Insights Into Health-Related Quality of Life of Kidney Transplant Recipients: A Narrative Review of Associated Factors
Life expectancy and graft survival continue to improve after transplantation. However, improved posttransplant clinical outcomes do not necessarily translate into improved health-related quality of life (HRQoL). Therefore, there is an increased focus on HRQoL in kidney transplant recipients (KTRs)....
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| Format: | Article |
| Language: | English |
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Elsevier
2025-05-01
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| Series: | Kidney Medicine |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590059525000226 |
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| author | Tim J. Knobbe Daan Kremer Ute Bültmann Coby Annema Gerjan Navis Stefan P. Berger Stephan J.L. Bakker Yvette Meuleman |
| author_facet | Tim J. Knobbe Daan Kremer Ute Bültmann Coby Annema Gerjan Navis Stefan P. Berger Stephan J.L. Bakker Yvette Meuleman |
| author_sort | Tim J. Knobbe |
| collection | DOAJ |
| description | Life expectancy and graft survival continue to improve after transplantation. However, improved posttransplant clinical outcomes do not necessarily translate into improved health-related quality of life (HRQoL). Therefore, there is an increased focus on HRQoL in kidney transplant recipients (KTRs). The HRQoL of KTRs is worse than that of the general population, but interventions that improve HRQoL in KTRs are scarce, and health care professionals in nephrology care do not routinely address HRQoL. To improve HRQoL, it is essential to understand which factors play a role in HRQoL and to pinpoint areas for intervention. This narrative review maps the concept of HRQoL within the KTR population and provides a comprehensive overview of factors associated with posttransplant HRQoL. The results are structured using an easy-to-understand conceptual model of HRQoL, which is instrumental for understanding how HRQoL is constituted of many clinical and nonclinical factors. We conclude that symptom burden among KTRs is high, which is likely a key driver of the limited HRQoL in this population. Moreover, myriad other clinical and nonclinical factors are associated with HRQoL, but the majority of the evidence is observational. |
| format | Article |
| id | doaj-art-c610cea3c42d4cbeb57e73b8a74e1141 |
| institution | DOAJ |
| issn | 2590-0595 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Kidney Medicine |
| spelling | doaj-art-c610cea3c42d4cbeb57e73b8a74e11412025-08-20T02:51:38ZengElsevierKidney Medicine2590-05952025-05-017510098610.1016/j.xkme.2025.100986Insights Into Health-Related Quality of Life of Kidney Transplant Recipients: A Narrative Review of Associated FactorsTim J. Knobbe0Daan Kremer1Ute Bültmann2Coby Annema3Gerjan Navis4Stefan P. Berger5Stephan J.L. Bakker6Yvette Meuleman7Division of Nephrology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands; Address for Correspondence: Tim J. Knobbe, Division of Nephrology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Hanzeplein 1, P.O. Box 30.001, 9713 GZ Groningen, The Netherlands.Division of Nephrology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The NetherlandsCommunity and Occupational Medicine, Department of Health Sciences, University Medical Center Groningen, University of Groningen, Groningen, The NetherlandsSection of Nursing Science, Department of Health Sciences, University Medical Center Groningen, University of Groningen, Groningen, The NetherlandsDivision of Nephrology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The NetherlandsDivision of Nephrology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The NetherlandsDivision of Nephrology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The NetherlandsDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden, NetherlandsLife expectancy and graft survival continue to improve after transplantation. However, improved posttransplant clinical outcomes do not necessarily translate into improved health-related quality of life (HRQoL). Therefore, there is an increased focus on HRQoL in kidney transplant recipients (KTRs). The HRQoL of KTRs is worse than that of the general population, but interventions that improve HRQoL in KTRs are scarce, and health care professionals in nephrology care do not routinely address HRQoL. To improve HRQoL, it is essential to understand which factors play a role in HRQoL and to pinpoint areas for intervention. This narrative review maps the concept of HRQoL within the KTR population and provides a comprehensive overview of factors associated with posttransplant HRQoL. The results are structured using an easy-to-understand conceptual model of HRQoL, which is instrumental for understanding how HRQoL is constituted of many clinical and nonclinical factors. We conclude that symptom burden among KTRs is high, which is likely a key driver of the limited HRQoL in this population. Moreover, myriad other clinical and nonclinical factors are associated with HRQoL, but the majority of the evidence is observational.http://www.sciencedirect.com/science/article/pii/S2590059525000226 |
| spellingShingle | Tim J. Knobbe Daan Kremer Ute Bültmann Coby Annema Gerjan Navis Stefan P. Berger Stephan J.L. Bakker Yvette Meuleman Insights Into Health-Related Quality of Life of Kidney Transplant Recipients: A Narrative Review of Associated Factors Kidney Medicine |
| title | Insights Into Health-Related Quality of Life of Kidney Transplant Recipients: A Narrative Review of Associated Factors |
| title_full | Insights Into Health-Related Quality of Life of Kidney Transplant Recipients: A Narrative Review of Associated Factors |
| title_fullStr | Insights Into Health-Related Quality of Life of Kidney Transplant Recipients: A Narrative Review of Associated Factors |
| title_full_unstemmed | Insights Into Health-Related Quality of Life of Kidney Transplant Recipients: A Narrative Review of Associated Factors |
| title_short | Insights Into Health-Related Quality of Life of Kidney Transplant Recipients: A Narrative Review of Associated Factors |
| title_sort | insights into health related quality of life of kidney transplant recipients a narrative review of associated factors |
| url | http://www.sciencedirect.com/science/article/pii/S2590059525000226 |
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