An Addendum to the Chemiosmotic Theory of Mitochondrial Activity: The Role of RNA as a Proton Sink
Mitochondrial ATP synthesis is driven by harnessing the electrochemical gradient of protons (proton motive force) across the mitochondrial inner membrane via the process of chemiosmosis. While there is consensus that the proton gradient is generated by components of the electron transport chain, the...
Saved in:
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-01-01
|
| Series: | Biomolecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-273X/15/1/87 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832588932065263616 |
|---|---|
| author | Ramin M. Farahani |
| author_facet | Ramin M. Farahani |
| author_sort | Ramin M. Farahani |
| collection | DOAJ |
| description | Mitochondrial ATP synthesis is driven by harnessing the electrochemical gradient of protons (proton motive force) across the mitochondrial inner membrane via the process of chemiosmosis. While there is consensus that the proton gradient is generated by components of the electron transport chain, the mechanism by which protons are supplied to ATP synthase remains controversial. As opposed to a global coupling model whereby protons diffuse into the intermembrane space, a localised coupling model predicts that protons remain closely associated with the lipid membrane prior to interaction with ATP synthase. Herein, a revised version of the chemiosmotic theory is proposed by introducing an RNA-based proton sink which aligns the release of sequestered protons to availability of ADP and Pi thereby maximising the efficiency of oxidative phosphorylation. |
| format | Article |
| id | doaj-art-c6189418a51c4d62af5c77a9aeb01732 |
| institution | Kabale University |
| issn | 2218-273X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj-art-c6189418a51c4d62af5c77a9aeb017322025-01-24T13:25:07ZengMDPI AGBiomolecules2218-273X2025-01-011518710.3390/biom15010087An Addendum to the Chemiosmotic Theory of Mitochondrial Activity: The Role of RNA as a Proton SinkRamin M. Farahani0School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2006, AustraliaMitochondrial ATP synthesis is driven by harnessing the electrochemical gradient of protons (proton motive force) across the mitochondrial inner membrane via the process of chemiosmosis. While there is consensus that the proton gradient is generated by components of the electron transport chain, the mechanism by which protons are supplied to ATP synthase remains controversial. As opposed to a global coupling model whereby protons diffuse into the intermembrane space, a localised coupling model predicts that protons remain closely associated with the lipid membrane prior to interaction with ATP synthase. Herein, a revised version of the chemiosmotic theory is proposed by introducing an RNA-based proton sink which aligns the release of sequestered protons to availability of ADP and Pi thereby maximising the efficiency of oxidative phosphorylation.https://www.mdpi.com/2218-273X/15/1/87chemiosmosisproton motive forceproton sinkRNA |
| spellingShingle | Ramin M. Farahani An Addendum to the Chemiosmotic Theory of Mitochondrial Activity: The Role of RNA as a Proton Sink Biomolecules chemiosmosis proton motive force proton sink RNA |
| title | An Addendum to the Chemiosmotic Theory of Mitochondrial Activity: The Role of RNA as a Proton Sink |
| title_full | An Addendum to the Chemiosmotic Theory of Mitochondrial Activity: The Role of RNA as a Proton Sink |
| title_fullStr | An Addendum to the Chemiosmotic Theory of Mitochondrial Activity: The Role of RNA as a Proton Sink |
| title_full_unstemmed | An Addendum to the Chemiosmotic Theory of Mitochondrial Activity: The Role of RNA as a Proton Sink |
| title_short | An Addendum to the Chemiosmotic Theory of Mitochondrial Activity: The Role of RNA as a Proton Sink |
| title_sort | addendum to the chemiosmotic theory of mitochondrial activity the role of rna as a proton sink |
| topic | chemiosmosis proton motive force proton sink RNA |
| url | https://www.mdpi.com/2218-273X/15/1/87 |
| work_keys_str_mv | AT raminmfarahani anaddendumtothechemiosmotictheoryofmitochondrialactivitytheroleofrnaasaprotonsink AT raminmfarahani addendumtothechemiosmotictheoryofmitochondrialactivitytheroleofrnaasaprotonsink |