Expression of Cyclin D1 in Hyperplastic and Neoplastic Endometrial Lesions
Objective: To observe and evaluate the expression of Cyclin D1 in hyperplastic and neoplastic endometrial lesions. Methodology: This .retrospective analytical study was conducted at BMSI, JPMC over a five year period i.e. from 1-1-2008 to 31-1-2012 and was based on the analysis of endometrial sampl...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Bahria Univerisy Health Sciences, Campus Karachi
2017-03-01
|
| Series: | Journal of Bahria University Medical and Dental College |
| Subjects: | |
| Online Access: | https://jbumdc.bahria.edu.pk/index.php/ojs/article/view/228 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850080070230605824 |
|---|---|
| author | Summayya Shawana Saleha Masood Zamir Ali Siddiqui |
| author_facet | Summayya Shawana Saleha Masood Zamir Ali Siddiqui |
| author_sort | Summayya Shawana |
| collection | DOAJ |
| description |
Objective: To observe and evaluate the expression of Cyclin D1 in hyperplastic and neoplastic endometrial lesions.
Methodology: This .retrospective analytical study was conducted at BMSI, JPMC over a five year period i.e. from 1-1-2008
to 31-1-2012 and was based on the analysis of endometrial samples comprising of hysterectomies and curettage. 55 endometrial
samples including 25 malignant endometrial lesions, 6 complex hyperplasia with atypia, 14 complex hyperplasia without atypia,
6 simple hyperplasia without atypia, and 4 normal proliferative endometrium were analyzed for results of immunohistochemical
staining.
Results: 44% (11 out of 25) cases of malignant endometrial lesions showed Cyclin D1 over expression. 66.66% (4 out of 6)
cases of endometrial hyperplasia with atypia and 50% (7 out of 14) cases of endometrial hyperplasia without atypia showed
Cyclin D1 overexpression.
Conclusion: Cyclin D1 overexpression was seen in a significant number of well differentiated endometrial adenocarcinomas
and complex hyperplasia with atypia suggesting it to be an early event in endometrial carcinogenesis.
|
| format | Article |
| id | doaj-art-c62a12cada404434bb2d2d4118da006b |
| institution | DOAJ |
| issn | 2220-7562 2617-9482 |
| language | English |
| publishDate | 2017-03-01 |
| publisher | Bahria Univerisy Health Sciences, Campus Karachi |
| record_format | Article |
| series | Journal of Bahria University Medical and Dental College |
| spelling | doaj-art-c62a12cada404434bb2d2d4118da006b2025-08-20T02:45:02ZengBahria Univerisy Health Sciences, Campus KarachiJournal of Bahria University Medical and Dental College2220-75622617-94822017-03-0171Expression of Cyclin D1 in Hyperplastic and Neoplastic Endometrial LesionsSummayya ShawanaSaleha MasoodZamir Ali Siddiqui Objective: To observe and evaluate the expression of Cyclin D1 in hyperplastic and neoplastic endometrial lesions. Methodology: This .retrospective analytical study was conducted at BMSI, JPMC over a five year period i.e. from 1-1-2008 to 31-1-2012 and was based on the analysis of endometrial samples comprising of hysterectomies and curettage. 55 endometrial samples including 25 malignant endometrial lesions, 6 complex hyperplasia with atypia, 14 complex hyperplasia without atypia, 6 simple hyperplasia without atypia, and 4 normal proliferative endometrium were analyzed for results of immunohistochemical staining. Results: 44% (11 out of 25) cases of malignant endometrial lesions showed Cyclin D1 over expression. 66.66% (4 out of 6) cases of endometrial hyperplasia with atypia and 50% (7 out of 14) cases of endometrial hyperplasia without atypia showed Cyclin D1 overexpression. Conclusion: Cyclin D1 overexpression was seen in a significant number of well differentiated endometrial adenocarcinomas and complex hyperplasia with atypia suggesting it to be an early event in endometrial carcinogenesis. https://jbumdc.bahria.edu.pk/index.php/ojs/article/view/228Atypia, Cyclin D1 overexpression, Early event, Endometrial carcinoma, Hyperplasia |
| spellingShingle | Summayya Shawana Saleha Masood Zamir Ali Siddiqui Expression of Cyclin D1 in Hyperplastic and Neoplastic Endometrial Lesions Journal of Bahria University Medical and Dental College Atypia, Cyclin D1 overexpression, Early event, Endometrial carcinoma, Hyperplasia |
| title | Expression of Cyclin D1 in Hyperplastic and Neoplastic Endometrial Lesions |
| title_full | Expression of Cyclin D1 in Hyperplastic and Neoplastic Endometrial Lesions |
| title_fullStr | Expression of Cyclin D1 in Hyperplastic and Neoplastic Endometrial Lesions |
| title_full_unstemmed | Expression of Cyclin D1 in Hyperplastic and Neoplastic Endometrial Lesions |
| title_short | Expression of Cyclin D1 in Hyperplastic and Neoplastic Endometrial Lesions |
| title_sort | expression of cyclin d1 in hyperplastic and neoplastic endometrial lesions |
| topic | Atypia, Cyclin D1 overexpression, Early event, Endometrial carcinoma, Hyperplasia |
| url | https://jbumdc.bahria.edu.pk/index.php/ojs/article/view/228 |
| work_keys_str_mv | AT summayyashawana expressionofcyclind1inhyperplasticandneoplasticendometriallesions AT salehamasood expressionofcyclind1inhyperplasticandneoplasticendometriallesions AT zamiralisiddiqui expressionofcyclind1inhyperplasticandneoplasticendometriallesions |