The GLUT9 gene is associated with serum uric acid levels in Sardinia and Chianti cohorts.
High serum uric acid levels elevate pro-inflammatory-state gout crystal arthropathy and place individuals at high risk for cardiovascular morbidity and mortality. Genome-wide scans in the genetically isolated Sardinian population identified variants associated with serum uric acid levels as a quanti...
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Public Library of Science (PLoS)
2007-11-01
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| Series: | PLoS Genetics |
| Online Access: | https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.0030194&type=printable |
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| author | Siguang Li Serena Sanna Andrea Maschio Fabio Busonero Gianluca Usala Antonella Mulas Sandra Lai Mariano Dei Marco Orrù Giuseppe Albai Stefania Bandinelli David Schlessinger Edward Lakatta Angelo Scuteri Samer S Najjar Jack Guralnik Silvia Naitza Laura Crisponi Antonio Cao Gonçalo Abecasis Luigi Ferrucci Manuela Uda Wei-Min Chen Ramaiah Nagaraja |
| author_facet | Siguang Li Serena Sanna Andrea Maschio Fabio Busonero Gianluca Usala Antonella Mulas Sandra Lai Mariano Dei Marco Orrù Giuseppe Albai Stefania Bandinelli David Schlessinger Edward Lakatta Angelo Scuteri Samer S Najjar Jack Guralnik Silvia Naitza Laura Crisponi Antonio Cao Gonçalo Abecasis Luigi Ferrucci Manuela Uda Wei-Min Chen Ramaiah Nagaraja |
| author_sort | Siguang Li |
| collection | DOAJ |
| description | High serum uric acid levels elevate pro-inflammatory-state gout crystal arthropathy and place individuals at high risk for cardiovascular morbidity and mortality. Genome-wide scans in the genetically isolated Sardinian population identified variants associated with serum uric acid levels as a quantitative trait. They mapped within GLUT9, a Chromosome 4 glucose transporter gene predominantly expressed in liver and kidney. SNP rs6855911 showed the strongest association (p = 1.84 x 10(-16)), along with eight others (p = 7.75 x 10(-16) to 6.05 x 10(-11)). Individuals homozygous for the rare allele of rs6855911 (minor allele frequency = 0.26) had 0.6 mg/dl less uric acid than those homozygous for the common allele; the results were replicated in an unrelated cohort from Tuscany. Our results suggest that polymorphisms in GLUT9 could affect glucose metabolism and uric acid synthesis and/or renal reabsorption, influencing serum uric acid levels over a wide range of values. |
| format | Article |
| id | doaj-art-c60593e7ab224e6dadf50b9e691ab045 |
| institution | OA Journals |
| issn | 1553-7390 1553-7404 |
| language | English |
| publishDate | 2007-11-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Genetics |
| spelling | doaj-art-c60593e7ab224e6dadf50b9e691ab0452025-08-20T02:17:24ZengPublic Library of Science (PLoS)PLoS Genetics1553-73901553-74042007-11-01311e19410.1371/journal.pgen.0030194The GLUT9 gene is associated with serum uric acid levels in Sardinia and Chianti cohorts.Siguang LiSerena SannaAndrea MaschioFabio BusoneroGianluca UsalaAntonella MulasSandra LaiMariano DeiMarco OrrùGiuseppe AlbaiStefania BandinelliDavid SchlessingerEdward LakattaAngelo ScuteriSamer S NajjarJack GuralnikSilvia NaitzaLaura CrisponiAntonio CaoGonçalo AbecasisLuigi FerrucciManuela UdaWei-Min ChenRamaiah NagarajaHigh serum uric acid levels elevate pro-inflammatory-state gout crystal arthropathy and place individuals at high risk for cardiovascular morbidity and mortality. Genome-wide scans in the genetically isolated Sardinian population identified variants associated with serum uric acid levels as a quantitative trait. They mapped within GLUT9, a Chromosome 4 glucose transporter gene predominantly expressed in liver and kidney. SNP rs6855911 showed the strongest association (p = 1.84 x 10(-16)), along with eight others (p = 7.75 x 10(-16) to 6.05 x 10(-11)). Individuals homozygous for the rare allele of rs6855911 (minor allele frequency = 0.26) had 0.6 mg/dl less uric acid than those homozygous for the common allele; the results were replicated in an unrelated cohort from Tuscany. Our results suggest that polymorphisms in GLUT9 could affect glucose metabolism and uric acid synthesis and/or renal reabsorption, influencing serum uric acid levels over a wide range of values.https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.0030194&type=printable |
| spellingShingle | Siguang Li Serena Sanna Andrea Maschio Fabio Busonero Gianluca Usala Antonella Mulas Sandra Lai Mariano Dei Marco Orrù Giuseppe Albai Stefania Bandinelli David Schlessinger Edward Lakatta Angelo Scuteri Samer S Najjar Jack Guralnik Silvia Naitza Laura Crisponi Antonio Cao Gonçalo Abecasis Luigi Ferrucci Manuela Uda Wei-Min Chen Ramaiah Nagaraja The GLUT9 gene is associated with serum uric acid levels in Sardinia and Chianti cohorts. PLoS Genetics |
| title | The GLUT9 gene is associated with serum uric acid levels in Sardinia and Chianti cohorts. |
| title_full | The GLUT9 gene is associated with serum uric acid levels in Sardinia and Chianti cohorts. |
| title_fullStr | The GLUT9 gene is associated with serum uric acid levels in Sardinia and Chianti cohorts. |
| title_full_unstemmed | The GLUT9 gene is associated with serum uric acid levels in Sardinia and Chianti cohorts. |
| title_short | The GLUT9 gene is associated with serum uric acid levels in Sardinia and Chianti cohorts. |
| title_sort | glut9 gene is associated with serum uric acid levels in sardinia and chianti cohorts |
| url | https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.0030194&type=printable |
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