD-3.0) and the Model for End-Stage Liver Disease-Lactate (MELD-La) in Korean Patients with Liver Cirrhosis |
| title_full | Comparison of Mortality Prediction Between the Model for End-Stage Liver Disease-3.0 (MELD-3.0) and the Model for End-Stage Liver Disease-Lactate (MELD-La) in Korean Patients with Liver Cirrhosis |
| title_fullStr | Comparison of Mortality Prediction Between the Model for End-Stage Liver Disease-3.0 (MELD-3.0) and the Model for End-Stage Liver Disease-Lactate (MELD-La) in Korean Patients with Liver Cirrhosis |
| title_full_unstemmed | Comparison of Mortality Prediction Between the Model for End-Stage Liver Disease-3.0 (MELD-3.0) and the Model for End-Stage Liver Disease-Lactate (MELD-La) in Korean Patients with Liver Cirrhosis |
| title_short | Comparison of Mortality Prediction Between the Model for End-Stage Liver Disease-3.0 (MELD-3.0) and the Model for End-Stage Liver Disease-Lactate (MELD-La) in Korean Patients with Liver Cirrhosis |
| title_sort | comparison of mortality prediction between the model for end stage liver disease 3 0 meld 3 0 and the model for end stage liver disease lactate meld la in korean patients with liver cirrhosis |
| topic | MELD MELD-lactate MELD-3.0 mortality prediction liver cirrhosis |
| url | https://www.mdpi.com/1648-9144/61/3/494 |
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