Changes of eye’s functions among patients with age-related macular degeneration during the use of vitamin D medications
Aim. To increase the effectiveness of the treatment of age-related macular degeneration (AMD), dry form, in postmenopausal women by determining the level of serum vitamin D and correcting its deficiency. Materials and methods. The study was conducted on the basis of the Department of Ophthalmolog...
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Zaporizhzhia State Medical and Pharmaceutical University
2024-09-01
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| Series: | Сучасні медичні технології |
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| Online Access: | https://medtech.mphu.edu.ua/article/view/306466/304028 |
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| author | T. M. Komarova O. P. Vitovska Yu. I. Komisarenko Sibylle K. Scholtz |
| author_facet | T. M. Komarova O. P. Vitovska Yu. I. Komisarenko Sibylle K. Scholtz |
| author_sort | T. M. Komarova |
| collection | DOAJ |
| description | Aim. To increase the effectiveness of the treatment of age-related macular degeneration (AMD), dry form, in postmenopausal women by determining the level of serum vitamin D and correcting its deficiency.
Materials and methods. The study was conducted on the basis of the Department of Ophthalmology at Bogomolets National Medical University, was prospective, case-control, included 88 women (88 eyes) aged 72.0 ± 10.1 years, who were divided into 2 groups: control group – 20 patients (20 eyes) without AMD and study group – 68 patients (68 eyes) with AMD, dry form.
Results. Supplemental vitamin D did not significantly improve visual acuity, but slowed the deterioration of contrast sensitivity. Deficiency of vitamin D is associated with lower visual acuity, negatively affects contrast sensitivity, more strongly than its insufficiency. The results of the treatment in the AREDS-2 + vitamin D group after 12 months showed a probable double increase in the content of 25(OH)D in patients with AMD, dry form (p < 0.05). Visual acuity after 12 months decreased by 7.56 % (from 0.19 ± 0.06 to 0.20 ± 0.06) in women who took only AREDS-2 drugs, and by 6.78 % (from 0.18 ± 0.07 to 0.19 ± 0.08) in the group where vitamin D medications were additionally prescribed (p > 0.05). Logarithmic indicators of contrast sensitivity after treatment had a slight negative trend in both groups, decreased by 2.80 % in women in the AREDS-2 group, and by 2.25 % in women who additionally took vitamin D medications (p > 0.05).
Conclusions. Irreversible vision loss is a global problem with both medical and socioeconomic consequences. Age-related macular degeneration is one of the main diseases that lead to blindness, especially in people over 50 years old. Additional prescription of vitamin D to AREDS-2 may be beneficial in slowing the progression of AMD. Further studies are needed to confirm these results. |
| format | Article |
| id | doaj-art-c612c3d4807845b191e23a9b23f46308 |
| institution | Kabale University |
| issn | 2072-9367 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | Zaporizhzhia State Medical and Pharmaceutical University |
| record_format | Article |
| series | Сучасні медичні технології |
| spelling | doaj-art-c612c3d4807845b191e23a9b23f463082025-08-20T03:24:47ZengZaporizhzhia State Medical and Pharmaceutical UniversityСучасні медичні технології2072-93672024-09-01163190196https://doi.org/10.14739/mmt.2024.3.306466Changes of eye’s functions among patients with age-related macular degeneration during the use of vitamin D medicationsT. M. Komarova0https://orcid.org/0000-0002-7263-4067O. P. Vitovska1https://orcid.org/0000-0002-5786-5166Yu. I. Komisarenko2https://orcid.org/0000-0001-9912-4879Sibylle K. Scholtz3https://orcid.org/0000-0001-7826-7416Bogomolets National Medical University, Kyiv, UkraineBogomolets National Medical University, Kyiv, UkraineBogomolets National Medical University, Kyiv, UkraineUniversität des Saarlandes, Homburg, GermanyAim. To increase the effectiveness of the treatment of age-related macular degeneration (AMD), dry form, in postmenopausal women by determining the level of serum vitamin D and correcting its deficiency. Materials and methods. The study was conducted on the basis of the Department of Ophthalmology at Bogomolets National Medical University, was prospective, case-control, included 88 women (88 eyes) aged 72.0 ± 10.1 years, who were divided into 2 groups: control group – 20 patients (20 eyes) without AMD and study group – 68 patients (68 eyes) with AMD, dry form. Results. Supplemental vitamin D did not significantly improve visual acuity, but slowed the deterioration of contrast sensitivity. Deficiency of vitamin D is associated with lower visual acuity, negatively affects contrast sensitivity, more strongly than its insufficiency. The results of the treatment in the AREDS-2 + vitamin D group after 12 months showed a probable double increase in the content of 25(OH)D in patients with AMD, dry form (p < 0.05). Visual acuity after 12 months decreased by 7.56 % (from 0.19 ± 0.06 to 0.20 ± 0.06) in women who took only AREDS-2 drugs, and by 6.78 % (from 0.18 ± 0.07 to 0.19 ± 0.08) in the group where vitamin D medications were additionally prescribed (p > 0.05). Logarithmic indicators of contrast sensitivity after treatment had a slight negative trend in both groups, decreased by 2.80 % in women in the AREDS-2 group, and by 2.25 % in women who additionally took vitamin D medications (p > 0.05). Conclusions. Irreversible vision loss is a global problem with both medical and socioeconomic consequences. Age-related macular degeneration is one of the main diseases that lead to blindness, especially in people over 50 years old. Additional prescription of vitamin D to AREDS-2 may be beneficial in slowing the progression of AMD. Further studies are needed to confirm these results.https://medtech.mphu.edu.ua/article/view/306466/304028age-related macular degenerationvitamin dvisual acuitycontrast sensitivity |
| spellingShingle | T. M. Komarova O. P. Vitovska Yu. I. Komisarenko Sibylle K. Scholtz Changes of eye’s functions among patients with age-related macular degeneration during the use of vitamin D medications Сучасні медичні технології age-related macular degeneration vitamin d visual acuity contrast sensitivity |
| title | Changes of eye’s functions among patients with age-related macular degeneration during the use of vitamin D medications |
| title_full | Changes of eye’s functions among patients with age-related macular degeneration during the use of vitamin D medications |
| title_fullStr | Changes of eye’s functions among patients with age-related macular degeneration during the use of vitamin D medications |
| title_full_unstemmed | Changes of eye’s functions among patients with age-related macular degeneration during the use of vitamin D medications |
| title_short | Changes of eye’s functions among patients with age-related macular degeneration during the use of vitamin D medications |
| title_sort | changes of eye s functions among patients with age related macular degeneration during the use of vitamin d medications |
| topic | age-related macular degeneration vitamin d visual acuity contrast sensitivity |
| url | https://medtech.mphu.edu.ua/article/view/306466/304028 |
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