Deciphering hypothalamic pathology in ALS: insights into non-motor symptoms and disease progression

Deciphering hypothalamic pathology in ALS: insights into non-motor symptoms and disease progression

Summary: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with highly heterogeneous clinical presentations. Among the non-motor features increasingly recognised as clinically relevant is the dysregulation of energy balance, with weight loss—particularly due to fat mass loss—e...

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Bibliographic Details
Main Authors: Jeryn Chang, Annissa H. Teo, Thomas B. Shaw, Luc Dupuis, Shyuan T. Ngo, Frederik J. Steyn
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:EBioMedicine
Subjects:
Hypothalamic pathology
Metabolic dysregulation
Non-motor symptoms
Neuroimaging
Neuroendocrine dysfunction
Multisystem disease
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396425002890
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