Pioneering the use of micro-biomarkers in oral cancer detection
This critique analyzes the role of dietary habits on the vigorous field of oral microbiome studies and the treatment of oral cancer. It brings into light the multi-system interaction between the oral microbiota which not only look at the known pathogenic bacteria such as Porphyromonas gingivalis and...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-06-01
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| Series: | Oral Oncology Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772906024002589 |
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| author | Namrutha D Shekar L. Kayal N. Aravindha Babu Mukesh Kumar Dharmalingam Jothinathan Iadalin Ryntathiang |
| author_facet | Namrutha D Shekar L. Kayal N. Aravindha Babu Mukesh Kumar Dharmalingam Jothinathan Iadalin Ryntathiang |
| author_sort | Namrutha D Shekar |
| collection | DOAJ |
| description | This critique analyzes the role of dietary habits on the vigorous field of oral microbiome studies and the treatment of oral cancer. It brings into light the multi-system interaction between the oral microbiota which not only look at the known pathogenic bacteria such as Porphyromonas gingivalis and Fusobacterium nucleatum but the overall mechanism by which oral cancer develops. Molecular markers that microbes leave behind while colonizing a cancerous site may serve as windows into early diagnosis and prevention. Two examples of these are Corynebacterium and Fusobacterium. In reverse, though, the sampling inconsistency and limited picture of the interactions between microbes remain the main obstacles. Therefore, this review underlines the position of omics technology which helps us understand the role of microbiome and possibly its contribution in cancer development. Also, these studies should be conducted for the long term as it is expected to produce a comprehensive view. On the other hand, it scrutinizes formulation and application of microbiota stabilizers, such as prebiotics and probiotics in individualized anticancer therapy. On a positive side, the implication about this review is that oral microbial dysbiosis together with microbial biomarkers play a pivotal role and although the mechanism of disease is clearly depicted, consequently, it paves a way for patient-centered treatment approaches. |
| format | Article |
| id | doaj-art-c611ec842bf64f23b21514cdb7856e45 |
| institution | Kabale University |
| issn | 2772-9060 |
| language | English |
| publishDate | 2024-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Oral Oncology Reports |
| spelling | doaj-art-c611ec842bf64f23b21514cdb7856e452025-01-09T06:16:09ZengElsevierOral Oncology Reports2772-90602024-06-0110100412Pioneering the use of micro-biomarkers in oral cancer detectionNamrutha D Shekar0L. Kayal1N. Aravindha Babu2Mukesh Kumar Dharmalingam Jothinathan3Iadalin Ryntathiang4Centre for Global Health Research, Saveetha Medical College and Hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai, IndiaGovt.Stanley Medical College, The TN DR MGR Medical University, Chennai, 600001, IndiaDepartment of Oral Pathology and Microbiology, Sree Balaji Dental College and Hospital, Bharath Institute of Higher Education and Research (BIHER), Bharath University, Chennai, Tamil Nadu, IndiaCorresponding author; Centre for Global Health Research, Saveetha Medical College and Hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai, IndiaCentre for Global Health Research, Saveetha Medical College and Hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai, IndiaThis critique analyzes the role of dietary habits on the vigorous field of oral microbiome studies and the treatment of oral cancer. It brings into light the multi-system interaction between the oral microbiota which not only look at the known pathogenic bacteria such as Porphyromonas gingivalis and Fusobacterium nucleatum but the overall mechanism by which oral cancer develops. Molecular markers that microbes leave behind while colonizing a cancerous site may serve as windows into early diagnosis and prevention. Two examples of these are Corynebacterium and Fusobacterium. In reverse, though, the sampling inconsistency and limited picture of the interactions between microbes remain the main obstacles. Therefore, this review underlines the position of omics technology which helps us understand the role of microbiome and possibly its contribution in cancer development. Also, these studies should be conducted for the long term as it is expected to produce a comprehensive view. On the other hand, it scrutinizes formulation and application of microbiota stabilizers, such as prebiotics and probiotics in individualized anticancer therapy. On a positive side, the implication about this review is that oral microbial dysbiosis together with microbial biomarkers play a pivotal role and although the mechanism of disease is clearly depicted, consequently, it paves a way for patient-centered treatment approaches.http://www.sciencedirect.com/science/article/pii/S2772906024002589Micro-biomarkersOral cancerEarly detectionOral dysbiosis |
| spellingShingle | Namrutha D Shekar L. Kayal N. Aravindha Babu Mukesh Kumar Dharmalingam Jothinathan Iadalin Ryntathiang Pioneering the use of micro-biomarkers in oral cancer detection Oral Oncology Reports Micro-biomarkers Oral cancer Early detection Oral dysbiosis |
| title | Pioneering the use of micro-biomarkers in oral cancer detection |
| title_full | Pioneering the use of micro-biomarkers in oral cancer detection |
| title_fullStr | Pioneering the use of micro-biomarkers in oral cancer detection |
| title_full_unstemmed | Pioneering the use of micro-biomarkers in oral cancer detection |
| title_short | Pioneering the use of micro-biomarkers in oral cancer detection |
| title_sort | pioneering the use of micro biomarkers in oral cancer detection |
| topic | Micro-biomarkers Oral cancer Early detection Oral dysbiosis |
| url | http://www.sciencedirect.com/science/article/pii/S2772906024002589 |
| work_keys_str_mv | AT namruthadshekar pioneeringtheuseofmicrobiomarkersinoralcancerdetection AT lkayal pioneeringtheuseofmicrobiomarkersinoralcancerdetection AT naravindhababu pioneeringtheuseofmicrobiomarkersinoralcancerdetection AT mukeshkumardharmalingamjothinathan pioneeringtheuseofmicrobiomarkersinoralcancerdetection AT iadalinryntathiang pioneeringtheuseofmicrobiomarkersinoralcancerdetection |