The inhibition of ORMDL3 prevents Alzheimer's disease through ferroptosis by PERK/ATF4/HSPA5 pathway

The inhibition of ORMDL3 prevents Alzheimer's disease through ferroptosis by PERK/ATF4/HSPA5 pathway

Abstract Alzheimer's disease (AD) is a neurodegenerative disease with high incidence and widespread attention. There is currently no clear clarification of the pathogenesis. However, ORMDL3 causes ferroptosis in AD, and the potential mechanisms remain unclear. So, this study explore the functio...

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Bibliographic Details
Main Authors: Yankun Shao, Yilin Xu, Huang Di, Xinxiu Shi, Yingying Wang, Hongyu Liu, Lina Song
Format: Article
Language:English
Published: Wiley 2023-05-01
Series:IET Nanobiotechnology
Subjects:
Alzheimer's disease
ferroptosis
ORMDL3
PERK
Online Access:https://doi.org/10.1049/nbt2.12113
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