Human Septal Cartilage Tissue Engineering: Current Methodologies and Future Directions
Nasal septal cartilage tissue engineering is a promising and dynamic field with the potential to provide surgical options for patients with complex reconstruction needs and mitigate the risks incurred by other tissue sources. Developments in cell source selection, cell expansion, scaffold creation,...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-11-01
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| Series: | Bioengineering |
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| Online Access: | https://www.mdpi.com/2306-5354/11/11/1123 |
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| author | Tammy B. Pham Robert L. Sah Koichi Masuda Deborah Watson |
| author_facet | Tammy B. Pham Robert L. Sah Koichi Masuda Deborah Watson |
| author_sort | Tammy B. Pham |
| collection | DOAJ |
| description | Nasal septal cartilage tissue engineering is a promising and dynamic field with the potential to provide surgical options for patients with complex reconstruction needs and mitigate the risks incurred by other tissue sources. Developments in cell source selection, cell expansion, scaffold creation, and three-dimensional (3D) bioprinting have advanced the field in recent years. The usage of medicinal signaling cells and nasal chondroprogenitor cells can enhance chondrocyte proliferation, stimulate chondrocyte growth, and limit chondrocyte dedifferentiate. New scaffolds combined with recent innovations in 3D bioprinting have allowed for the creation of more durable and customizable constructs. Future developments may increase technical accessibility and manufacturability, and lower costs, to help incorporate these methods into pre-clinical studies and clinical applications of septal cartilage tissue engineering. |
| format | Article |
| id | doaj-art-c606e0bdc7d84e9e80289815d4e60f61 |
| institution | OA Journals |
| issn | 2306-5354 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Bioengineering |
| spelling | doaj-art-c606e0bdc7d84e9e80289815d4e60f612025-08-20T02:08:12ZengMDPI AGBioengineering2306-53542024-11-011111112310.3390/bioengineering11111123Human Septal Cartilage Tissue Engineering: Current Methodologies and Future DirectionsTammy B. Pham0Robert L. Sah1Koichi Masuda2Deborah Watson3Department of Otolaryngology-Head and Neck Surgery, UC San Diego Health, La Jolla, CA 92093, USAShu Chien-Gene Lay Department of Bioengineering, UC San Diego Jacobs School of Engineering, La Jolla, CA 92093, USADepartment of Orthopedic Surgery, UC San Diego Health, La Jolla, CA 92093, USADepartment of Otolaryngology-Head and Neck Surgery, UC San Diego Health, La Jolla, CA 92093, USANasal septal cartilage tissue engineering is a promising and dynamic field with the potential to provide surgical options for patients with complex reconstruction needs and mitigate the risks incurred by other tissue sources. Developments in cell source selection, cell expansion, scaffold creation, and three-dimensional (3D) bioprinting have advanced the field in recent years. The usage of medicinal signaling cells and nasal chondroprogenitor cells can enhance chondrocyte proliferation, stimulate chondrocyte growth, and limit chondrocyte dedifferentiate. New scaffolds combined with recent innovations in 3D bioprinting have allowed for the creation of more durable and customizable constructs. Future developments may increase technical accessibility and manufacturability, and lower costs, to help incorporate these methods into pre-clinical studies and clinical applications of septal cartilage tissue engineering.https://www.mdpi.com/2306-5354/11/11/1123nasal septal cartilagecartilage tissue engineeringcartilage scaffoldsbioink3D printed cartilage |
| spellingShingle | Tammy B. Pham Robert L. Sah Koichi Masuda Deborah Watson Human Septal Cartilage Tissue Engineering: Current Methodologies and Future Directions Bioengineering nasal septal cartilage cartilage tissue engineering cartilage scaffolds bioink 3D printed cartilage |
| title | Human Septal Cartilage Tissue Engineering: Current Methodologies and Future Directions |
| title_full | Human Septal Cartilage Tissue Engineering: Current Methodologies and Future Directions |
| title_fullStr | Human Septal Cartilage Tissue Engineering: Current Methodologies and Future Directions |
| title_full_unstemmed | Human Septal Cartilage Tissue Engineering: Current Methodologies and Future Directions |
| title_short | Human Septal Cartilage Tissue Engineering: Current Methodologies and Future Directions |
| title_sort | human septal cartilage tissue engineering current methodologies and future directions |
| topic | nasal septal cartilage cartilage tissue engineering cartilage scaffolds bioink 3D printed cartilage |
| url | https://www.mdpi.com/2306-5354/11/11/1123 |
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