Reticulon Protein-1C: A New Hope in the Treatment of Different Neuronal Diseases
Reticulons (RTNs) are a group of membrane proteins localized on the ER and known to regulate ER structure and functions. Several studies have suggested that RTNs are involved in different important cellular functions such as changes in calcium homeostasis, ER-stress-mediated cell death, and autophag...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Cell Biology |
| Online Access: | http://dx.doi.org/10.1155/2012/651805 |
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| _version_ | 1849686393747406848 |
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| author | Federica Di Sano Mauro Piacentini |
| author_facet | Federica Di Sano Mauro Piacentini |
| author_sort | Federica Di Sano |
| collection | DOAJ |
| description | Reticulons (RTNs) are a group of membrane proteins localized on the ER and known to regulate ER structure and functions. Several studies have suggested that RTNs are involved in different important cellular functions such as changes in calcium homeostasis, ER-stress-mediated cell death, and autophagy. RTNs have been demonstrated to exert a cancer specific proapoptotic function via the interaction or the modulation of specific proteins. Reticulons have also been implicated in different signaling pathways which are at the basis of the pathogenesis of several neurodegenerative diseases. In this paper we discuss the accumulating evidence identifying RTN-1C protein as a promising target in the treatment of different pathologies such as cancer or neurodegenerative disorders. |
| format | Article |
| id | doaj-art-c6044e7ed6794b24a966ea3029bf07ac |
| institution | DOAJ |
| issn | 1687-8876 1687-8884 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Cell Biology |
| spelling | doaj-art-c6044e7ed6794b24a966ea3029bf07ac2025-08-20T03:22:42ZengWileyInternational Journal of Cell Biology1687-88761687-88842012-01-01201210.1155/2012/651805651805Reticulon Protein-1C: A New Hope in the Treatment of Different Neuronal DiseasesFederica Di Sano0Mauro Piacentini1Department of Biology, University of Rome “Tor Vergata”, Via della Ricerca Scientifica, 00133 Rome, ItalyDepartment of Biology, University of Rome “Tor Vergata”, Via della Ricerca Scientifica, 00133 Rome, ItalyReticulons (RTNs) are a group of membrane proteins localized on the ER and known to regulate ER structure and functions. Several studies have suggested that RTNs are involved in different important cellular functions such as changes in calcium homeostasis, ER-stress-mediated cell death, and autophagy. RTNs have been demonstrated to exert a cancer specific proapoptotic function via the interaction or the modulation of specific proteins. Reticulons have also been implicated in different signaling pathways which are at the basis of the pathogenesis of several neurodegenerative diseases. In this paper we discuss the accumulating evidence identifying RTN-1C protein as a promising target in the treatment of different pathologies such as cancer or neurodegenerative disorders.http://dx.doi.org/10.1155/2012/651805 |
| spellingShingle | Federica Di Sano Mauro Piacentini Reticulon Protein-1C: A New Hope in the Treatment of Different Neuronal Diseases International Journal of Cell Biology |
| title | Reticulon Protein-1C: A New Hope in the Treatment of Different Neuronal Diseases |
| title_full | Reticulon Protein-1C: A New Hope in the Treatment of Different Neuronal Diseases |
| title_fullStr | Reticulon Protein-1C: A New Hope in the Treatment of Different Neuronal Diseases |
| title_full_unstemmed | Reticulon Protein-1C: A New Hope in the Treatment of Different Neuronal Diseases |
| title_short | Reticulon Protein-1C: A New Hope in the Treatment of Different Neuronal Diseases |
| title_sort | reticulon protein 1c a new hope in the treatment of different neuronal diseases |
| url | http://dx.doi.org/10.1155/2012/651805 |
| work_keys_str_mv | AT federicadisano reticulonprotein1canewhopeinthetreatmentofdifferentneuronaldiseases AT mauropiacentini reticulonprotein1canewhopeinthetreatmentofdifferentneuronaldiseases |