Evaluating Blood–Brain Barrier Permeability, Cytotoxicity, and Activity of Potential Acetylcholinesterase Inhibitors: In Vitro and In Silico Study

Evaluating Blood–Brain Barrier Permeability, Cytotoxicity, and Activity of Potential Acetylcholinesterase Inhibitors: In Vitro and In Silico Study

ABSTRACT Acetylcholinesterase inhibitors (AChEIs) remain the first‐line treatment for Alzheimer's disease. However, these drugs are largely symptomatic and often associated with adverse effects. This study aimed to evaluate novel pharmacophores for their in vitro AChEI activity, blood–brain bar...

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Bibliographic Details
Main Authors: L. M. Maboko, A. Theron, J.‐L. Panayides, W. Cordier, D. Fisher, V. Steenkamp
Format: Article
Language:English
Published: Wiley 2024-12-01
Series:Pharmacology Research & Perspectives
Subjects:
acetylcholinesterase inhibition
blood–brain barrier
cytotoxicity
synthetic compounds
Online Access:https://doi.org/10.1002/prp2.70043
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