Utilization of Glycosaminoglycans/Proteoglycans as Carriers for Targeted Therapy Delivery
The outcome of patients with cancer has improved significantly in the past decade with the incorporation of drugs targeting cell surface adhesive receptors, receptor tyrosine kinases, and modulation of several molecules of extracellular matrices (ECMs), the complex composite of collagens, glycoprote...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
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| Series: | International Journal of Cell Biology |
| Online Access: | http://dx.doi.org/10.1155/2015/537560 |
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| _version_ | 1849686395239530496 |
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| author | Suniti Misra Vincent C. Hascall Ilia Atanelishvili Ricardo Moreno Rodriguez Roger R. Markwald Shibnath Ghatak |
| author_facet | Suniti Misra Vincent C. Hascall Ilia Atanelishvili Ricardo Moreno Rodriguez Roger R. Markwald Shibnath Ghatak |
| author_sort | Suniti Misra |
| collection | DOAJ |
| description | The outcome of patients with cancer has improved significantly in the past decade with the incorporation of drugs targeting cell surface adhesive receptors, receptor tyrosine kinases, and modulation of several molecules of extracellular matrices (ECMs), the complex composite of collagens, glycoproteins, proteoglycans, and glycosaminoglycans that dictates tissue architecture. Cancer tissue invasive processes progress by various oncogenic strategies, including interfering with ECM molecules and their interactions with invasive cells. In this review, we describe how the ECM components, proteoglycans and glycosaminoglycans, influence tumor cell signaling. In particular this review describes how the glycosaminoglycan hyaluronan (HA) and its major receptor CD44 impact invasive behavior of tumor cells, and provides useful insight when designing new therapeutic strategies in the treatment of cancer. |
| format | Article |
| id | doaj-art-c607f91182aa4a09a0f6a5c192957657 |
| institution | DOAJ |
| issn | 1687-8876 1687-8884 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Cell Biology |
| spelling | doaj-art-c607f91182aa4a09a0f6a5c1929576572025-08-20T03:22:42ZengWileyInternational Journal of Cell Biology1687-88761687-88842015-01-01201510.1155/2015/537560537560Utilization of Glycosaminoglycans/Proteoglycans as Carriers for Targeted Therapy DeliverySuniti Misra0Vincent C. Hascall1Ilia Atanelishvili2Ricardo Moreno Rodriguez3Roger R. Markwald4Shibnath Ghatak5Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC 29425, USADepartment of Biomedical Engineering/ND20, Cleveland Clinic, Cleveland, OH, USADivision of Rheumatology & Immunology, Department of Medicine, Medical University of South Carolina, 114 Doughty Street, Charleston, SC 29425, USADepartment of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC 29425, USADepartment of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC 29425, USADepartment of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC 29425, USAThe outcome of patients with cancer has improved significantly in the past decade with the incorporation of drugs targeting cell surface adhesive receptors, receptor tyrosine kinases, and modulation of several molecules of extracellular matrices (ECMs), the complex composite of collagens, glycoproteins, proteoglycans, and glycosaminoglycans that dictates tissue architecture. Cancer tissue invasive processes progress by various oncogenic strategies, including interfering with ECM molecules and their interactions with invasive cells. In this review, we describe how the ECM components, proteoglycans and glycosaminoglycans, influence tumor cell signaling. In particular this review describes how the glycosaminoglycan hyaluronan (HA) and its major receptor CD44 impact invasive behavior of tumor cells, and provides useful insight when designing new therapeutic strategies in the treatment of cancer.http://dx.doi.org/10.1155/2015/537560 |
| spellingShingle | Suniti Misra Vincent C. Hascall Ilia Atanelishvili Ricardo Moreno Rodriguez Roger R. Markwald Shibnath Ghatak Utilization of Glycosaminoglycans/Proteoglycans as Carriers for Targeted Therapy Delivery International Journal of Cell Biology |
| title | Utilization of Glycosaminoglycans/Proteoglycans as Carriers for Targeted Therapy Delivery |
| title_full | Utilization of Glycosaminoglycans/Proteoglycans as Carriers for Targeted Therapy Delivery |
| title_fullStr | Utilization of Glycosaminoglycans/Proteoglycans as Carriers for Targeted Therapy Delivery |
| title_full_unstemmed | Utilization of Glycosaminoglycans/Proteoglycans as Carriers for Targeted Therapy Delivery |
| title_short | Utilization of Glycosaminoglycans/Proteoglycans as Carriers for Targeted Therapy Delivery |
| title_sort | utilization of glycosaminoglycans proteoglycans as carriers for targeted therapy delivery |
| url | http://dx.doi.org/10.1155/2015/537560 |
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