A retrospective comparative study on the treatment of non-metastatic pancreatic cancer using high-intensity focused ultrasound versus radical surgery
Objective To compare the efficacy and safety of high-intensity focused ultrasound (HIFU) and radical surgery for non-metastatic pancreatic cancer (PC).Materials and methods We retrospectively analyzed 89 stage I/II/III PC patients who underwent HIFU (n = 43) or surgery (n = 46) at the Third Xiangya...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2024-12-01
|
| Series: | International Journal of Hyperthermia |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/02656736.2024.2398557 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850083820165922816 |
|---|---|
| author | Li Yu Yunfei Liu Zhiqiang Li Yanyan Huang Guangping Tu Qiuling Shi Lang Chen Xiao Yu |
| author_facet | Li Yu Yunfei Liu Zhiqiang Li Yanyan Huang Guangping Tu Qiuling Shi Lang Chen Xiao Yu |
| author_sort | Li Yu |
| collection | DOAJ |
| description | Objective To compare the efficacy and safety of high-intensity focused ultrasound (HIFU) and radical surgery for non-metastatic pancreatic cancer (PC).Materials and methods We retrospectively analyzed 89 stage I/II/III PC patients who underwent HIFU (n = 43) or surgery (n = 46) at the Third Xiangya Hospital from January 2020 to December 2021. Pain relief, Karnofsky Performance Scale (KPS), overall survival (OS), treatment-related complications and risk factors for OS were assessed.Results There was no significant difference in the pain relief rate at 30 days post-treatment between the two groups. However, compared with the surgery group, the HIFU group showed significantly lower post-treatment VAS scores (p = 0.019). In the surgery group, the KPS at 30 days post-treatment was lower than pretreatment KPS (70 vs 80; p = 0.015). This relationship was reversed in the HIFU group (80 vs 70; p = 0.024). Median OS favored surgery over HIFU (23 vs 10 months; p < 0.001), with a higher 1-year OS rate (69.57% vs 32.6%; p < 0.001). However, there was no significant difference in OS between the two groups for stage III patients (p = 0.177). Complications rated ≥ grade III were 2.33% in the HIFU group and 32.6% in the surgery group. Multivariate analyses showed that age, KPS, and treatment methods were independent prognostic factors for OS.Conclusion HIFU demonstrates advantages over surgery in terms of early KPS, VAS improvements, and safety for pancreatic cancer; however, long-term outcomes favor surgery. For III-stage disease, HIFU was noninferior to surgery in overall survival. |
| format | Article |
| id | doaj-art-c62ae79ccfac489f9a1384e9bfd2a804 |
| institution | DOAJ |
| issn | 0265-6736 1464-5157 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | International Journal of Hyperthermia |
| spelling | doaj-art-c62ae79ccfac489f9a1384e9bfd2a8042025-08-20T02:44:12ZengTaylor & Francis GroupInternational Journal of Hyperthermia0265-67361464-51572024-12-0141110.1080/02656736.2024.2398557A retrospective comparative study on the treatment of non-metastatic pancreatic cancer using high-intensity focused ultrasound versus radical surgeryLi Yu0Yunfei Liu1Zhiqiang Li2Yanyan Huang3Guangping Tu4Qiuling Shi5Lang Chen6Xiao Yu7Department of Hepatopancreatobiliary Surgery, Third Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Hepatopancreatobiliary Surgery, Third Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Hepatopancreatobiliary Surgery, Third Xiangya Hospital, Central South University, Changsha, ChinaSchool of Public Health, Chongqing Medical University, Chongqing, ChinaDepartment of Hepatopancreatobiliary Surgery, Third Xiangya Hospital, Central South University, Changsha, ChinaSchool of Public Health, Chongqing Medical University, Chongqing, ChinaDepartment of Hepatopancreatobiliary Surgery, Third Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Hepatopancreatobiliary Surgery, Third Xiangya Hospital, Central South University, Changsha, ChinaObjective To compare the efficacy and safety of high-intensity focused ultrasound (HIFU) and radical surgery for non-metastatic pancreatic cancer (PC).Materials and methods We retrospectively analyzed 89 stage I/II/III PC patients who underwent HIFU (n = 43) or surgery (n = 46) at the Third Xiangya Hospital from January 2020 to December 2021. Pain relief, Karnofsky Performance Scale (KPS), overall survival (OS), treatment-related complications and risk factors for OS were assessed.Results There was no significant difference in the pain relief rate at 30 days post-treatment between the two groups. However, compared with the surgery group, the HIFU group showed significantly lower post-treatment VAS scores (p = 0.019). In the surgery group, the KPS at 30 days post-treatment was lower than pretreatment KPS (70 vs 80; p = 0.015). This relationship was reversed in the HIFU group (80 vs 70; p = 0.024). Median OS favored surgery over HIFU (23 vs 10 months; p < 0.001), with a higher 1-year OS rate (69.57% vs 32.6%; p < 0.001). However, there was no significant difference in OS between the two groups for stage III patients (p = 0.177). Complications rated ≥ grade III were 2.33% in the HIFU group and 32.6% in the surgery group. Multivariate analyses showed that age, KPS, and treatment methods were independent prognostic factors for OS.Conclusion HIFU demonstrates advantages over surgery in terms of early KPS, VAS improvements, and safety for pancreatic cancer; however, long-term outcomes favor surgery. For III-stage disease, HIFU was noninferior to surgery in overall survival.https://www.tandfonline.com/doi/10.1080/02656736.2024.2398557HIFUpancreatic cancersurgerysurvivalpain reliefKarnofsky Performance Scale |
| spellingShingle | Li Yu Yunfei Liu Zhiqiang Li Yanyan Huang Guangping Tu Qiuling Shi Lang Chen Xiao Yu A retrospective comparative study on the treatment of non-metastatic pancreatic cancer using high-intensity focused ultrasound versus radical surgery International Journal of Hyperthermia HIFU pancreatic cancer surgery survival pain relief Karnofsky Performance Scale |
| title | A retrospective comparative study on the treatment of non-metastatic pancreatic cancer using high-intensity focused ultrasound versus radical surgery |
| title_full | A retrospective comparative study on the treatment of non-metastatic pancreatic cancer using high-intensity focused ultrasound versus radical surgery |
| title_fullStr | A retrospective comparative study on the treatment of non-metastatic pancreatic cancer using high-intensity focused ultrasound versus radical surgery |
| title_full_unstemmed | A retrospective comparative study on the treatment of non-metastatic pancreatic cancer using high-intensity focused ultrasound versus radical surgery |
| title_short | A retrospective comparative study on the treatment of non-metastatic pancreatic cancer using high-intensity focused ultrasound versus radical surgery |
| title_sort | retrospective comparative study on the treatment of non metastatic pancreatic cancer using high intensity focused ultrasound versus radical surgery |
| topic | HIFU pancreatic cancer surgery survival pain relief Karnofsky Performance Scale |
| url | https://www.tandfonline.com/doi/10.1080/02656736.2024.2398557 |
| work_keys_str_mv | AT liyu aretrospectivecomparativestudyonthetreatmentofnonmetastaticpancreaticcancerusinghighintensityfocusedultrasoundversusradicalsurgery AT yunfeiliu aretrospectivecomparativestudyonthetreatmentofnonmetastaticpancreaticcancerusinghighintensityfocusedultrasoundversusradicalsurgery AT zhiqiangli aretrospectivecomparativestudyonthetreatmentofnonmetastaticpancreaticcancerusinghighintensityfocusedultrasoundversusradicalsurgery AT yanyanhuang aretrospectivecomparativestudyonthetreatmentofnonmetastaticpancreaticcancerusinghighintensityfocusedultrasoundversusradicalsurgery AT guangpingtu aretrospectivecomparativestudyonthetreatmentofnonmetastaticpancreaticcancerusinghighintensityfocusedultrasoundversusradicalsurgery AT qiulingshi aretrospectivecomparativestudyonthetreatmentofnonmetastaticpancreaticcancerusinghighintensityfocusedultrasoundversusradicalsurgery AT langchen aretrospectivecomparativestudyonthetreatmentofnonmetastaticpancreaticcancerusinghighintensityfocusedultrasoundversusradicalsurgery AT xiaoyu aretrospectivecomparativestudyonthetreatmentofnonmetastaticpancreaticcancerusinghighintensityfocusedultrasoundversusradicalsurgery AT liyu retrospectivecomparativestudyonthetreatmentofnonmetastaticpancreaticcancerusinghighintensityfocusedultrasoundversusradicalsurgery AT yunfeiliu retrospectivecomparativestudyonthetreatmentofnonmetastaticpancreaticcancerusinghighintensityfocusedultrasoundversusradicalsurgery AT zhiqiangli retrospectivecomparativestudyonthetreatmentofnonmetastaticpancreaticcancerusinghighintensityfocusedultrasoundversusradicalsurgery AT yanyanhuang retrospectivecomparativestudyonthetreatmentofnonmetastaticpancreaticcancerusinghighintensityfocusedultrasoundversusradicalsurgery AT guangpingtu retrospectivecomparativestudyonthetreatmentofnonmetastaticpancreaticcancerusinghighintensityfocusedultrasoundversusradicalsurgery AT qiulingshi retrospectivecomparativestudyonthetreatmentofnonmetastaticpancreaticcancerusinghighintensityfocusedultrasoundversusradicalsurgery AT langchen retrospectivecomparativestudyonthetreatmentofnonmetastaticpancreaticcancerusinghighintensityfocusedultrasoundversusradicalsurgery AT xiaoyu retrospectivecomparativestudyonthetreatmentofnonmetastaticpancreaticcancerusinghighintensityfocusedultrasoundversusradicalsurgery |