Risk factors and the level of laboratory biomarkers abnormalities amongst COVID-19 admitted patients with acute kidney injury: A retrospective cross-sectional study
Introduction: Infection with SARS-CoV-2 might lead to severe acute kidney injury (AKI) with high morbidity and mortality. Various incidence rates of AKI have been reported among hospitalized patients with COVID-19. Our study aimed to investigate the risk factors associated with AKI in hospitalized C...
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| Format: | Article |
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Tabriz University of Medical Sciences Press
2024-07-01
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| Series: | Journal of Research in Clinical Medicine |
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| Online Access: | https://jrcm.tbzmed.ac.ir/PDF/jrcm-12-15.pdf |
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| author | Mahdi Zarei Juan Carlos Cotrina-Aliaga Samaneh Atbaeitabari Mohammad Darvishi Sepideh KarkonShayan Reza Akhavan-Sigari |
| author_facet | Mahdi Zarei Juan Carlos Cotrina-Aliaga Samaneh Atbaeitabari Mohammad Darvishi Sepideh KarkonShayan Reza Akhavan-Sigari |
| author_sort | Mahdi Zarei |
| collection | DOAJ |
| description | Introduction: Infection with SARS-CoV-2 might lead to severe acute kidney injury (AKI) with high morbidity and mortality. Various incidence rates of AKI have been reported among hospitalized patients with COVID-19. Our study aimed to investigate the risk factors associated with AKI in hospitalized COVID-19 patients and the relevant changes in their blood biomarkers compared to COVID-19 patients without AKI. Methods: In this retrospective cross-sectional study, 262 COVID-19-confirmed hospitalized patients were enrolled in the Department of Internal Medicine at Bohlool teaching hospital, Iran, from September 2019 to January 2020. Then, the information related to demographics, medical history, comorbid conditions, and clinical and laboratory findings was documented. Patients were categorized into two groups: Patients without AKI and patients with AKI. Results: We detected 130 (49.6%) patients with AKI among the total number of 262 patients admitted with COVID-19. A total of 68 (25.9%) patients had severe disease, and fever (47.1%) was the most common presenting symptom. Older age, comorbid cardiovascular diseases (CVD), and severe COVID-19 were significantly associated with higher risk of AKI. Abnormal levels of white blood cells (WBC), neutrophil count, hemoglobin (Hb), prothrombin time (PT), international normalized ratio (INR), D-dimer, C-reactive protein (CRP), alkaline phosphatase (ALP), direct bilirubin, blood urea nitrogen (BUN), creatinine, potassium (K), ferritin (in female patients), albumin (Alb), pH, and oxygen saturation (SPO2 ) was significantly associated with a higher risk of developing AKI in COVID-19 patients. Conclusion: AKI was a common condition among COVID-19 patients in our sample. Our study confirms the effect of COVID-19 on the developing of AKI. The association between blood biomarkers, including hematologic and inflammatory markers indicate their potential role in the impairment of kidney function. |
| format | Article |
| id | doaj-art-c61fe9b9de174a60be2c856d08bb35c6 |
| institution | OA Journals |
| issn | 2717-0616 |
| language | English |
| publishDate | 2024-07-01 |
| publisher | Tabriz University of Medical Sciences Press |
| record_format | Article |
| series | Journal of Research in Clinical Medicine |
| spelling | doaj-art-c61fe9b9de174a60be2c856d08bb35c62025-08-20T01:58:04ZengTabriz University of Medical Sciences PressJournal of Research in Clinical Medicine2717-06162024-07-01121151510.34172/jrcm.32247jrcm-32247Risk factors and the level of laboratory biomarkers abnormalities amongst COVID-19 admitted patients with acute kidney injury: A retrospective cross-sectional studyMahdi Zarei0Juan Carlos Cotrina-Aliaga1Samaneh Atbaeitabari2Mohammad Darvishi3Sepideh KarkonShayan4Reza Akhavan-Sigari5Research Center for Evidence-Based Medicine, Tabriz University of Medical Sciences, Tabriz, IranFacultad de Ingenieria, Universidad Peruana los Andes, Huancayo, PeruDepartment of Anesthesiology and Critical Care Medicine, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, IranInfectious Diseases and Tropical Medicine Research Center (IDTMRC), Department of Aerospace and Subaquatic Medicine, AJA University of Medical Sciences, Tehran, IranStudent Research Committee, School of Medicine, Gonabad University of Medical Sciences, Gonabad, IranDepartment of Health Care Management and Clinical Research, Collegium Humanum Warsaw Management University Warsaw, PolandIntroduction: Infection with SARS-CoV-2 might lead to severe acute kidney injury (AKI) with high morbidity and mortality. Various incidence rates of AKI have been reported among hospitalized patients with COVID-19. Our study aimed to investigate the risk factors associated with AKI in hospitalized COVID-19 patients and the relevant changes in their blood biomarkers compared to COVID-19 patients without AKI. Methods: In this retrospective cross-sectional study, 262 COVID-19-confirmed hospitalized patients were enrolled in the Department of Internal Medicine at Bohlool teaching hospital, Iran, from September 2019 to January 2020. Then, the information related to demographics, medical history, comorbid conditions, and clinical and laboratory findings was documented. Patients were categorized into two groups: Patients without AKI and patients with AKI. Results: We detected 130 (49.6%) patients with AKI among the total number of 262 patients admitted with COVID-19. A total of 68 (25.9%) patients had severe disease, and fever (47.1%) was the most common presenting symptom. Older age, comorbid cardiovascular diseases (CVD), and severe COVID-19 were significantly associated with higher risk of AKI. Abnormal levels of white blood cells (WBC), neutrophil count, hemoglobin (Hb), prothrombin time (PT), international normalized ratio (INR), D-dimer, C-reactive protein (CRP), alkaline phosphatase (ALP), direct bilirubin, blood urea nitrogen (BUN), creatinine, potassium (K), ferritin (in female patients), albumin (Alb), pH, and oxygen saturation (SPO2 ) was significantly associated with a higher risk of developing AKI in COVID-19 patients. Conclusion: AKI was a common condition among COVID-19 patients in our sample. Our study confirms the effect of COVID-19 on the developing of AKI. The association between blood biomarkers, including hematologic and inflammatory markers indicate their potential role in the impairment of kidney function.https://jrcm.tbzmed.ac.ir/PDF/jrcm-12-15.pdfacute kidney injuryblood biomarkerscovid-19mortalityrisk factors |
| spellingShingle | Mahdi Zarei Juan Carlos Cotrina-Aliaga Samaneh Atbaeitabari Mohammad Darvishi Sepideh KarkonShayan Reza Akhavan-Sigari Risk factors and the level of laboratory biomarkers abnormalities amongst COVID-19 admitted patients with acute kidney injury: A retrospective cross-sectional study Journal of Research in Clinical Medicine acute kidney injury blood biomarkers covid-19 mortality risk factors |
| title | Risk factors and the level of laboratory biomarkers abnormalities amongst COVID-19 admitted patients with acute kidney injury: A retrospective cross-sectional study |
| title_full | Risk factors and the level of laboratory biomarkers abnormalities amongst COVID-19 admitted patients with acute kidney injury: A retrospective cross-sectional study |
| title_fullStr | Risk factors and the level of laboratory biomarkers abnormalities amongst COVID-19 admitted patients with acute kidney injury: A retrospective cross-sectional study |
| title_full_unstemmed | Risk factors and the level of laboratory biomarkers abnormalities amongst COVID-19 admitted patients with acute kidney injury: A retrospective cross-sectional study |
| title_short | Risk factors and the level of laboratory biomarkers abnormalities amongst COVID-19 admitted patients with acute kidney injury: A retrospective cross-sectional study |
| title_sort | risk factors and the level of laboratory biomarkers abnormalities amongst covid 19 admitted patients with acute kidney injury a retrospective cross sectional study |
| topic | acute kidney injury blood biomarkers covid-19 mortality risk factors |
| url | https://jrcm.tbzmed.ac.ir/PDF/jrcm-12-15.pdf |
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