Cyclodextrin Inclusion Complexes with Hydrocortisone-Type Corticosteroids
The hydrocortisone-type corticosteroid (HTC) group includes valuable active pharmaceutical ingredients (APIs) such as hydrocortisone, hydrocortisone acetate, cortisone acetate, tixocortol pivalate, prednisolone, methylprednisolone, and prednisone. Unfortunately, those APIs are characterized by low s...
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2024-12-01
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| author | Aleksandra Kowalska Łukasz Szeleszczuk |
| author_facet | Aleksandra Kowalska Łukasz Szeleszczuk |
| author_sort | Aleksandra Kowalska |
| collection | DOAJ |
| description | The hydrocortisone-type corticosteroid (HTC) group includes valuable active pharmaceutical ingredients (APIs) such as hydrocortisone, hydrocortisone acetate, cortisone acetate, tixocortol pivalate, prednisolone, methylprednisolone, and prednisone. Unfortunately, those APIs are characterized by low solubility, which hampers their application and reduces their therapeutic efficacy. The low polarity of HTC molecules allows them to form inclusion complexes with various cyclodextrins (CDs); however, as shown in this review, the type of applied CDs has a major impact on the final properties of the formed complex. HTC–CD complexes have been routinely used for over 40 years to achieve various aims. Most frequently, CDs have been utilized as HTC solubilizers and absorption enhancers in pharmaceutical formulations, as well as for separation and analysis by chromatographic and electrophoretic methods. This article reviews the studies describing the synthesis as well as the biological, physiochemical, and structural properties of the inclusion complexes formed between HTC and various cyclodextrins. |
| format | Article |
| id | doaj-art-c60dd6f94d73494895caea077ad5eca1 |
| institution | Kabale University |
| issn | 1999-4923 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj-art-c60dd6f94d73494895caea077ad5eca12024-12-27T14:46:27ZengMDPI AGPharmaceutics1999-49232024-12-011612154410.3390/pharmaceutics16121544Cyclodextrin Inclusion Complexes with Hydrocortisone-Type CorticosteroidsAleksandra Kowalska0Łukasz Szeleszczuk1Department of Organic and Physical Chemistry, Faculty of Pharmacy, Medical University of Warsaw, Banacha 1 Str., 02-093 Warsaw, PolandDepartment of Organic and Physical Chemistry, Faculty of Pharmacy, Medical University of Warsaw, Banacha 1 Str., 02-093 Warsaw, PolandThe hydrocortisone-type corticosteroid (HTC) group includes valuable active pharmaceutical ingredients (APIs) such as hydrocortisone, hydrocortisone acetate, cortisone acetate, tixocortol pivalate, prednisolone, methylprednisolone, and prednisone. Unfortunately, those APIs are characterized by low solubility, which hampers their application and reduces their therapeutic efficacy. The low polarity of HTC molecules allows them to form inclusion complexes with various cyclodextrins (CDs); however, as shown in this review, the type of applied CDs has a major impact on the final properties of the formed complex. HTC–CD complexes have been routinely used for over 40 years to achieve various aims. Most frequently, CDs have been utilized as HTC solubilizers and absorption enhancers in pharmaceutical formulations, as well as for separation and analysis by chromatographic and electrophoretic methods. This article reviews the studies describing the synthesis as well as the biological, physiochemical, and structural properties of the inclusion complexes formed between HTC and various cyclodextrins.https://www.mdpi.com/1999-4923/16/12/1544cyclodextrininclusion complexcorticosteroidhydrocortisonecortisolCD |
| spellingShingle | Aleksandra Kowalska Łukasz Szeleszczuk Cyclodextrin Inclusion Complexes with Hydrocortisone-Type Corticosteroids Pharmaceutics cyclodextrin inclusion complex corticosteroid hydrocortisone cortisol CD |
| title | Cyclodextrin Inclusion Complexes with Hydrocortisone-Type Corticosteroids |
| title_full | Cyclodextrin Inclusion Complexes with Hydrocortisone-Type Corticosteroids |
| title_fullStr | Cyclodextrin Inclusion Complexes with Hydrocortisone-Type Corticosteroids |
| title_full_unstemmed | Cyclodextrin Inclusion Complexes with Hydrocortisone-Type Corticosteroids |
| title_short | Cyclodextrin Inclusion Complexes with Hydrocortisone-Type Corticosteroids |
| title_sort | cyclodextrin inclusion complexes with hydrocortisone type corticosteroids |
| topic | cyclodextrin inclusion complex corticosteroid hydrocortisone cortisol CD |
| url | https://www.mdpi.com/1999-4923/16/12/1544 |
| work_keys_str_mv | AT aleksandrakowalska cyclodextrininclusioncomplexeswithhydrocortisonetypecorticosteroids AT łukaszszeleszczuk cyclodextrininclusioncomplexeswithhydrocortisonetypecorticosteroids |