Posterior Reversible Encephalopathy Syndrome due to Hypomagnesemia: A Case Report and Literature Review

Background. Hypomagnesemia can cause various unspecific neurological complications, which can lead to diagnostic confusion. One of these complications is the posterior reversible encephalopathy syndrome (PRES), which is extremely uncommon and has been reported only twice in the English-language lite...

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Main Authors: Mohamad Almoussa, Angelika Goertzen, Stephan Brauckmann, Barbara Fauser, Christoph W. Zimmermann
Format: Article
Language:English
Published: Wiley 2018-01-01
Series:Case Reports in Medicine
Online Access:http://dx.doi.org/10.1155/2018/1980638
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author Mohamad Almoussa
Angelika Goertzen
Stephan Brauckmann
Barbara Fauser
Christoph W. Zimmermann
author_facet Mohamad Almoussa
Angelika Goertzen
Stephan Brauckmann
Barbara Fauser
Christoph W. Zimmermann
author_sort Mohamad Almoussa
collection DOAJ
description Background. Hypomagnesemia can cause various unspecific neurological complications, which can lead to diagnostic confusion. One of these complications is the posterior reversible encephalopathy syndrome (PRES), which is extremely uncommon and has been reported only twice in the English-language literature. Case presentation. We report the case of a 60-year-old man who presented with PRES involving only the cerebellar hemispheres and associated with hypomagnesemia. After excluding all the other possible etiologies of PRES, we started magnesium replacement therapy, which led to a remarkable but fluctuating clinical and chemical improvement. A full recovery with no need for further supplementation was achieved only after discontinuation of a proton pump inhibitor. Conclusions. This case highlights the role of magnesium in the pathophysiology of PRES; thereby, underlying hypomagnesemia should be considered in every PRES case with unclear etiology.
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spelling doaj-art-c60f9aae073441ecabff833bc745e34f2025-02-03T06:14:03ZengWileyCase Reports in Medicine1687-96271687-96352018-01-01201810.1155/2018/19806381980638Posterior Reversible Encephalopathy Syndrome due to Hypomagnesemia: A Case Report and Literature ReviewMohamad Almoussa0Angelika Goertzen1Stephan Brauckmann2Barbara Fauser3Christoph W. Zimmermann4Department of Neurology, St. Josef Hospital, The Academic Hospital of Duisburg-Essen University, Mülheimer Strasse 83, 46045 Oberhausen, GermanyDepartment of Neurology, St. Josef Hospital, The Academic Hospital of Duisburg-Essen University, Mülheimer Strasse 83, 46045 Oberhausen, GermanyDepartment of Neurology, St. Josef Hospital, The Academic Hospital of Duisburg-Essen University, Mülheimer Strasse 83, 46045 Oberhausen, GermanyDepartment of Neurology, St. Josef Hospital, The Academic Hospital of Duisburg-Essen University, Mülheimer Strasse 83, 46045 Oberhausen, GermanyDepartment of Neurology, St. Josef Hospital, The Academic Hospital of Duisburg-Essen University, Mülheimer Strasse 83, 46045 Oberhausen, GermanyBackground. Hypomagnesemia can cause various unspecific neurological complications, which can lead to diagnostic confusion. One of these complications is the posterior reversible encephalopathy syndrome (PRES), which is extremely uncommon and has been reported only twice in the English-language literature. Case presentation. We report the case of a 60-year-old man who presented with PRES involving only the cerebellar hemispheres and associated with hypomagnesemia. After excluding all the other possible etiologies of PRES, we started magnesium replacement therapy, which led to a remarkable but fluctuating clinical and chemical improvement. A full recovery with no need for further supplementation was achieved only after discontinuation of a proton pump inhibitor. Conclusions. This case highlights the role of magnesium in the pathophysiology of PRES; thereby, underlying hypomagnesemia should be considered in every PRES case with unclear etiology.http://dx.doi.org/10.1155/2018/1980638
spellingShingle Mohamad Almoussa
Angelika Goertzen
Stephan Brauckmann
Barbara Fauser
Christoph W. Zimmermann
Posterior Reversible Encephalopathy Syndrome due to Hypomagnesemia: A Case Report and Literature Review
Case Reports in Medicine
title Posterior Reversible Encephalopathy Syndrome due to Hypomagnesemia: A Case Report and Literature Review
title_full Posterior Reversible Encephalopathy Syndrome due to Hypomagnesemia: A Case Report and Literature Review
title_fullStr Posterior Reversible Encephalopathy Syndrome due to Hypomagnesemia: A Case Report and Literature Review
title_full_unstemmed Posterior Reversible Encephalopathy Syndrome due to Hypomagnesemia: A Case Report and Literature Review
title_short Posterior Reversible Encephalopathy Syndrome due to Hypomagnesemia: A Case Report and Literature Review
title_sort posterior reversible encephalopathy syndrome due to hypomagnesemia a case report and literature review
url http://dx.doi.org/10.1155/2018/1980638
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