Association between Sleep Traits and Lung Cancer: A Mendelian Randomization Study
Multidimensional sleep trait, which is related to circadian rhythms closely, affects some cancers predominantly, while the relationship between sleep and lung cancer is rarely illustrated. We aimed to investigate whether sleep is causally associated with risk of lung cancer, through a two-sample Men...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2021/1893882 |
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| author | Jie Wang Haibo Tang Yumei Duan Siyu Yang Jian An |
| author_facet | Jie Wang Haibo Tang Yumei Duan Siyu Yang Jian An |
| author_sort | Jie Wang |
| collection | DOAJ |
| description | Multidimensional sleep trait, which is related to circadian rhythms closely, affects some cancers predominantly, while the relationship between sleep and lung cancer is rarely illustrated. We aimed to investigate whether sleep is causally associated with risk of lung cancer, through a two-sample Mendelian randomization study. The main analysis used publicly available GWAS summary data from two large consortia (UK Biobank and International Lung Cancer Consortium). Two-sample Mendelian randomization (MR) analysis was used to examine whether chronotype, getting up in the morning, sleep duration, nap during the day, or sleeplessness was causally associated with the risk of lung cancer. Additionally, multivariate MR analysis was also conducted to estimate the direct effects between sleep traits and lung cancer risks independent of smoking status including pack years of smoking or current tobacco smoking. There was no evidence of causal association between chronotype, getting up in the morning, or nap during the day and lung cancer. Sleeplessness was associated with higher risk of lung adenocarcinoma (odds ratio 5.75, 95% confidence intervals 2.12-15.65), while sleep duration played a protective role in lung cancer (0.46, 0.26-0.83). In multivariate MR analysis, sleeplessness and sleep duration remained to have similar results. In conclusion, we found robust evidence for effect of sleeplessness on lung adenocarcinoma risk and inconsistent evidence for a protective effect of sleep duration on lung cancer risk. |
| format | Article |
| id | doaj-art-c6062acd274e49b19fea0a321015dc0e |
| institution | OA Journals |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-c6062acd274e49b19fea0a321015dc0e2025-08-20T02:18:39ZengWileyJournal of Immunology Research2314-88612314-71562021-01-01202110.1155/2021/18938821893882Association between Sleep Traits and Lung Cancer: A Mendelian Randomization StudyJie Wang0Haibo Tang1Yumei Duan2Siyu Yang3Jian An4Health Management Center, The Third Xiangya Hospital, Central South University, Changsha 410013, ChinaDepartment of Metabolic and Bariatric Surgery, The Third Xiangya Hospital, Central South University, Changsha 410013, ChinaDepartment of Pathology, Xiangya Hospital, Central South University, Changsha 410008, ChinaSuzhou Science and Technology Town Foreign Language School, ChinaDepartment of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha 410008, ChinaMultidimensional sleep trait, which is related to circadian rhythms closely, affects some cancers predominantly, while the relationship between sleep and lung cancer is rarely illustrated. We aimed to investigate whether sleep is causally associated with risk of lung cancer, through a two-sample Mendelian randomization study. The main analysis used publicly available GWAS summary data from two large consortia (UK Biobank and International Lung Cancer Consortium). Two-sample Mendelian randomization (MR) analysis was used to examine whether chronotype, getting up in the morning, sleep duration, nap during the day, or sleeplessness was causally associated with the risk of lung cancer. Additionally, multivariate MR analysis was also conducted to estimate the direct effects between sleep traits and lung cancer risks independent of smoking status including pack years of smoking or current tobacco smoking. There was no evidence of causal association between chronotype, getting up in the morning, or nap during the day and lung cancer. Sleeplessness was associated with higher risk of lung adenocarcinoma (odds ratio 5.75, 95% confidence intervals 2.12-15.65), while sleep duration played a protective role in lung cancer (0.46, 0.26-0.83). In multivariate MR analysis, sleeplessness and sleep duration remained to have similar results. In conclusion, we found robust evidence for effect of sleeplessness on lung adenocarcinoma risk and inconsistent evidence for a protective effect of sleep duration on lung cancer risk.http://dx.doi.org/10.1155/2021/1893882 |
| spellingShingle | Jie Wang Haibo Tang Yumei Duan Siyu Yang Jian An Association between Sleep Traits and Lung Cancer: A Mendelian Randomization Study Journal of Immunology Research |
| title | Association between Sleep Traits and Lung Cancer: A Mendelian Randomization Study |
| title_full | Association between Sleep Traits and Lung Cancer: A Mendelian Randomization Study |
| title_fullStr | Association between Sleep Traits and Lung Cancer: A Mendelian Randomization Study |
| title_full_unstemmed | Association between Sleep Traits and Lung Cancer: A Mendelian Randomization Study |
| title_short | Association between Sleep Traits and Lung Cancer: A Mendelian Randomization Study |
| title_sort | association between sleep traits and lung cancer a mendelian randomization study |
| url | http://dx.doi.org/10.1155/2021/1893882 |
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