Effect of Silver Nanoparticle Size on Antibacterial Activity
The ubiquitous use of products containing AgNPs results in the entry of nanoparticles into the environment. Both nanoparticles and Ag<sup>+</sup> released upon their oxidative dissolution have a toxic effect on living microorganisms. The antibacterial activity of spherical silver nanopar...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-11-01
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| Series: | Toxics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2305-6304/12/11/801 |
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| Summary: | The ubiquitous use of products containing AgNPs results in the entry of nanoparticles into the environment. Both nanoparticles and Ag<sup>+</sup> released upon their oxidative dissolution have a toxic effect on living microorganisms. The antibacterial activity of spherical silver nanoparticles of 10.8 ± 0.8 nm and 22.7 ± 2.2 nm in size stabilized by carbonate ions was studied against <i>Escherichia coli</i> and other bacteria. The biocidal action of silver increases as the particle size decreases. Analysis of these results and other known data made it possible to substantiate a linear proportional relationship between the minimum inhibitory concentration (MIC) or the half-maximal inhibitory concentration (IC50) and silver nanoparticle size and determine empirical parameters for this relationship. The antibacterial activity (toxicity) is directly proportional to the specific surface area of nanosized silver. |
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| ISSN: | 2305-6304 |