The mechanistic basis for interprotomer deglycosylation of antibodies by corynebacterial IgG-specific endoglycosidases

The mechanistic basis for interprotomer deglycosylation of antibodies by corynebacterial IgG-specific endoglycosidases

Abstract Corynebacterium diphtheriae clade species secrete single-domain endo-β-N-acetylglucosaminidases (ENGases) that specifically bind to human IgG antibodies and hydrolyze their N297-linked glycans. Here, we define the molecular mechanisms of IgG-specific deglycosylation for the entire family of...

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Main Authors: Diego E. Sastre, Stylianos Bournazos, Maros Huliciak, Barbara Ann C. Grace, E. Josephine Boder, Jonathan Du, Nazneen Sultana, Tala Azzam, Trenton J. Brown, Maria W. Flowers, Pete Lollar, Ting Xu, Tatiana A. Chernova, Alasdair D. Keith, Meredith Keen, Abigail Saltzman, Ana Martinez Gascueña, Beatriz Trastoy, Marcelo E. Guerin, Filipp Frank, Eric A. Ortlund, Jeffrey V. Ravetch, Eric J. Sundberg
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60986-w
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