STUDYING ASSOCIATIONS OF TWO COMMON S27P AND -15С→T POLYMORPHISMS OF THE INTERLEUKIN-3 GENE WITH DEVELOPMENT OF ALLERGIC AND NON-ALLERGIC BRONCHIAL ASTHMA IN RUSSIANS FROM THE CENTRAL-CHERNOZEM REGION
Abstract. The purpose of our study was to investigate whether S27P and -15С→T single nucleotide polymorphisms of the IL3 gene are associated with susceptibility to bronchial asthma (BA) in Russians living in the Central-Chernozem region of Russia. DNA samples obtained from 216 unrelated patients wit...
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| Format: | Article |
| Language: | Russian |
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St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2014-07-01
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| Series: | Медицинская иммунология |
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| Online Access: | https://www.mimmun.ru/mimmun/article/view/587 |
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| author | A. V. Polonikov V. P. Ivanov D. A. Belugin I. V. Khoroshaya M. A. Solodilova V. I. Panfilov |
| author_facet | A. V. Polonikov V. P. Ivanov D. A. Belugin I. V. Khoroshaya M. A. Solodilova V. I. Panfilov |
| author_sort | A. V. Polonikov |
| collection | DOAJ |
| description | Abstract. The purpose of our study was to investigate whether S27P and -15С→T single nucleotide polymorphisms of the IL3 gene are associated with susceptibility to bronchial asthma (BA) in Russians living in the Central-Chernozem region of Russia. DNA samples obtained from 216 unrelated patients with BA and 214 healthy controls were typed for S27P and -15С→T polymorphisms in the IL3 gene by PCR-RFLP methods. Gender-based differences in the distribution of IL3 genotypes have been revealed between controls and patients with asthma. Both S27P and -15С→T polymorphisms were found to associate with common susceptibility to BA predominantly in females (p=0,05). Studied genetic variants of IL3 gene were in strong linkage disequilibrium with each other (p<0,0001). Further studies are required to investigate phenotypic expression of S27P and -15С→T polymorphisms of IL3 gene and to clarify their roles in the pathogenesis of bronchial asthma. |
| format | Article |
| id | doaj-art-c62a0e6fe1da438ab19858fda753fe4b |
| institution | Kabale University |
| issn | 1563-0625 2313-741X |
| language | Russian |
| publishDate | 2014-07-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj-art-c62a0e6fe1da438ab19858fda753fe4b2025-08-20T03:37:46ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2014-07-0185-673173610.15789/1563-0625-2006-5-6-731-736584STUDYING ASSOCIATIONS OF TWO COMMON S27P AND -15С→T POLYMORPHISMS OF THE INTERLEUKIN-3 GENE WITH DEVELOPMENT OF ALLERGIC AND NON-ALLERGIC BRONCHIAL ASTHMA IN RUSSIANS FROM THE CENTRAL-CHERNOZEM REGIONA. V. Polonikov0V. P. Ivanov1D. A. Belugin2I. V. Khoroshaya3M. A. Solodilova4V. I. Panfilov5Курский государственный медицинский университетКурский государственный медицинский университетКурский государственный университетКурский государственный медицинский университетКурский государственный медицинский университетКурская областная клиническая больница, г. КурскAbstract. The purpose of our study was to investigate whether S27P and -15С→T single nucleotide polymorphisms of the IL3 gene are associated with susceptibility to bronchial asthma (BA) in Russians living in the Central-Chernozem region of Russia. DNA samples obtained from 216 unrelated patients with BA and 214 healthy controls were typed for S27P and -15С→T polymorphisms in the IL3 gene by PCR-RFLP methods. Gender-based differences in the distribution of IL3 genotypes have been revealed between controls and patients with asthma. Both S27P and -15С→T polymorphisms were found to associate with common susceptibility to BA predominantly in females (p=0,05). Studied genetic variants of IL3 gene were in strong linkage disequilibrium with each other (p<0,0001). Further studies are required to investigate phenotypic expression of S27P and -15С→T polymorphisms of IL3 gene and to clarify their roles in the pathogenesis of bronchial asthma.https://www.mimmun.ru/mimmun/article/view/587bronchial asthmail-3single nucleotide polymorphismsgenetic susceptibility |
| spellingShingle | A. V. Polonikov V. P. Ivanov D. A. Belugin I. V. Khoroshaya M. A. Solodilova V. I. Panfilov STUDYING ASSOCIATIONS OF TWO COMMON S27P AND -15С→T POLYMORPHISMS OF THE INTERLEUKIN-3 GENE WITH DEVELOPMENT OF ALLERGIC AND NON-ALLERGIC BRONCHIAL ASTHMA IN RUSSIANS FROM THE CENTRAL-CHERNOZEM REGION Медицинская иммунология bronchial asthma il-3 single nucleotide polymorphisms genetic susceptibility |
| title | STUDYING ASSOCIATIONS OF TWO COMMON S27P AND -15С→T POLYMORPHISMS OF THE INTERLEUKIN-3 GENE WITH DEVELOPMENT OF ALLERGIC AND NON-ALLERGIC BRONCHIAL ASTHMA IN RUSSIANS FROM THE CENTRAL-CHERNOZEM REGION |
| title_full | STUDYING ASSOCIATIONS OF TWO COMMON S27P AND -15С→T POLYMORPHISMS OF THE INTERLEUKIN-3 GENE WITH DEVELOPMENT OF ALLERGIC AND NON-ALLERGIC BRONCHIAL ASTHMA IN RUSSIANS FROM THE CENTRAL-CHERNOZEM REGION |
| title_fullStr | STUDYING ASSOCIATIONS OF TWO COMMON S27P AND -15С→T POLYMORPHISMS OF THE INTERLEUKIN-3 GENE WITH DEVELOPMENT OF ALLERGIC AND NON-ALLERGIC BRONCHIAL ASTHMA IN RUSSIANS FROM THE CENTRAL-CHERNOZEM REGION |
| title_full_unstemmed | STUDYING ASSOCIATIONS OF TWO COMMON S27P AND -15С→T POLYMORPHISMS OF THE INTERLEUKIN-3 GENE WITH DEVELOPMENT OF ALLERGIC AND NON-ALLERGIC BRONCHIAL ASTHMA IN RUSSIANS FROM THE CENTRAL-CHERNOZEM REGION |
| title_short | STUDYING ASSOCIATIONS OF TWO COMMON S27P AND -15С→T POLYMORPHISMS OF THE INTERLEUKIN-3 GENE WITH DEVELOPMENT OF ALLERGIC AND NON-ALLERGIC BRONCHIAL ASTHMA IN RUSSIANS FROM THE CENTRAL-CHERNOZEM REGION |
| title_sort | studying associations of two common s27p and 15с t polymorphisms of the interleukin 3 gene with development of allergic and non allergic bronchial asthma in russians from the central chernozem region |
| topic | bronchial asthma il-3 single nucleotide polymorphisms genetic susceptibility |
| url | https://www.mimmun.ru/mimmun/article/view/587 |
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