Strategies for Treating Alzheimer’s: Current Approaches and Future Perspectives
Introduction and Purpose: Alzheimer’s disease is the most common cause of dementia, affecting millions of people worldwide and posing a significant challenge to modern medicine. This review explores the available treatment options, their limitations, and the future directions of research that ma...
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| Format: | Article |
| Language: | English |
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Nicolaus Copernicus University in Toruń
2025-05-01
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| Series: | Quality in Sport |
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| Online Access: | https://apcz.umk.pl/QS/article/view/58829 |
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| author | Adriana Skuba Katarzyna Załuska Agnieszka Świdniak Marta Biskup Aleksandra Bartoszek Karolina Kopeć Agnieszka Marut Jagoda Misiuk Julia Adamiuk Sylwia Nykiel |
| author_facet | Adriana Skuba Katarzyna Załuska Agnieszka Świdniak Marta Biskup Aleksandra Bartoszek Karolina Kopeć Agnieszka Marut Jagoda Misiuk Julia Adamiuk Sylwia Nykiel |
| author_sort | Adriana Skuba |
| collection | DOAJ |
| description |
Introduction and Purpose:
Alzheimer’s disease is the most common cause of dementia, affecting millions of people worldwide and posing a significant challenge to modern medicine. This review explores the available treatment options, their limitations, and the future directions of research that may bring breakthroughs in combating this devastating condition.
Materials and Methods:
This article is a comprehensive review based on a detailed analysis of peer-reviewed studies obtained from major scientific databases, such as PubMed. The selected articles focus on modern methods of treating Alzheimer’s disease, chosen for their relevance and importance to the subject.
Results:
This review highlights the complex pathogenesis of Alzheimer’s disease (AD), driven by amyloid-β accumulation, tau protein abnormalities, cholinergic deficits, and neuroinflammation. Current treatments, such as cholinesterase inhibitors and NMDA receptor antagonists, provide only temporary symptom relief, while emerging therapies, including immunotherapy and gene therapy, offer promising new directions. Advances in disease-modifying approaches targeting Aβ, tau, and genetic factors have shown potential, though challenges remain in achieving long-term efficacy and accessibility.
Conclusion:
Despite significant progress in understanding AD and developing new treatment strategies, an effective cure remains elusive. Immunotherapies and gene therapy represent promising avenues for disease modification, but further research is needed to optimize their effectiveness and accessibility. A multidisciplinary approach combining pharmacological, genetic, and lifestyle interventions is essential to improving patient outcomes and combating this devastating disease.
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| format | Article |
| id | doaj-art-c5fbc7759f034ea4a916ac5df0e5c889 |
| institution | Kabale University |
| issn | 2450-3118 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Nicolaus Copernicus University in Toruń |
| record_format | Article |
| series | Quality in Sport |
| spelling | doaj-art-c5fbc7759f034ea4a916ac5df0e5c8892025-08-20T03:49:21ZengNicolaus Copernicus University in ToruńQuality in Sport2450-31182025-05-014110.12775/QS.2025.41.58829Strategies for Treating Alzheimer’s: Current Approaches and Future PerspectivesAdriana Skuba0https://orcid.org/0009-0002-1474-8039Katarzyna Załuska1https://orcid.org/0009-0000-3189-5925Agnieszka Świdniak2https://orcid.org/0009-0005-4336-188XMarta Biskup3https://orcid.org/0009-0001-8760-2930Aleksandra Bartoszek4https://orcid.org/0009-0008-2071-3821Karolina Kopeć5https://orcid.org/0009-0001-1257-7865Agnieszka Marut6https://orcid.org/0009-0005-4884-7854Jagoda Misiuk7https://orcid.org/0009-0002-6227-7155Julia Adamiuk8https://orcid.org/0009-0003-5857-7646Sylwia Nykiel9https://orcid.org/0009-0007-6967-8927University of Rzeszów al. Tadeusza Rejtana 16C, 35-310 Rzeszów, PolandUniversity of Rzeszów al. Tadeusza Rejtana 16C, 35-310 Rzeszów, PolandUniversity of Rzeszów al. Tadeusza Rejtana 16C, 35-310 Rzeszów, PolandUniversity of Rzeszów Al. Tadeusza Rejtana 16C, 35-310 Rzeszów, PolandUniversity of Rzeszów Al. Tadeusza Rejtana 16C, 35-310 Rzeszów, PolandUniversity of Rzeszów al. Tadeusza Rejtana 16C, 35-310 Rzeszów, PolandUniversity of Rzeszów al. Tadeusza Rejtana 16C, 35-310 Rzeszów, PolandUniversity of Rzeszów al. Tadeusza Rejtana 16C, 35-310 Rzeszów, PolandUniversity of Rzeszów al. Tadeusza Rejtana 16C, 35-310 Rzeszów, PolandUniversity of Rzeszów al. Tadeusza Rejtana 16C, 35-310 Rzeszów, Poland Introduction and Purpose: Alzheimer’s disease is the most common cause of dementia, affecting millions of people worldwide and posing a significant challenge to modern medicine. This review explores the available treatment options, their limitations, and the future directions of research that may bring breakthroughs in combating this devastating condition. Materials and Methods: This article is a comprehensive review based on a detailed analysis of peer-reviewed studies obtained from major scientific databases, such as PubMed. The selected articles focus on modern methods of treating Alzheimer’s disease, chosen for their relevance and importance to the subject. Results: This review highlights the complex pathogenesis of Alzheimer’s disease (AD), driven by amyloid-β accumulation, tau protein abnormalities, cholinergic deficits, and neuroinflammation. Current treatments, such as cholinesterase inhibitors and NMDA receptor antagonists, provide only temporary symptom relief, while emerging therapies, including immunotherapy and gene therapy, offer promising new directions. Advances in disease-modifying approaches targeting Aβ, tau, and genetic factors have shown potential, though challenges remain in achieving long-term efficacy and accessibility. Conclusion: Despite significant progress in understanding AD and developing new treatment strategies, an effective cure remains elusive. Immunotherapies and gene therapy represent promising avenues for disease modification, but further research is needed to optimize their effectiveness and accessibility. A multidisciplinary approach combining pharmacological, genetic, and lifestyle interventions is essential to improving patient outcomes and combating this devastating disease. https://apcz.umk.pl/QS/article/view/58829Alzheimer's diseaseamyloidtauinflammationdementiaacetylcho |
| spellingShingle | Adriana Skuba Katarzyna Załuska Agnieszka Świdniak Marta Biskup Aleksandra Bartoszek Karolina Kopeć Agnieszka Marut Jagoda Misiuk Julia Adamiuk Sylwia Nykiel Strategies for Treating Alzheimer’s: Current Approaches and Future Perspectives Quality in Sport Alzheimer's disease amyloid tau inflammation dementia acetylcho |
| title | Strategies for Treating Alzheimer’s: Current Approaches and Future Perspectives |
| title_full | Strategies for Treating Alzheimer’s: Current Approaches and Future Perspectives |
| title_fullStr | Strategies for Treating Alzheimer’s: Current Approaches and Future Perspectives |
| title_full_unstemmed | Strategies for Treating Alzheimer’s: Current Approaches and Future Perspectives |
| title_short | Strategies for Treating Alzheimer’s: Current Approaches and Future Perspectives |
| title_sort | strategies for treating alzheimer s current approaches and future perspectives |
| topic | Alzheimer's disease amyloid tau inflammation dementia acetylcho |
| url | https://apcz.umk.pl/QS/article/view/58829 |
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