Expansion of maltose/sucrose related transporters in Ascomycetes and their association with corresponding disaccharide utilization
Sugar transporters (STs) play a crucial role in mediating sugar uptake in fungi and have been increasingly studied due to their important biological roles and industrial potential. In this study, we performed a comprehensive phylogenetic analysis of STs across the fungal kingdom, including species f...
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| Language: | English |
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Elsevier
2025-01-01
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| Series: | Current Research in Microbial Sciences |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666517425000306 |
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| author | Li Xu Alessia Manassero Berend Snel Ronald P. de Vries Mao Peng |
| author_facet | Li Xu Alessia Manassero Berend Snel Ronald P. de Vries Mao Peng |
| author_sort | Li Xu |
| collection | DOAJ |
| description | Sugar transporters (STs) play a crucial role in mediating sugar uptake in fungi and have been increasingly studied due to their important biological roles and industrial potential. In this study, we performed a comprehensive phylogenetic analysis of STs across the fungal kingdom, including species from Ascomycota, Basidiomycota, Mucoromycota and Zoopagomycota. The results revealed a striking diversity of STs among these fungal phyla with respect to their genomic content and predicted sugar specificity. Particularly, we identified a remarkable expansion of maltose/sucrose STs and a strong co-expansion of intracellular α-1,4-glucosidases and invertases in Ascomycota compared to other fungal phyla. In addition, growth profiles support that the utilization of maltose and sucrose across a diverse set of fungi is roughly determined by the presence of both corresponding STs and functionally related hydrolases. This study enhances our understanding of evolutional diversity of fungal STs and provides new insights into metabolic engineering of fungi towards more efficient conversion of plant-derived sugars for relevant industrial applications. |
| format | Article |
| id | doaj-art-c6229deca766456a809f8dba3a34186e |
| institution | OA Journals |
| issn | 2666-5174 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Current Research in Microbial Sciences |
| spelling | doaj-art-c6229deca766456a809f8dba3a34186e2025-08-20T02:09:11ZengElsevierCurrent Research in Microbial Sciences2666-51742025-01-01810036810.1016/j.crmicr.2025.100368Expansion of maltose/sucrose related transporters in Ascomycetes and their association with corresponding disaccharide utilizationLi Xu0Alessia Manassero1Berend Snel2Ronald P. de Vries3Mao Peng4Fungal Physiology, Westerdijk Fungal Biodiversity Institute, Uppsalalaan 8, 3584 CT, Utrecht, The NetherlandsFungal Physiology, Westerdijk Fungal Biodiversity Institute, Uppsalalaan 8, 3584 CT, Utrecht, The NetherlandsTheoretical Biology and Bioinformatics, Biology, Science Faculty, Utrecht University, Padualaan 8, 3584 CH, Utrecht, The NetherlandsFungal Physiology, Westerdijk Fungal Biodiversity Institute, Uppsalalaan 8, 3584 CT, Utrecht, The Netherlands; Corresponding authors.Fungal Physiology, Westerdijk Fungal Biodiversity Institute, Uppsalalaan 8, 3584 CT, Utrecht, The Netherlands; Corresponding authors.Sugar transporters (STs) play a crucial role in mediating sugar uptake in fungi and have been increasingly studied due to their important biological roles and industrial potential. In this study, we performed a comprehensive phylogenetic analysis of STs across the fungal kingdom, including species from Ascomycota, Basidiomycota, Mucoromycota and Zoopagomycota. The results revealed a striking diversity of STs among these fungal phyla with respect to their genomic content and predicted sugar specificity. Particularly, we identified a remarkable expansion of maltose/sucrose STs and a strong co-expansion of intracellular α-1,4-glucosidases and invertases in Ascomycota compared to other fungal phyla. In addition, growth profiles support that the utilization of maltose and sucrose across a diverse set of fungi is roughly determined by the presence of both corresponding STs and functionally related hydrolases. This study enhances our understanding of evolutional diversity of fungal STs and provides new insights into metabolic engineering of fungi towards more efficient conversion of plant-derived sugars for relevant industrial applications.http://www.sciencedirect.com/science/article/pii/S2666517425000306Sugar transporterFungiEvolutionAscomycota |
| spellingShingle | Li Xu Alessia Manassero Berend Snel Ronald P. de Vries Mao Peng Expansion of maltose/sucrose related transporters in Ascomycetes and their association with corresponding disaccharide utilization Current Research in Microbial Sciences Sugar transporter Fungi Evolution Ascomycota |
| title | Expansion of maltose/sucrose related transporters in Ascomycetes and their association with corresponding disaccharide utilization |
| title_full | Expansion of maltose/sucrose related transporters in Ascomycetes and their association with corresponding disaccharide utilization |
| title_fullStr | Expansion of maltose/sucrose related transporters in Ascomycetes and their association with corresponding disaccharide utilization |
| title_full_unstemmed | Expansion of maltose/sucrose related transporters in Ascomycetes and their association with corresponding disaccharide utilization |
| title_short | Expansion of maltose/sucrose related transporters in Ascomycetes and their association with corresponding disaccharide utilization |
| title_sort | expansion of maltose sucrose related transporters in ascomycetes and their association with corresponding disaccharide utilization |
| topic | Sugar transporter Fungi Evolution Ascomycota |
| url | http://www.sciencedirect.com/science/article/pii/S2666517425000306 |
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